何延红

西南大学化学化工学院特聘教授

何延红，女，毕业于瑞典隆德大学，有机化学博士，西南大学化学化工学院特聘教授。

人物经历

1984.09 - 1988.06 本科，云南大学化学系

1988.07 - 1996.08 实习研究员、助理研究员，云南省热带作物科学研究所

1996.09 - 1999.06 硕士研究生，中山大学化学与化学工程学院

1999.06 - 2001.02 讲师, 中山大学化学与化学工程学院

2001.03 - 2004.11 博士研究生，瑞典隆德大学（Lund University）生物有机化学系

2005.12 - 特聘教授，西南大学化学化工学院

任课情况

曾承担或正在主讲的本科课程：《生物化学》(双语)、《有机化学》、《有机制备》

曾承担或正在主讲的研究生课程：《生物化学》

研究方向

生物有机化学、天然有机化学、有机合成化学

研究兴趣

酶催化的有机合成与生物转化；生物活性天然产物的全合成，天然产物类似物分子的设计、合成及构效关系研究；药物中间体合成；合成方法研究。

科研项目

1. 教育部留学回国人员科研启动基金（第30批），具有特殊生物活性的真菌代谢产物Conidiogenone 全合成研究，2006.09-2008.08.

2. 重庆市自然科学基金（CSTC 2006BB5377），具有特殊生物活性的新颖二萜类似物分子的设计与合成研究，2006.08-2008.07.

3. 教育部资助聘请外国文教专家重点项目，青霉菌的萜类分生孢子诱导因子， 2008年度

4. 西南大学高新技术培育基金（XSGX0601），青霉菌分生孢子诱导剂的合成研究，2006.12-2008.11，(与官智共同主持)

5. 西南大学博士基金（SWNUB2005012），真菌代谢产物Conidiogenone及其类似物的全合成与生物活性研究， 2006.01-2007.12.

申请专利5项

[1] 何延红，官智，李海虹，地衣芽孢杆菌碱性蛋白酶作为不对称直接Aldol反应催化剂的应用，2010，中国专利申请号：201010042093.6

[2] 何延红，官智，蔡光容，碳环化合物的合成方法，2009，中国专利申请号：200910103960.X

[3] 何延红，官智，汪钢强，多取代吡咯的绿色合成方法，2009，中国专利申请号：200910103956.3

[4] 何延红，官智，汪钢强，2,5-二甲基呋喃-3-甲酸乙酯的制备方法，2009，中国专利申请号：200910103289.9

[5] 何延红；官智；汪钢强多取代呋喃的绿色合成方法，2009，中国专利申请: 200910103962.9

学术论文

1. Yan-Hong He, Wen Hu, Zhi Guan, Enzyme-catalyzed direct three-component aza-Diels-Alder reation using hen egg white lysozyme, J. Org. Chem. 2012, 77(1), 200-207.

2. Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan, Zhi Guan, Chymopapain-catalyzed direct asymmetric aldol reaction, Adv. Synth. Catal. 2012, 354(4), 712-719

3. Bang-Hua Xie, Wei Li, Yan Liu, Hai-Hong Li, Zhi Guan, Yan-Hong He, The enzymatic asymmetric aldol reaction using acidic protease from Aspergillus usamii, Tetrahedron, 2012, 68(15), 3160-3164.

4. Wen Hu, Zhi Guan, Xiang Deng, Yan-Hong He, Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction, Biochimie 2012, 94(3), 656-661.

5. Bang-Hua Xie, Zhi Guan, Yan-Hong He, Biocatalytic Knoevenagel reaction using alkaline proteinase from Bacillus licheniformis, Biocatal. Biotransfor. 2012, 30(2), 238-244.

6. Chang-Heng Wang, Zhi Guan, Yan-Hong He, Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis, Green Chem. 2011, 13(8), 2048-2054.

7. Hai-Hong Li, Yan-Hong He, Yi Yuan, Zhi Guan, Nuclease p1: A new biocatalyst for direct asymmetric aldol reaction under solvent-free conditions, Green Chem. 2011, 13(1), 185-189.

8. Hai-Hong Li, Yan-Hong He, Zhi Guan, Protease-catalyzed direct aldol reaction, Catal. Commun. 2011, 12(7), 580-582.

9. Jian-Ping Fu, Yan-Hong He, Jun Zhong, Yang Yang, Xiang Deng, Zhi Gian, An efficient and general route to the synthesis of diethyl a,a-bromofluorophosphonates, J. Fluor. Chem. 2011, 132(9), 636-640.

10. Jian-Feng Cai, Zhi Guan, Yan-Hong He, The lipase-catalyzed asymmetric C-C Michael addition, J. Mol. Catal. B: Enzym. 2011, 68(3-4), 240-244.

11. Ke-Ling Xu, Zhi Guan, Yan-Hong He, Acidic proteinase from Aspergillus usamii catalyzed Michael addition of ketones tonitroolefins, J. Mol. Catal. B: Enzym. 2011, 71(3-4), 108-112.

12. Yan-Hong He, Gang-Qiang Wang, Ke-Ling Xu, Zhi Guan, An efficient procedure for the synthesis of polysubstituted pyrroles in an ionic liquid, Z. Naturforsch. 2011, 66b, 191-196.

13. Yan-Hong He, Ying Hu, Zhi Guan, Natural a-amino acid L-lysine catalyzed Knoevenagel condensations of a,b-unsaturated aldehydes and 1,3-dicarbonyl compounds, Synth. Commun. 2011, 41(11), 1617-1628.

14. Guang-Rong Cai, Zhi Guan, Yan-Hong He, Synthesis of six-membered functionalized carbocyclic compounds by one-pot reaction of hydroquinone derivatives and dienes, Synth. Commun. 2011, 41(20), 3016-3025.

15. Yang Yang, Yan-Hong He, Zhi Guan, Wei-Da Huang, A highly efficient large-scale asymmetric direct intermolecular aldol reaction employing L-prolinamide as a recoverable catalyst, Adv. Synth. Catal. 2010, 352(14-15), 2579-2587.

16. Ying Hu, Yan-Hong He, Zhi Guan, A simple method for the preparation of functionalized trisubstituted alkenes and a,b,g,d-unsaturated carbonyl compounds by using natural amino acid L-tryptophan, Catal. Commun. 2010, 11(7), 656-659.

17. Rong-Chang Tang, Zhi Guan, Yan-Hong He, Wen Zhu, Enzyme-catalyzed Henry (nitroaldol) reaction, J. Mol. Catal. B: Enzym. 2010, 63(1-2), 62-67.

18. Yan-Hong He, Gang-Qiang Wang, Zhi Guan, N-Substituted pyrrole synthesis by Paal-Knorr condensation using recyclable cationic exchange resin in water, J. Hetercyclic Chem. 2010, 47 (2), 486-489.

19. Gangqiang Wang, Zhi Guan, Rongchang Tang, Yanhong He, Ionic liquid as catalyst and reaction medium: A simple and efficient procedure for Paal-Knorr furan synthesis, Synth. Commun. 2010, 40(3), 370-377.

20. Ying Hu, Zhi Guan, Yan-Hong He, Nathan Louwagie, Meng-Jie Yao, L-Arginine used as a cost-effective and recyclable catalyst in ionic liquid for synthesis of a,b-unsaturated nitriles and ketones, J. Chem. Res. 2010, (1), 22-24.

21. Zhi Guan, Di Wu, Jian-Ping Fu, Yan-Hong He, A facile and efficient synthesis of diethyl aa-chlorofluoroalkanephosphonates, Heteroatom Chem. 2010, 21(4), 250-255.

22. Shuai Zhao, Yan-Hong He, Di Wu, Zhi Guan, A new general approach to 4-substituted-3-halo-2-quinolones, J. Fluor. Chem. 2010, 131(5), 597-605.

23. Gang-Qiang Wang, Zhi Guan, Rong-Chang Tang, Zeljko Ostojic, T. Nicholas Jones, Ting-Ting Wu, Yan-Hong He, A simple preparation of ethyl 2,5-dimethylfuran-3-carboxylate and 2,5-dimethylfuran-3,4-dicarboxylic acid from diethyl 2,3-diacetylsuccinate, J. Hetercyclic Chem. 2009, 46(3), 540-543.

24. Di Wu, Yanhong He, Rongchang Tang, Zhi Guan, The first synthesis of diethyl a,a-chlorofluorobenzylphosphonates, Synlett, 2009, (13), 2180-2182.

25. Yanhong He, Martin Johansson and Olov Sterner, Mild microwave-assisted hydrolysis of acetals under solvent-free conditions, Synthetic Communications, 2004, 34(22), 4153-4158.

26. Tomas Roncal, Shandra Cordobes, Unai Ugalde, Yanhong He and Olov Sterner, Novel diterpenes with potent conidiation inducing activity, Tetrahedron Letters, 2002, 43(38), 6799-6802.

参编书目

Yan-Hong He, Zhi Guan and Jian-Feng Cai,《Practical Methods for Biocatalysis and Biotransformations 2》Volume 2 edition, Editors: John Whittall and Peter W. Sutton, Publisher: Wiley-Blackwell, 2012 中编写了10.7 The lipase-catalyzed asymmetric Michael addition of thienyl nitroolefin to acetylacetone. ISBN-13: 978-1119991397.

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