刘剑锋

中国农业大学动物遗传育种繁殖系教授

刘剑锋，男，博士，中国农业大学动物科学技术学院教授、博士生导师，动物科学技术学院副院长。

人物经历

教育经历

2002.9–2005.6，中国农业大学，动物遗传育种与繁殖，博士；

1993.9–1996.6，中国农业大学（原北京农业大学），动物遗传育种与繁殖，硕士；

1989.9–1993.6，中国农业大学（原北京农业大学），动物遗传育种与繁殖，学士

工作经历

2008.11- 至今，中国农业大学，动物科技学院，副教授（中国农业大学“优秀引进人才”）、教授、副院长；

2005.8-2008.7，密苏里大学堪萨斯校区医学院，博士后、研究助理；

1996.6-2005.7，中国农业科学院，畜牧兽医研究所，副研究员

社会兼职

中国畜牧兽医学会动物遗传育种学分会、信息技术分会理事；

《Frontiers in Statistical Genetics and Methodology》、《PLoS ONE》期刊编委；

《Heredity》、《Bioinformatics》、《BMC Genomics》、《BMC Genetics》、《BMC Bioinformatics》、《Genetica》同行审稿人。

研究方向

主要致力于数量遗传学、生物信息学理论和计算技术研究；基于多组学信息进行畜禽复杂性状遗传机理解析；以猪和奶牛为研究对象进行常规育种和组学信息相结合的优化策略研究（基因组选择技术等）。

教学工作

《畜禽基因组学》（博士研究生学位课程，主讲）

《统计遗传学》（硕士研究生学位课程，参讲）

《动物育种原理和方法》（硕士研究生学位课程，参讲）

《畜牧生物统计与试验设计》（本科生必修课程，主讲）

学术成果

科研工作

2011.1-2015.12 科技部“863”优先主题项目“基于高密度SNP芯片的牛、猪基因组选择”（2011AA100302）子课题主持人；

2013.1-2016.12 主持国家自然科学基金“基于测定日模型建立中国荷斯塔奶牛基因组选择新方法”（31272419）；

2014.1-2016.12主持国家科技重大专项“奶牛产奶性能相关基因的克隆和功能验证”（2014ZX0800953B）；

2013.1-2017.12国家863计划“中国地方猪种生长、繁殖力等优异性状基因组学研究”（2013AA102503），参加；

2014.1-2016.12国家科技重大专项影响仔猪免疫力候选基因的克隆和功能验证（2014ZX0800945B），参加人。

发表论文

1. Fang M., Liu J., Sun D., Zhang Y., Zhang Q. & Zhang S. (2011) QTL mapping in outbred half-sib families using Bayesian model selection. Heredity 107, 265-76.

2. Fu W.X., Liu Y., Lu X., Niu X.Y., Ding X.D., Liu J.F. & Zhang Q. (2012) A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine. PLoS One 7, e32127.

3. Fu W.X., Wang C.L., Ding X.D., Zhang Z., Ma P.P., Weng Z.Q., Liu J.F. & Zhang Q. (2012) Genome-wide association analyses of the 15th QTL-MAS workshop data using mixed model based single locus regression analysis. BMC Proc 6 Suppl 2, S5.

4. Jiang J.C., Jiang L., Zhou B., Fu W.X., Liu J.F. & Zhang Q. (2011) Snat: a SNP annotation tool for bovine by integrating various sources of genomic information. Bmc Genetics 12.

5. Jiang J., Wang J., Wang H., Zhang Y., Kang H., Feng X., Yin Z., Bao W., Zhang Q. & Liu J.F. (2014) Global copy number analyses by next generation sequencing provide insight into pig genome variation. BMC Genomics 15, 593.

6. Jiang J., Zhang Q., Ma L., Li J., Wang Z. & Liu J.F. (2015) Joint prediction of multiple quantitative traits using a Bayesian multivariate antedependence model. Heredity 115, 29-36.

7. Jiang L., Jiang J., Yang J., Liu X., Wang J., Wang H., Ding X., Liu J. & Zhang Q. (2013) Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins. BMC Genomics 14, 131.

8. Jiang L., Liu J., Sun D., Ma P., Ding X., Yu Y. & Zhang Q. (2010) Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One 5, e13661.

9. Liu J., Liu Y., Liu X. & Deng H.W. (2007) Bayesian mapping of quantitative trait loci for multiple complex traits with the use of variance components. American Journal of Human Genetics 81, 304-20.

10.Liu J., Papasian C. & Deng H.W. (2007) Incorporating single-locus tests into haplotype cladistic analysis in case-control studies. Plos Genetics 3, e46.

11.Liu J., Pei Y., Papasian C.J. & Deng H.W. (2009) Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genetic Epidemiology 33, 217-27.

12.Liu J., Zhang Y., Zhang Q., Wang L. & Zhang J. (2006) Study on mapping quantitative trait loci for animal complex binary traits using Bayesian-Markov chain Monte Carlo approach. Sci China C Life Sci 49, 552-9.

13.Lu X., Fu W.X., Luo Y.R., Ding X.D., Zhou J.P., Liu Y., Liu J.F. & Zhang Q. (2012) Genome-wide association study for T lymphocyte subpopulations in swine. BMC Genomics 13, 488.

14.Lu X., Liu J., Fu W., Zhou J., Luo Y., Ding X., Liu Y. & Zhang Q. (2013) Genome-wide association study for cytokines and immunoglobulin G in swine. PLoS One 8, e74846.

15.Lu X., Liu J.F., Gong Y.F., Wang Z.P., Liu Y. & Zhang Q. (2011) Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine. Bmc Genetics 12, 79.

16.Ma Y., Wei J., Zhang Q., Chen L., Wang J., Liu J. & Ding X. (2015) A genome scan for selection signatures in pigs. PLoS One 10, e0116850.

17.Pan D., Zhang S., Jiang J., Jiang L., Zhang Q. & Liu J. (2013) Genome-wide detection of selective signature in Chinese Holstein. PLoS One 8, e60440.

18.Wang H., Jiang L., Liu X., Yang J., Wei J., Xu J., Zhang Q. & Liu J.F. (2013) A post-GWAS replication study confirming the PTK2 gene associated with milk production traits in Chinese Holstein. PLoS One 8, e83625.

19.Wang H., Jiang L., Wang W., Zhang S., Yin Z., Zhang Q. & Liu J.F. (2014) Associations between variants of the HAL gene and milk production traits in Chinese Holstein cows. Bmc Genetics 15, 125.

20.Wang H., Wang J., Sun S., Wang Y., Guo J., Ning C., Yang K. & Liu J.F. (2015) Identification of reference microRNAs for quantitative expression analysis in porcine peripheral blood mononuclear cells treated with polyinosinic-polycytidylic acid. International Journal of Immunogenetics 42, 217-25.

21.Wang J., Jiang J., Fu W., Jiang L., Ding X., Liu J.F. & Zhang Q. (2012) A genome-wide detection of copy number variations using SNP genotyping arrays in swine. BMC Genomics 13, 273.

22.Wang J., Jiang J., Wang H., Kang H., Zhang Q. & Liu J.F. (2014) Enhancing genome-wide copy number variation identification by high density array CGH using diverse resources of pig breeds. PLoS One 9, e87571.

23.Wang J., Jiang J., Wang H., Kang H., Zhang Q. & Liu J.F. (2015) Improved Detection and Characterization of Copy Number Variations Among Diverse Pig Breeds by Array CGH. G3 5, 1253-61.

24.Wang J., Wang H., Jiang J., Kang H., Feng X., Zhang Q. & Liu J.F. (2013) Identification of genome-wide copy number variations among diverse pig breeds using SNP genotyping arrays. PLoS One 8, e68683.

25.Wang J.Y., Luo Y.R., Fu W.X., Lu X., Zhou J.P., Ding X.D., Liu J.F. & Zhang Q. (2013) Genome-wide association studies for hematological traits in swine. Anim Genet 44, 34-43.

26.Zhou C., Liu Z., Liu Y., Fu W., Ding X., Liu J., Yu Y. & Zhang Q. (2013) Gene silencing of porcine MUC13 and ITGB5: candidate genes towards Escherichia coli F4ac adhesion. PLoS One 8, e70303.

发明专利

一种与中国荷斯坦奶牛产奶性状及体细胞数评分相关的SNP标记及其应用

软件著作（第一排名）：

贝叶斯A+基因组选择计算软件V1.0 (2014SRBJ0546)

多性状贝叶斯Cπ基因组选择计算软件V1.0 (2014SRBJ0006)

基于贝叶斯前相关模型的多性状基因组选择计算软件 (V1.02014SRBJ0480)

贝叶斯Lasso基因组选择计算软件V1.0 (2013SRBJ0778)

贝叶斯Cπ+基因组选择计算软件V1.0 (2013SRBJ0007)

多性状贝叶斯A基因组选择计算软件V1.0 (2013SRBJ0824)

贝叶斯B+基因组选择计算软件V1.0 (2013SRBJ0547)

肉牛杂交遗传评估系统V1.0 (2010SRBJ5812)

牛基因组单核苷酸多态性单机注释系统V1.0 (2011SRBJ2797)