刘成辉

陕西师范大学化学化工学院教授、博士生导师

刘成辉，男，博士，陕西师范大学化学化工学院教授、博士生导师。

个人经历

2009年7月于清华大学化学系获理学博士学位。现为陕师大化学化工学院教授，分析化学和化学生物学专业博士生导师。

现担任Wiley出版社ChemistrySelect期刊编委。

研究方向

研究方向：生化分析及分子诊断。

主要研究兴趣为：（1）生化分析与分子诊断；（2）功能材料表界面传感；（3）单分子与单颗粒分析。

学术成果

2016年获得国家基金委“优秀青年科学基金”资助；先后主持国家自然科学基金等省部级以上项目9项。作为通讯作者或第一作者在Angew. Chem. Int. Ed.,Chem. Sci.,Anal. Chem.,Chem. Commun.等发表论文50余篇。

30.Gaoting Wang, Weimin Tian, Xiaoling Liu*, Wei Ren, Chenghui Liu*. A new CRISPR-derived microRNA sensing mechanism based on Cas12a self-powered and rolling circle transcription (RCT)-unleashed real-time crRNA recruiting.Anal. Chem.,2020, DOI: 10.1021/acs.analchem.0c00680.

29.Hui Tian, Wenhan Zhao, Xiaolong Liu, Chenghui Liu*, Niancai Peng*. An integrated single microbead-arrayed μ-fluidic platform for the automated detection of multiplexed biomarkers.ACS Sens.,2020, 5, 798-806.

28.Zhenhao Zhang, Dandan Yang, Weimin Tian, Yan Qi, Wei Ren, Zhengping Li, Chenghui Liu*. Facile Clamp-Assisted Ligation Strategy for Direct Discrimination and Background-Free Quantification of Site-Specific 5‑Formylcytosine.Anal. Chem.,2020, 92, 3477-3482.

27.Wenjiao Fan, Wei Ren*, Liping Zhu, Chenghui Liu*.On-bead enzyme-catalyzed signal amplification for the high-sensitive detection of disease biomarkers.Methods in Enzymology,2020, 630, 179-197. (Invited Book Chapter)

26.Fu Chang, Yueying Sun, Dandan Yang, Wenjuan Yang, Yuanyuan Sun, Chenghui Liu*, Zhengping Li*. Specific Detection of RNA Mutation at Single-Base Resolution by Coupling Isothermal Exponential Amplification Reaction (EXPAR) with Chimeric DNA Probe-Aided Precise RNA Disconnection at the Mutation Site.Chem. Commun.,2019, 55, 6934-6937.

25.Weimin Tian, Pengjie Li, Wenli He, Chenghui Liu*, Zhengping Li*. Rolling Circle Extension-Actuated Loop-Mediated Isothermal Amplification (RCA-LAMP) for Ultrasensitive Detection of MicroRNAs.Biosens. Bioelectron.,2019, 128, 17-22.

24.Ya Li, Dailu Jia, Wei Ren*, Feng Shi, Chenghui Liu*. A Versatile Photoinduced Electron Transfer-Based Upconversion Fluorescent Biosensing Platform for the Detection of Disease Biomarkers and Nerve Agent.Adv. Funct. Mater.,2019, 29, 1903191.

23.Xiaohui Lu, Wenjiao Fan, Qinya Feng, Yan Qi, Chenghui Liu*, Zhengping Li. A Versatile Dynamic Light Scattering Strategy for the Sensitive Detection of Plant MicroRNAs Based-on Click Chemistry-Amplified Aggregation of Gold Nanoparticles.Chem. Eur. J.,2019, 25, 1701-1705.(Very Important Paper)

22.Yan Qi, Xiaohui Lu, Qinya Feng, Wenjiao Fan, Chenghui Liu*, Zhengping Li*. An Enzyme-Free MicroRNA Assay Based-on Fluorescence Counting of Click Chemical Ligation-Illuminated Magnetic Nanoparticles with Total Internal Reflection Fluorescence Microscopy.ACS Sens.,2018, 3, 2667-2674.

21.Yuanyuan Sun, Hui Tian, Chenghui Liu*, Dandan Yang, Zhengping Li*. A Clamp-Based One-Step Droplet Digital Reverse Transcription PCR (ddRT-PCR) for Precise Quantitation of Messenger RNA Mutation in Single Cells.ACS Sens.,2018, 3, 1795-1801.

20.Liping Zhu, Desheng Chen, Xiaohui Lu, Yan Qi, Pan He, Chenghui Liu,* Zhengping Li. An Ultrasensitive Flow Cytometric Immunoassay Based on Bead Surface-Initiated Template-Free DNA Extension.Chem. Sci.,2018, 9, 6605-6613.(Inside Front Cover, Hot Article of Chem Sci)

19.Wenjiao Fan, Yan Qi, Liying Qiu, Pan He, Chenghui Liu,* Zhengping Li. Click Chemical Ligation-Initiated On-Bead DNA Polymerization for the Sensitive Flow Cytometric Detection of 3´-Terminal 2´-O-Methylated Plant MicroRNA.Anal. Chem.,2018, 90, 5390-5397.

18.Yueying Sun, Yuanyuan Sun, Weimin Tian, Chenghui Liu,* Kejian Gao, Zhengping Li.*A novel restriction endonuclease GlaI for rapid and highly sensitive detection of DNA methylation coupled with isothermal exponential amplification reaction.Chem. Sci.,2018, 9, 1344-1351.

17.Desheng Chen, Xiaobo Zhang, Liping Zhu, Chenghui Liu,* Zhengping Li.* Single Microbead-Anchored Fluorescent Immunoassay (SMFIA): A Facile and Versatile Platform Allowing Simultaneous Detection of Multiple Antigens.Chem. Asian J.,2017, 12, 2894-2898.(Featured as Front Cover)

16.Yuanyuan Sun, Hui Tian, Chenghui Liu,* Yueying Sun, Zhengping Li.* One-step detection of microRNA with high sensitivity and specificity via target-triggered loop-mediated isothermal amplification (TT-LAMP).Chem. Commun.,2017, 53, 11040-11043.

15.Liying Qiu, Yuecheng Zhang, Chenghui Liu,* Zhengping Li.* A Versatile Size-Coded Flow Cytometric Bead Assay for Simultaneous Detection of Multiple MicroRNAs Coupled with a Two-Step Cascading Signal Amplification.Chem. Commun.,2017, 53, 2926-2929.

14.Xiangdong Wang, Hui Wang, Chenghui Liu,* Honghong Wang, Zhengping Li.* A three-way junction structure-based isothermal exponential amplification strategy for sensitive detection of 3’-terminal 2’-O-methylated plant microRNA.Chem. Commun.,2017, 53, 1124-1127.

13.Hui Tian, Yuanyuan Sun, Chenghui Liu,* Xinrui Duan, Wei Tang, Zhengping Li.* Precise Quantitation of MicroRNA in a Single Cell with Droplet Digital PCR Based on Ligation Reaction.Anal. Chem.,2016, 88, 11384−11389.

12.Junting Li, Qi Zhao, Feng Shi, Chenghui Liu,* Yanli Tang.* NIR-Mediated Nanohybrids of Upconversion Nanophosphors and Fluorescent Conjugated Polymers for High-Efficiency Antibacterial Performance Based on Fluorescence Resonance Energy Transfer.Adv. Healthcare Mater.,2016, 5, 2967-2971.(Highlighted by MaterialsViewsChina)

11.Chao Jiang, Ya Li, Chenghui Liu,* Liying Qiu, Zhengping Li. A General and Versatile Fluorescence Turn-On Assay for Detecting the Activity of Protein Tyrosine Kinases Based on Phosphorylation-Inhibited Tyrosyl Oxidation.Chem. Commun.,2016, 52, 12570-12573.(Featured as Front Cover)

10.Honghong Wang, Hui Wang, Chenghui Liu,* Xinrui Duan, Zhengping Li.* Ultrasensitive Detection of Telomerase Activity in a Single Cell Using Stem-loop Primer-mediated Exponential Amplification (SPEA) with Near Zero Nonspecific Signal.Chem. Sci.,2016, 7, 4945-4950.

9.Xiaohui Lu, Peipei Wang, Yucong Wang,* Chenghui Liu,* Zhengping Li. A Versatile Dual-Emission Fluorescent Microhybrid Enabling Visual Detection of Glucose and Other Oxidases-Based Biocatalytic Systems.Adv. Mater. Technol.,2016, 1, 1600024.(Inside Front Cover, Highlighted by MaterialsViewsChina)

8.XiaoboZhang, Chenghui Liu,* Honghong Wang, Hui Wang, Zhengping Li.* Rare Earth Ion Mediated Fluorescence Accumulation on a Single Microbead: An Ultrasensitive Strategy for the Detection of Protein Kinase Activity at the Single-Cell Level.Angew. Chem. Int. Ed.,2015, 54, 15186-15190.

7.Xiaobo Zhang, Chenghui Liu,* Lingbo Sun, Xinrui Duan, Zhengping Li.* Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level.Chem. Sci.,2015, 6, 6213-6218.(Highlighted by ChemistryWorld and Chemical Science Blog, Hot Article)

6.Haoxian Zhou, Hui Wang, Chenghui Liu,* Honghong Wang, Xinrui Duan, Zhengping Li.* Ultrasensitive genotyping with target-specifically generated circular DNA templates and RNA FRET probes.Chem. Commun.,2015, 51, 11556-11559.(Featured as Front Cover, Hot Article of ChemComm)

5.Yuecheng Zhang, Chenghui Liu,* Sujuan Sun, Yanli Tang, Zhengping Li.* Phosphorylation-Induced Hybridization Chain Reaction on Beads: An Ultrasensitive Flow Cytometric Assay for the Detection of T4 Polynucleotide Kinase Activity.Chem. Commun.,2015, 51, 5832-5835.(Featured as Inside Front Cover)

4.Chenghui Liu,* Fangfang Wang, Yucong Wang, Zhengping Li.* A versatile fluorescence turn-on assay for highly sensitive detection of tyrosine phosphatase activity.Chem. Commun.,2014, 50, 13983-13986.

3.Pengpo Zhang, Jiangyan Zhang, Chengli Wang, Chenghui Liu,* Hui Wang, Zhengping Li.* Highly sensitive and specific multiplexed microRNA quantification using size-coded ligation chain reaction (LCR).Anal. Chem.,2014, 86, 1076-1082.

2.Chenghui Liu,* Lijuan Chang, Honghong Wang, Jie Bai, Wei Ren, Zhengping Li. Upconversion Nanophosphor: An Efficient Phosphopeptides-Recognizing Matrix and Luminescence Resonance Energy Transfer Donor for Robust Detection of Protein Kinase Activity.Anal. Chem.,2014, 86, 6095-6102.

1.Fangfang Wang, Chenghui Liu,* Yunlong Fan, Yucong Wang, Zhengping Li.* Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform.Chem. Commun.,2014, 50, 8161-8163.

荣誉奖励

2015年度“陕西省青年科技新星”。

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