吴家睿

国科大杭州高等研究院生命与健康科学学院执行院长，中科院分子细胞科学卓越创新中心研究员

吴家睿，男，汉族，1956年12月生，九三学社社员，博士生导师。

人物经历

教育背景

1978-09，广州中山大学生物系本科

1982-09，中科院遗传研究所硕士

1989-07，瑞士苏黎世联邦理工学院博士

工作经历

1994-10，纽约州立大学卫生科学中心博士后

1997-10，中科院上海生化所研究员

2002-01，中科院上海生科院副院长

2005-01，中科大系统生物学系主任

2007-01，系统生物学重点实验室主任

2012-10~2019-02，上海科技大学生命科学与技术学院执行院长

2012-10，中科院上海高等研究院副院长

学术任职

2011，Journal of Molecular Cell Biology主编

2010，Frontiers in Systems Physiology副主编

2010，BMC Systems Biology副主编

2008，Communicative and Integrative Biology编委

2008，Journal of Biological Chemistry编委，编委

2008，Federation of Asian and Oceanian Biochemists and Molecular Biology (FAOBMB)中国区代表

2006，International Union of Biochemistry and Molecular Biology（IUBMB）中国区代表

2005，Cell Research编委，编委

2002，Chinese Science Bulletin执行副主编

社会兼职

2016-11，上海市政府参事

2023-12，上海市科普作家协会理事长

研究方向

细胞活动的蛋白质调控网络；复杂疾病的系统生物学研究

科研活动

科研项目

（1）２型糖尿病树鼩模型的创建，参与，院级级，2011-01--2013-12

（2）基于BMP信号转导网络的脂肪细胞生长与分化机制及其在代谢生理活动与病理过程中的功能研究，参与，国家级，2011-01--2015-08

（3）细胞生长过程细胞骨架可塑性的调控机制，参与，国家级，2010-01--2014-08

（4）基于纳米技术的2型糖尿病多重分子标记物的早期检测，参与，院级级，2009-06--2013-06

参与会议

（1）复杂性疾病与健康医学，2010-11，吴家睿

（2） Dynamic analysis of type 2 diabetic progression with proteomic approach，The 6th Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group，2010-08，Jiarui Wu

主要成就

在国外留学期间，主要从事细胞周期与DNA复制起始调控机理的研究工作，发现了哺乳动物细胞一个新的细胞周期调控点，首次把周期调控与DNA复制的起始控制机制细胞联系了起来。

多次参与国家和地方的科学规划工作：2004年任国家中长期科学和技术发展规划战略研究的“基础科学问题研究专题组”专家并担任学术秘书；2004年到2005年任“上海中长期科学和技术发展规划基础科学战略研究组”副组长；2009年任中国科学院“中国至2050年人口健康科技发展路线图战略研究组”副组长；2010年任中国科学院“十二五”人口健康领域规划编写组组长，以及上海市“十二五”基础科学规划研究组副组长。国家自然科学基金委员会生命科学部第三届和第四届专家咨询委员会委员；科技部“蛋白质研究”重大科学研究计划专家组副组长、召集人。

目前已经在国际学术刊物发表了100多篇研究论文。

所获荣誉

1998年度国家杰出青年基金获得者，1998年度中科院百人计划入选者，2004年被评为市统一战线为三个文明建设服务先进个人，2009年度上海市领军人才入选者。

代表论文

1. Song, Wei*; Wang, Jiguang; Yang, Ying; Jing, Naihe; Zhang, Xiangsun; Chen, Luonan#; Wu, Jiarui#.Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.JOURNAL OF MOLECULAR CELL BIOLOGY. 2012. 4(4):197-26.

2. Su, Zhi-Duan*; Sun, Liang; Yu, Dan-Xia; Li, Rong-Xia; Li, Huai-Xing; Yu, Zhi-Jie; Sheng, Quan-Hu; Lin, Xu; Zeng, Rong#; Wu, Jia-Rui#.Quantitative detection of single amino acid polymorphisms by targeted proteomics.JOURNAL OF MOLECULAR CELL BIOLOGY. 2011. 3(5):39-315.

3. Guo, Wei*; Zhang, Kun-Ming; Tu, Kang; Li, Yi-Xue; Zhu, Li; Xiao, Hua-Sheng; Yang, Ying; Wu, Jia-Rui#.Adipogenesis licensing and execution are disparately linked to cell proliferation.CELL RESEARCH. 2009. 19(2):216-223.

4. Xiong, Lei*; Kou, Fei; Yang, Ying; Wu, Jiarui#.A novel role for 1GF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop.JOURNAL OF CELL BIOLOGY. 2007. 178(6):995-17.

5. Wang, Zhenguo*; Wang, Lu; Zhang, Zhuzhen; Feng, Li; Song, Xue; Wu, Jiarui#.Apolipoprotein A-IV involves in glucose and lipid metabolism of rat.NUTRITION & METABOLISM. 02 Jul 2019. 16.

6. Liu, Xiaojing*; Han, Shuai; Yang, Ying; Kang, Jiuhong; Wu, Jiarui#.Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 28 Aug 2015. 464(3):730-736.

7. Zi, Zhenzhen#*; Zhang, Zhuzhen; Li, Qingrun; An, Weiwei; Zeng, Liyong; Gao, Dayuan; Yang, Ying; Zhu, Xueliang; Zeng, Rong; Shum, Winnie Waichi; Wu, Jiarui.CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.PLOS GENETICS. Aug 2015. 11(8).

8. An, Weiwei*; Zhang, Zhuzhen; Zeng, Liyong; Yang, Ying; Zhu, Xueliang; Wu, Jiarui#.Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.PLOS ONE. 10 Jul 2015. 10(7).

9. Li, Qing-Run*; Wang, Zi-Ming; Albrechtsen, Nicolai J. Wewer; Wang, Dan-Dan; Su, Zhi-Duan; Gao, Xian-Fu; Wu, Qing-Qing; Zhang, Hui-Ping; Zhu, Li; Li, Rong-Xia; Jacobsen, SivHesse; Jorgensen, Nils Bruun; Dirksen, Carsten; Bojsen-Moller, Kirstine N.; Petersen, Jacob S.; Madsbad, Sten; Clausen, Trine R.; Diderichsen, Borge; Chen, Luo-Nan#; Holst, Jens J.#; Zeng, Rong#; Wu, Jia-Rui#.Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery.EBIOMEDICINE. Feb 2018. 28:234-240.

10. Guo, Wei*; Chen, Jiangnan; Yang, Ying; Zhu, Jianbei; Wu, Jiarui#.Epigenetic programming of Dnmt3a mediated by AP2 alpha is required for granting preadipocyte the ability to differentiate.CELL DEATH & DISEASE. Dec 2016. 7.

11. Liu, Xiaojing*; Wang, Zhenguo; Yang, Ying; Li, Qingrun; Zeng, Rong; Kang, Jiuhong; Wu, Jiarui#.Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84.PROTEIN & CELL. Sep 2016. 7(9):692-696.

12. Tang, Jia-shu*; Li, Qing-run; Li, Jia-ming; Wu, Jia-rui#; Zeng, Rong#.Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics.SCIENTIFIC REPORTS. 21 Apr 2017. 7.

13. Li, Jiaming*; Li, Qingrun; Tang, Jiashu; Xia, Fangying; Wu, Jiarui#; Zeng, Rong.Quantitative Phosphoproteomics Revealed Glucose-Stimulated Responses of Islet Associated with Insulin Secretion.JOURNAL OF PROTEOME RESEARCH. Nov 2015. 14(11):4635-4646.

14. Sun, Liang*; Liang, Liming; Gao, Xianfu; Zhang, Huiping; Yao, Pang; Hu, Yao; Ma, Yiwei; Wang, Feijie; Jin, Qianlu; Li, Huaixing; Li, Rongxia; Liu, Yong; Hu, Frank B.; Zeng, Rong#; Lin, Xu#; Wu, Jiarui#.Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study.DIABETES CARE. Sep 2016. 39(9):1563-1570.

15. Hu, Rongkuan*; Yan, Huan; Fei, Xiaoyan; Liu, Haiyang#; Wu, Jiarui#.Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase.SCIENTIFIC REPORTS. 10 Apr 2017. 7.

16. Wu, Li*; Luo, Siwei; Ma, Siya; Liang, Zhi#; Wu, Jia-Rui#.Construction of light-sensing two-component systems in Escherichia coli.SCIENCE BULLETIN. 2017. 62(12):813-815.

17. Li, Meiyi*; Li, Chen; Liu, Wei-Xin; Liu, Conghui; Cui, Jingru; Li, Qingrun; Ni, Hong; Yang, Yingcheng; Wu, Chaochao; Chen, Chunlei; Zhen, Xing; Zeng, Tao; Zhao, Mujun; Chen, Lei; Wu, Jiarui#; Zeng, Rong#; Chen, Luonan#.Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma.JOURNAL OF MOLECULAR CELL BIOLOGY. Dec 2017. 9(6):489-503.

18. Luo, Si-Wei*; Liang, Zhi#; Wu, Jia-Rui#.Simultaneously measuring multiple protein interactions and their correlations in a cell by Protein-interactome Footprinting.SCIENTIFIC REPORTS. 24 Mar 2017. 7.

19. Luo, Siwei*; Jiang, Yihua; Liang, Zhi#; Wu, Jiarui.Quantitative detection of in vivo physical protein - protein interactions based on DNA sequence recognition.JOURNAL OF MOLECULAR CELL BIOLOGY. Aug 2015. 7(4):383-386.

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