周严

武汉大学生命科学学院教授博士生导师

周严：武汉大学生命科学学院教授、博士生导师。学科专业：发育神经生物学、干细胞生物学研究方向：神经干细胞的命运决定。

学习经历：

2000－2002 中国协和医科大学医学博士

1997－2000 中国协和医科大学理学博士

1991－1997 同济医科大学医学学士

主要工作经历与任职情况：

2011至今：武汉大学生命科学学院教授、博士生导师

2007－2011：耶鲁大学副研究科学家 (Associate Research Scientist)

2002－2007：耶鲁大学博士后

主要研究领域及兴趣：

本实验室主要应用胚胎学、遗传学和细胞生物学手段研究哺乳动物神经系统发育过程中，神经干细胞如何进行命运选择，特别是神经干细胞如何应用非对称细胞分裂产生分化细胞并同时自我更新。主要研究领域包括：

（1）各种外源信号和内源命运决定因子如何共同影响神经干细胞的命运决定；

（2）非编码RNA如何调控神经干细胞非对称分裂；

（3）神经系统肿瘤发生发展过程中，肿瘤干细胞样细胞的生物学特性。

主持课题项目：

承担国家重点基础研究发展计划（973）项目子课题和国家自然科学基金面上项目

代表性论文:

1. Zhou, Y. (2012) Cortical development and asymmetric cell division. Frontiers in Biology. 7(4):297-306

2. Zhou, Y., Atkins, J., Rompani, S., Bancescu, D., Tang, H., Petersen, P., Zou, K., Stewart, S., Zhong, W. (2007) The mammalian Golgi regulates Numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell 129 (1): 163-78

3. Zhou, Y., Du, G., Hu, X., Yu, S., Liu, Y., Xu, Y., Huang, X., Liu, J., Yin, B., Fan, M., Peng, X., Qiang, B., Yuan, J. (2005) Nectin-like molecule 1 is a protein 4.1 N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochimica et Biophysica Acta-Biomembranes, 1669(2): 142-54

4. Tang, H., Rompani, S. B., Atkins, J. B., Zhou, Y., Osterwalder, T., and Zhong, W. (2005). Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular Cellular Biology 25: 2899-2909.

5. Yang, H., Zhou, Y., Hu, X., Xu, Y., Yin, B., Zhu, S., Fan, W., Fan, M., Qiang, B., Yuan, J., and Peng, X. (2005) Human nectin-like 1, a novel membrane protein interacting with protein 4.1 R. Progress in Natural Science, 15 (2) : 189-192.

6. Huang, X., Yang, H., Zhou, Y., Liu, J., Yin, B., Peng, X., Qiang, B., and Yuan, J. (2004). Overexpression of human reticulon 3 (hRTN3) in astrocytoma. Clinical Neuropathology, 23: 1-7.

7. Zhou, Y., Hu, S., Huang, X., Zhou, H., Tan, X., Peng, X., Qiang, B., Yuan, J. (2002) Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs. Progress in Natural Science, 12(6): 477-480

8. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., and Qiang, B. (2002). cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Brain Research 928:147-155.

9. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., and Qiang, B. (2001). ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine, 79, 399-405.

10. Liu, Y., Yu, S., Zhou, Y., Wang, J., Liu, S., Yuan, J., Qiang, B, Fan, M. (2001). cDNA isolation, chromosomal mapping and genomic analysis of human homeobox gene LHX4. Chinese Journal of Biochemistry and Molecular Biology, 17 (5): 552-556

11. Zhou, H., Huang, X., Zhou, Y., Li, G., Yin, B., Ma, Y., Peng, X., Yuan, J., Qiang, B. Cloning and prokaryotic expression of HGLP cDNA. (2001) Chinese Science Bulletin, 46 (13), 1089-1092

12. Du, G., Pan, M., Zhou, Y., Chen, J., Yao, H., Yuan, J., Qiang, B. (2000) Cloning of human and mouse GRY-RBP cDNA. Chinese Science Bulletin, 45 (4), 343-350

13. Chen, J., Luo, W., Zhou, Y., Tan, X., Li, G., Huang, X., Zhou, H., Li, W., Yuan, J., Qiang, B. (2000) Cloning and eukaryotic expression of Human HCL cDNA. Progress in Natural Science, 10 (11): 1001-1005

14. Du, G., Zhou, Y., Chen, J., Wang, J., Yin, B., Yuan, J., Qiang, B. (2000). Clonng and expression analysis of MBLL cDNA. Chinese Science Bulletin, 45(7): 620-625.

15. Du, G., Zhou, Y., Chen, J., Wang, J., Huang, X., Yuan, J., Qiang, B. (1999) Expression of human GRY-RBP and analysis of its RNA binding activities. Chinese Journal of Biochemistry and Molecular Biology, 15 (6): 866-870

16. Zhou, Y., Du, G., Wang, J., Chen, J., Yuan, J., Qiang, B. (1999) Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein. Chinese Science Bulletin, 44(12): 1114-1119.

17. Wang, J., Du, G., Zhou, Y., Yin, B., Yuan, J., Qiang, B. (1999) Cloning and identification of PHF2 cDNA and its alternatively spliced transcripts. Chinese Science Bulletin, 44(15), 1382-1387

18.《基因组学》主译：袁建刚周严强伯勤 (原著：Genomes by Brown, T.A., 2000) ISBN 7-03-010114-6/Q.1136, 507页

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