夏之宁

重庆大学化学化工学院教授

夏之宁，男，重庆大学化学化工学院教授、博士生导师，重庆大学校长助理，1995年毕业于丹麦哥本哈根大学，获博士学位。教育部“跨世纪优秀人才”，教育部“高等学校青年教师奖”，国务院政府特殊津贴获得者。中国色谱学会理事，重庆市分析化学学科学术带头人，重庆市色谱学会理事长，重庆市分析测试学会副理事长。《色谱》、《环境化学》等杂志编委。

研究方向

1、活性天然产物：创新方法筛选中药中的活性成分；改进及应用现代制备技术从中药中获得活性单体成分；活性成分的分子、细胞及动物水平评价。

2、药物分析化学：手性分离分析方法研究；药物亲和分析；功能化毛细管电泳分析方法的建立及应用。

3、微波化学与波谱：微波化学反应的机理、微波热与非热作用、微波在有机化学、分析化学、材料化学中的应用。

学术成果

[1]Q.F.Fu,F.Q.Yang,H.Chen,Z.N.Xia,Enhancementofenantioselectivityinchiralcapillaryelectrophoresisusinghydroxypropyl-beta-cyclodextrinaschiralselectorundermolecularcrowdingconditionsinducedbydextranordextrin.Electrophoresis,2014,35(20):2938-2945.

[2]F.Li,R.Liu,F.Q.Yang,W.Xiao,C.Chen,Z.N.Xia,DeterminationofthreecurcuminoidsinCurcumalongabymicroemulsionelectrokineticchromatographywithprotectiveeffectsontheanalytes,AnalyticalMethods,2014,6(8):2566-2571.

[3]Q.Gou,L.B.Favero,S.S.Bahamyirou,Z.N.Xia,W.Caminati,InteractionsbetweenCarboxylicAcidsandAldehydes:ARotationalStudyofHCOOH-CH2O.JournalofPhysicalChemistryA,2014,118(45):10738-10741.

[4]G.Feng,Q.Gou,L.Evangelisti,Z.N.Xia,W.Caminati,Conformationalequilibriaincarboxylicacidbimolecules:arotationalstudyofacrylicacid-formicacid.PhysicalChemistryChemicalPhysics,2013,15(8):2917-2922.

[5]F.Q.Yang,J.Yang,X.M.Zhang,P.Xu,Z.N.Xia,AnalysisofvolatilecomponentsinCurcumarhizomebymicroemulsionelectrokineticchromatography,JournalofChromatographicScience,2013,51(2):155-160.

[6]J.Du,Z.N.Xia,Measurementofthecatalyticactivityofgoldnanoparticlessynthesizedbyamicrowave-assistedheatingmethodthroughtime-dependentUVspectra,AnalyticalMethods,2013,5(8):1991-1995.

[7]F.Li,F.Q.Yang,Z.N.Xia,SimultaneousDeterminationofTenNucleosidesandRelatedCompoundsbyMEEKCwith[BMIM]PF6asOilPhase,Chromatographia,2013,76(15-16):1003-1011.

[8]Z.N.Xia,Y.X.Lin,L.X.Guo,F.Q.Yang,P.Xu,Y.L.Zhang,J.H.Liu,Developmentofacell-basedhigh-throughputperoxisomeproliferator-activatedreceptors(PPARs)screeningmodelanditsapplicationforevaluationoftheextractsfromRhizomaCoptis,JournalofAsianNaturalProductsResearch,2013,15(3):225-234.

[9]Z.H.Li,G.Chen,S.Qiao,R.H.Liang,C.Lan,Z.N.Xia,DesignandSynthesisofSomeNewN-PhenylanthranilicAcidsfromHighlyStericallyHinderedAnilines,SyntheticCommunications,2013,43(9):10.

[10]H.L.Zuo,F.Q.Yang,W.H.Huang,Z.N.Xia,Preparativegaschromatographyanditsapplications,JournalofChromatographicScience,2013,51(7):704-715.

[11]H.L.Zuo,S.J.Chen,D.L.Zhang,J.Zhao,F.Q.Yang,Z.N.Xia,QualityevaluationofnaturalCordycepssinensisfromdifferentcollectingplacesinChinabythecontentsofnucleosidesandheavymetals,AnalyticalMethods,2013,5(20):5450-5456.

[12]C.Chen,F.Q.Yang,H.L.Zuo,Y.L.Song,Z.N.Xia,W.Xiao,Applicationsofbiochromatographyinthescreeningofbioactivenaturalproducts,JournalofChromatographicScience,2013,51(8):780-790.

[13]L.X.Li,Z.N.Xia,F.Q.Yang,H.Chen,Y.L.Zhang,Enantioselectiveanalysisofofloxacinenantiomersbypartial-fillingcapillaryelectrophoresiswithbacteriaaschiralselectors,JournalofSeparationScience,2012,35(16):2101-2107.

[14]F.Q.Yang,R.Lv,Y.L.Zhang,andZ.N.Xia,Comparisonstudyonnucleosidesandnucleotidesinediblemushroomspeciesbycapillaryzoneelectrophoresis,AnalyticalMethods,2012,4(2):546-549.

[15]L.X.Guo,Z.N.Xia,X.Gao,F.Yin,J.H.Liu,Glucagon-likepeptide1receptorplaysacriticalroleingeniposide-regulatedinsulinsecretioninINS-1cells,ActaPharmacologicaSinica,2012,33(2):237-241.

[16]J.Du,Z.N.Xia,Interactionsofgoldnanoparticlesandlysozymebyfluorescencequenchingmethod,AnalyticalLetters,2012,45(15):2236-2245.

[17]P.Xu,Z.N.Xia,Y.X.Lin,ChemicalconstituentsfromEdgeworthiagardneri(Thymelaeaceae),BiochemicalSystematicsandEcology,2012,45:148-150.

[18]Z.T.Chen,Z.B.Zhong,Z.N.Xia,F.Q.Yang,X.J.Mu,SeparationofFluoroquinolonesbyMEKCModifiedwithHydrophobicIonicLiquidasaModifier,Chromatographia,2012,75(1-2):65-70.

[19]Z.H.Li,S.Y.Xiao,R.H.Liang,Z.N.Xia,Synthesisof2-(arylamino)nicotinicacidsinhigh-temperaturewater,ResearchonChemicalIntermediates,2012,38(7):1691-1697.

[20]H.L.Zuo,F.Q.Yang,X.M.Zhang,Z.N.Xia,Separationofcis-andtrans-AsaronefromAcorustatarinowiibyPreparativeGasChromatography,JournalofAnalyticalMethodsinChemistry,2012,2012:402081.

[21]X.J.Mu,N.N.Yu,C.S.Wang,X.B.Zou,Z.Abulimite,Z.N.Xia,EvaluationofanewsubstrateformeasurementofserumPONarylesteraseactivity,Talanta,2012,88:711-716.

[22]X.M.Jiang,Z.N.Xia,L.H.Deng,W.L.Wei,J.Chen,J.M.Xu,H.Y.Li,EvaluationofAccuracyfortheMeasurementofOctanol-WaterPartitionCoefficientbyMEEKC,Chromatographia,2012,75(7-8):347-352.

[23]Y.Wang,F.Li,F.Q.Yang,H.L.Zuo,Z.N.Xia,Simultaneousdeterminationofα-,β-andγ-asaroneinAcorustatarinowiibymicroemulsionelectrokineticchromatographywith[BMIM]PF6asoilphase,Talanta,2012,101:510-515.

[24]G.Feng,L.Evangelisti,L.B.Favero,J.U.Grabow,Z.N.Xia,W.Caminati,OntheweakO-H···halogenhydrogenbond:arotationalstudyofCH3CHClF···H2O.PhysicalChemistryChemicalPhysics,2011,13(31):14092-14096.

[25]F.Q.Yang,H.K.Wang,H.Chen,J.D.Chen,Z.N.Xia,Fractionationofvolatileconstituentsfromcurcumarhizomebypreparativegaschromatography,JournalofAutomatedMethods&ManagementinChemistry,2011,2011:942467.

[26]J.Yang,Z.N.Xia,F.Q.Yang,R.Lv,UseofRelativeMobilitytoEstimateOctanol-WaterPartitionCoefficientsofDrugsbyMicroemulsionElectrokineticChromatography,ActaChimicaSinica,2011,69(7):810-814.

[27]Z.H.Li,Z.N.Xia,G.Chen,Catalyst-freeaminationof2-chloronicotinicacidinwaterundermicrowaveirradiation,JournalofChemicalResearch,2011,(12):709-711.

[28]K.Y.Shi,Z.N.Xia,T.T.Gan,X.M.Jiang,C.Xia,Applicationsofreal-timemonitoringtechniquesinchemicalsyntheticingredients,SpectroscopyandSpectralAnalysis,2010,30(2):499-503.

[29]G.H.Chen,Z.N.Xia,Y.Lu,PredictionofCell-PenetratingPeptidesUsingbothSupportVectorMachineandLinearDiscriminantAnalysis,ActaChimicaSinica,2010,68(11):1137-1142.

[30]Z.N.Xia,J.Yang,L.X.Li,F.Q.Yang,X.M.Jiang,DeterminationofOctanol-WaterPartitionCoefficientsbyMEEKCBasedonPeak-ShiftAssay,Chromatographia,2010,72(5-6):495-501.

[31]G.H.Chen,Z.N.Xia,Y.Lu,Three-dimensionalvectorofpharmacophoreatomicinteractionanditsapplicationstostereoisomericdescription,ChemometricsandIntelligentLaboratorySystems,2010,102(2):91-99.

[32]Y.H.Zhang,Z.N.Xia,L.T.Qin,S.S.Liu,Predictionofblood-brainpartitioning:Amodelbasedonmolecularelectronegativitydistancevectordescriptors,JournalofMolecularGraphics&Modelling,2010,29(2):214-220

[33]Z.N.Xia,T.T.Gan,H.Chen,R.Lv,W.L.Wei,F.Q.Yang,Anewopentubularcapillarymicroextractionandsweepingfortheanalysisofsuperlowconcentrationofhydrophobiccompounds,JournalofSeparationScience,2010,33(20):3221-3230.

[34]J.H.Jing,G.Z.Liang,H.Mei,S.Y.Xiao,Z.N.Xia,Quantitativestructure-mobilityrelationshipstudiesofdipeptidesincapillaryzoneelectrophoresisusingthree-dimensionalholographicvectorofatomicinteractionfield,MolecularSimulation,2009,(5):263-269.

[35]Z.N.Xia,S.Long,S.Y.Xiao,X.B.Zou,A.D'Aurizio,M.Panunzio,Microwave-AssistedCarbonyl-CarbonylCouplingRouteforthePreparationofaUsefulIntermediateintheSynthesisofCarbapenems,SyntheticCommunications,2009,39(12):2151-2160.

[36]L.X.Guo,J.H.Liu,Z.N.Xia,GeniposideinhibitsCOCl2-inducedPC12cellsdeathviathemitochondrialpathway,ChineseMedicalJournal,2009,122(23):2886-2892.

[37]X.M.Jiang,Z.N.Xia,W.L.Wei,Q.Gou,DirectUVdetectionofunderivatizedaminoacidsusingcapillaryelectrophoresiswithonlinesweepingenrichment,JournalofSeparationScience,2009,32(11):1927-1933.

[38]Z.N.Xia,L.X.Li,J.Yang,C.Q.Xiong,Investigationofinteractionbetweenthedrugandcellmembranebycapillaryelectrophoresis,ScienceinChinaSeriesB-Chemistry,2009,52(12):2200-2204.

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