崔胜

中国农业大学生物学院教授

崔胜，1961年8月生，男，汉族，甘肃省会宁县人，博士，中国农业大学生物学院教授、博士生导师，国家杰出青年基金获得者，973首席科学家，动物学与动物生理学系主任。

人物经历

主要经历

1978年至1989年，先后在甘肃农业大学兽医学系攻读学士、硕士和博士学位，获动物解剖学、组织学与胚胎学专业博士学位。1990年至1993年，在甘肃农业大学兽医学系从事动物生理学以及生殖与发育生物学的教学和科学研究工作；1993年至1995年在英国爱丁堡MRC（Medical Research Council，Edinburgh）生殖生物学中心作博士后研究，主要从事动物胚胎期垂体促性腺激素分泌调控机制的研究；GnRH受体的DNA序列分析及核酸探针的合成等研究工作。1996年回国后，先后受国家自然科学基金项目、国家863青年基金的资助，主要从事动物胚胎期下丘脑-垂体-性腺轴调节机制的建立和相关机理的研究工作。另外，1999年至2000年在以色列Bar-Ilan大学发育神经生物学实验室进行合作研究，主要研究LIM同源盒基因对神经元增殖和分化过程的调控作用。2005年6月至2006年12月，在英国MRC人类生殖生物学中心以高级研究学者的身份从事垂体促性腺激素分泌调控机制的研究工作。

学术兼职

中国生殖生物学会理事兼副秘书长，动物生理生化学会副理事长，英国生殖生物学会会员，中国畜牧兽医学会动物生理生化分会副理事长

研究方向

动物胚胎期下丘脑-垂体-性腺轴的发生与建立；类固醇激素和同源异型基因族蛋白对神经元增殖、分化的调节；动物生殖与发育的神经内分泌调节机制。

主讲课程

《动物生理学》（本科）

《发育生物学专题》（研究生）

学术成果

发表论文

已在《Journal of Pineal Research》、《Endocrinology》、《Journal of Biological Chemistry》、《Journal of Endocrinology》、《Journal of Cellular Physiology》、《PLoS One》、《Journal of Neuroendocrinology》、《Steroids》、《Cell and Tissue Research》、《Histochemistry and Cell Biology》、《Brain Research》和《Developmental Brain Research》等国际学术杂志发表研究论文50余篇。

He J, Zhang J, Wang Y, Liu W, Gou K, Liu Z*, Cui S*. MiR-7 Mediates the Zearalenone Signaling Pathway Regulating FSH Synthesis and Secretion by Targeting FOS in Female Pigs. Endocrinology. 2018, 159(8):2993-3006. doi: 10.1210en.2018-00097.

Wei C, Lin H, Cui S*. The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Stem Cells Dev. 2018, 27(9):624-636. doi: 10.1089scd.2017.0233.

Zhang J, Qiu J, Zhou Y, Wang Y, Li H, Zhang T, Jiang Y, Gou K*, Cui S*, LIM homeobox transcription factor Isl1 is required for melatonin synthesis in the pig pineal gland. J Pineal Res, 2018, 65(1):e12481. doi: 10.1111

Li X, Wang S, Zhang L, Zhang L, Liu J, Luo H, Gou K, Cui S*. Amitriptyline plays important roles in modifying the ovarian morphology and improving its functions in rats with estradiol valerate-induced polycystic ovary. Arch Pharm Res. 2017 Sep 8. doi: 10.1007/s12272-015-0573-z. [Epub ahead of print]

He J, Wei C, Li Y, Liu Y, Wang Y, Pan J, Liu J, Wu Y*, Cui S*. Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30. Mol Cell Endocrinol. 2017 Aug 19. pii: S0303-7207(17)30432-X. doi: 10.1016j.mce.2017.08.010. [Epub ahead of print]

Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S*. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. J Endocrinol. 2017 Jul;234(1):1-14. doi: 10.1530JOE-16-0488.

Zhang L, Gao J, Cui S*. miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7. J Mol Endocrinol. 2017 May;58(4):199-210. doi: 10.1530/JME-16-0248.

Gai Y, Zhang J, Wei C, Cao W, Cui Y, Cui S*. miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla. Am J Physiol Cell Physiol. 2017 May 1;312(5):C663-C672. doi:10.1152ajpcell.00345.2016. Epub 2017 Mar 29.

Yu C, Li M, Wang Y, Liu Y, Yan C, Pan J, Liu J, Cui S*. MiR-375 Mediates CRH Signaling Pathway in Inhibiting E2 Synthesis in Porcine Ovary. Reproduction. 2016 Oct 18. pii: REP-16-0323

Wang S, Liu J, Li X, Ji X, Zhang J, Wang Y, Cui S*. MiR-125b Regulates Primordial Follicle Assembly by Targeting Activin Receptor Type 2a in Neonatal Mouse Ovary. Biol Reprod. 2016 Apr;94(4):83. doi: 10.1095/biolreprod.115.131128. Epub 2016 Mar 9.

Yan C, Yu C, Zhang D, Cui Y, Zhou J, Cui S*. Protein Inhibitor of Activated STAT Y (PIASy) Regulates Insulin Secretion by Interacting with LIM Homeodomain Transcription Factor Isl1. Sci Rep. 2016 Dec 21;6:39308. doi: 10.1038srep39308.

Liu Y, Li Y, Zhang D, Liu J, Gou K, Cui S*. Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum. Mol Endocrinol. 2015, 29(5):703-15.

Ma Q, Zhao J, Cao W, Liu J, Cui S*. Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver. Am J Physiol Gastrointest Liver Physiol. 2015, 308(4):G277-86.

Chen J, Fu R, Cui Y, Pan J, Li Y, Zhang X, Evans SM, Cui S, Liu J. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. Mol Endocrinol. 2014 Aug;28(8):1276-90. doi: 10.1210me.2013-1410.

Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans SM, Cui Y, Cui S*. LIM homeodomain transcription factor Isl1 directs normal pyloric development via targeting Gata3. BMC Biology. 2014, 12:25.

Cao W, Chen W, Liang X, Zhou J, Wei C, Cui S, Liu J. All-trans-retinoic Acid ameliorates the inflammation by inducing transforming growth factor Beta 1 and interleukin 10 in mouse epididymitis. Am J Reprod Immunol. 2014, 71(4):312-21.

Zhang X, Li J, Liu J, Luo H, Gou K, Cui S*. Prostaglandin F2α upregulates Slit/Robo expression in mouse corpus luteum during luteolysis. J Endocrinol. 2013, 218(3):299-310.

Chen J, Fu R, Cui Y, Li Y, Pan J, Liu J, Luo H, Yin J, Li D, Cui S*. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem. 2013, 288(17):12395-12405.

Zhang N, Lin J, Chen J, Liu X, Liu J, Luo H, Li Y, and Cui S*. MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein. J Biol Chem. 2013, 288(15):10361-10373.

Zhang J, Ji X, Zhou D, Li Y, Lin J, Luo H, Liu J and Cui S*. miR-143 is critical for the formation of primordial follicles in mice. Front Biosci (Landmark) 2013; 18(1): 588-597.

Liang X, Zhou D, Wei C, Luo H, Liu J, Fu R , Cui S*. MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS ONE. 2012, 7(3):e33861.

Sun D, Cui T, Luo H, Li R, Cui S, Liu J. Cell-specific distributions of estrogen receptor alpha (ERα) and androgen receptor (AR) in anterior pituitary glands from adult cockerels as revealed by immunohistochemistry. Cell Tissue Res. 2012;348(3):551-558.

Fu R, Liu J, Fan J, Li R, Yin J, Cui S*. Novel evidence that testosterone promotes cell proliferation and differentiation via G protein-coupled receptors in the rat L6 skeletal muscle myoblast cell line. J Cell Physiol 2012; 227(1):98-107.

Wu Y, Luo H, Liu J, Kang D, McNeilly AS, Cui S*. LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis. Endocrinology. 2010; 151(10): 4787-4800.

Zhang X, Zhang L, Huo S, Wang J, Cui S*. Neonatal superior ovarian nerve transection inhibits follicle development by enhancing follicular atresia and suppressing granulosa cell proliferation in rats. Reprod Fertil Dev. 2010; 22(7): 1148-1158.

Huo S, Xu Z, Zhang X, Zhang J, Cui S*. Testicular denervation in prepuberty rat inhibits seminiferous tubule development and spermatogenesis. J Reprod Dev. 2010; 56(4): 370-378.

Hu G, Xue J, Duan H, Yang Z, Gao L, Luo H, Mu X, Cui S*. IFN-γ induces IFN-α and IFN-β expressions in cultured rat intestinal mucosa microvascular endothelial cells. Immunopharmacol Immunotoxicol. 2010; 32(4): 656-662.

Chen D, Wang G, Luo H, Liu J, Cui S*. Isl-1 down-regulates DRG cell proliferation during chicken embryo development. Neuro Endocrinol Lett. 2010; 31(1): 67-72.

Wang G, Chen D, Luo H, Liu J, Ji X, Fan J, Cui S*. Low-dose ethanol suppresses 17beta-estradiol activity in GH4C1 pituitary tumor cells. Cell Biol Toxicol. 2010; 26(3): 265-277.

Fan JJ, Zhou JL, Li JH, Cui S*. Accessory sex glands of male mice have the ability to synthesize taurine via the cysteine sulfinate decarboxylase pathway. Cell Biol Int. 2009; 33(6): 684-689.

Wu YJ, Chen da W, Liu JL, Zhang JH, Luo HS, Cui S*. Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo. Steroids. 2009; 74(4-5): 441-448.

Zhang L and Cui S*. Effects of daidzein on testosterone synthesis and secretion in cultured mouse Leydig cells. Asian-Austral J Anim Sci. 2009; 22(5): 618-625.

Luo H, Liu J, Kang D, Cui S*. Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation. Histochem Cell Biol. 2008; 129(4): 525-533.

Liu S, Luo H, Liu J, McNeilly AS, Cui S*. Specificity protein 1 (Sp1) plays role in regulating LIM homeodomain transcription factor Lhx4 gene expression. Biochem Biophys Res Commun. 2008; 366(1): 36-41.

Yang JY, Wang GX, Liu JL, Fan JJ, Cui S*. Toxic effects of zearalenone and its derivatives alpha-zearalenol on male reproductive system in mice. Reprod Toxicol. 2007; 24(3-4): 381-387.

Yuan X, He Y, Liu J, Luo H, Zhang J, Cui S*. Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus. Histochem Cell Biol. 2007; 127(4): 423-432.

Yang J, Zhang Y, Wang Y, Cui S*. Toxic effects of zearalenone and alpha-zearalenol on the regulation of steroidogenesis and testosterone production in mouse Leydig cells. Toxicol In Vitro. 2007; 21(4): 558-565.

Zhang JH, Liu JL, Wu YJ, Cui S*. LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry. J Pineal Res. 2006; 41(3): 247-254.

Chen HP, Fan J, Cui S*. Detection and estrogen regulation of leptin receptor expression in rat dorsal root ganglion. Histochem Cell Biol. 2006; 126(3):363-369.

Li JH, Ling YQ, Fan JJ, Zhang XP, Cui S*. Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice. Histochem Cell Biol. 2006; 125(6): 607-613.

Liu J, Liu Z, Yi S, Cui S*. Islet-1 expression and its co-localization with luteinising hormone, thyroid stimulating hormone and oestrogen receptor alpha in the developing pituitary gland of sheep fetuses. J Neuroendocrinol, 2005; 17(12): 773-780.

Liu J, Chen D, Goldstein RS，Cui S*.Effects of male and female sex steroids on the development of normal and the transient Froriep's dorsal root ganglia of the chick embryo. Dev Brain Res. 2005; 155(1): 14-25.

Liu J, Cui S*. Ontogeny of estrogen receptor (ER) alpha and its co-localization with pituitary hormones in the pituitary gland of chick embryos. Cell Tissue Res. 2005; 320(2): 235-242.

Liu J, He Y, Wang X, Zheng X, Cui S*. Developmental changes of Isl1 and its co-localization with pituitary hormones in the pituitary gland of chick embryo by immunohistochemistry. Cell Tissue Res. 2005; 322(2): 279-287.

课题项目

国家自然科学基金面上项目 MicroRNA-7对垂体促性腺激素合成和分泌的调节功能及分子机理（31772692） 2018-2021

国家自然科学基金重点项目猪垂体促性腺激素合成和分泌的分子机理（3143000189） 2015-2019

国家重点基础研究项目猪繁殖力的生理学及相关遗传调控机理（2014CB138500）首席科学家兼课题五组长 2014-2018

国家自然科学基金面上项目 Isl-1对睾丸发育和精子发生的调节功能和分子机理（31372393） 2014-2017

国家自然科学基金面上项目 Isl-1对促性腺激素细胞的增殖分化和激素分泌的调节功能及分子机理（31172287） 2012-2015

国家重大基础研究项目遗传因素导致精子异常的调控机理（2009CB941702）子课题2009-2014

国家自然科学基金面上项目睾丸神经支配和促黄体激素（LH）对睾酮分泌的调控机制（30871846） 2009-2011

国家重大基础研究项目国家重大基础研究项目卵泡成熟的调控网络（2007CB947402） 2008-2013

国家自然科学基金重点项目垂体发育和促性腺激素分泌的细胞和分子机理（30630011） 2006-2011

专利情况

获得国家发明专利授权一项。