巢晖

中山大学教授

巢晖，男，1970年3月出生，籍贯湖南汨罗，理学博士，中山大学教授、博士生导师。

人物经历

教育经历

学士（1988-1992）：湘潭师范学院（现为湖南科技大学）化学系

硕士（1994-1997）：南开大学化学学院

博士（1997-2000）：中山大学化学与化学工程学院

访问学者 (2000-2003)：香港科技大学化学系

博士后（2004-2005）：美国Texas A&M大学化学系

工作经历

讲师（2000-2002）：中山大学化学与化学工程学院

副教授（2002-2007）：中山大学化学与化学工程学院

教授（2007-2016）：中山大学化学与化学工程学院

教授（2016-）：中山大学化学学院

2002年6月：被遴选为中山大学无机化学专业、化学生物学专业硕士生导师

2006年11月：被遴选为中山大学无机化学专业博士生导师

2008年10月：被批准为中山大学化学生物学专业博士生导师

2005年-：生物无机与合成化学教育部重点实验室固定研究人员

讲授课程

1. 本科生：《化学学习与研究》、《无机化学》、《无机化学实验》、《普通化学》、《现代化学》（逸仙班）、《化学生物学实验》、《今日化学》、《化学前沿》（基础学科拔尖学生培养实验班）

2. 研究生：《配位化学》、《化学前沿进展》

学术成果

科研项目

承担国家自然科学基金（包括国家杰出青年科学基金项目、重大研究计划培育项目、面上项目、青年项目）、973计划课题、教育部新世纪优秀人才支持计划项目、教育部创新团队项目（核心成员）、教育部科学技术研究重点项目、教育部高校博士点基金博导类课题、教育部留学回国人员科研启动基金、广东省自然科学基金团队项目（核心成员）、广东省自然科学基金自由项目、国家重点实验室开放基金和中山大学青年教师重点培育计划等20多项课题研究。

论著一览

Chem. Soc. Rev., 46 (2017) 5771-5804.(Inside front cover)

2. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”,Coord. Chem. Rev., 2018, DOI: 10.1016/j.ccr.2017.10.022.

3. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke,Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”,Coord. Chem. Rev., 363 (2018) 17–28.

4. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”,Coord. Chem. Rev., 310 (2016) 16-40.

5. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”,Coord. Chem. Rev., 281 (2014) 100-113.

6. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”,Curr. Opin. Chem. Biol., 43 (2018) 51-57.

7. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”,Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.

Angew. Chem. Int. Ed., 56 (2017) 14898-14902.(VIP Article,Inside front cover)

9. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”,Angew. Chem. Int. Ed., 54 (2015) 14049-14052.(VIP Article)

10. Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”,Chem. Sci., 9 (2018) 5183–5190.

11. Guanying Li, Yu Chen,Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”,Chem. Sci., 4 (2013) 4426-4433.

Biomaterials, 83 (2016) 321-331.

13. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang,Lei Jiang,Gilles Gasser,Liangnian Ji,Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”,Biomaterials, 63 (2015) 102-114.

14. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivativesin vivousing a two-photon phosphorescent probe”,Biomaterials, 63 (2015) 128-136.

15. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for theimaging of nitric oxide in mitochondria”,Biomaterials, 58 (2015) 72-81.

Biomaterials, 56 (2015) 140-153.

17. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”,Biomaterials, 53 (2015) 522-531.

18. Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu,Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”,Biomaterials, 53 (2015) 285-295.

19. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”,Biomaterials, 35 (2014) 9003-9011.

20. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for speciﬁc mitochondrial imaging and tracking”,Biomaterials, 35 (2014) 2-13.

21. Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”,ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.

ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.

23. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”,ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.

24. Cheng Ouyang,Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”,Chem. Commun., 2018, DOI: 10.1039/C8CC02795A.

25. Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”,Chem. Commun., 54 (2018) 2421-2424.

26. Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent andphotodynamictherapeutics”,Chem. Commun., 53 (2017) 12341-12344.

27. Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”,Chem. Commun., 53 (2017) 10374-10377.

28. Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”,Chem. Commun., 53 (2017) 9878-9881.

29. Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”,Chem. Commun., 53 (2017) 2052-2055.

30. Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatableruthenium(II)-azo photosensitizerfor two-photon photodynamic therapy”,Chem. Commun., 53 (2017) 1977-1980.

31.Bole Yu,Ying Chen,Mei Hong,Pingping Duan,Shifeng Gan,Hui Chao*,Zujin Zhao*,Jing ZhaoChem Commun., 51 (2015) 14365-14368.

32. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”,Chem. Commun., 50 (2014) 2123-2125.

33. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li,Chunyuan Liu,Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”,Chem. Commun., 49 (2013) 11095-11097.

34. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”,Chem. Commun., 49 (2013) 2040-2042.

35. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as atracking non-viral gene vector”,Chem. Commun., 49 (2013) 810-812.

36. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”,Chem. Commun., 48 (2012) 10781-10783.

J. Med. Chem., 57 (2014) 8971-8983.(Highlight as Highly Cited Article of 2014 of J Med Chem)

38. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”,J. Med. Chem., 56 (2013) 6531-6535.

39. Shanshan Zou, Guanying Li, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, “Interfering DNA high-order structures with chiral ruthenium(II) complexes”,Chem. Eur. J.,24 (2018) 690-698.

Chem. Eur. J.,23 (2017) 9888-9896.(VIP Article, Highlight on ChemistryViews “Fighting Cancer with Ruthenium Complexes”)

41. Lingli Sun, Yu Chen, Shi Kuang, Guanying Li, Ruilin Guan, Jiangping Liu, Liangnian Ji, Hui Chao*, “Iridium(III) Anthraquinone Complexes asTwo-photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia”,Chem. Eur. J., 22 (2016) 8955-8965.(Hot paper).

42. Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II)Anthraquinone Complexes ExhibitStrong Anticancer Activity inHypoxic Tumor Cells”,Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”)

43. Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”,Chem. Eur. J. 21 (2015) 12000-12010.(Highlight as Frontispiece)

44. Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”,Chem. Eur. J., 21 (2015) 4008-4020.

45. Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes asTwo-Photon Luminescent Tracking Non-Viral Gene Vectors”,Chem. Eur. J., 21 (2015) 3691-3700.

46. Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”,Chem. Eur. J., 21 (2015) 715-725.

47. Pingyu Zhang†,Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+detection”,Chem. Eur. J., 19 (2013) 15494-15503.(Highlight as Frontispiece)

相关成果

先后在《Chem.Soc. Rev》、《Coord.Chem. Rev》、《PNAS》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《ACS Appl. Mater. Interfaces》、《Chem. Commun.》、《J. Med. Chem.》、《Chem. Eur. J》等国际期刊发表第一作者或通讯作者SCI论文163篇，论文被引用4600多次。参编著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德国 John Wiley & Son出版公司出版, 2005年)和“生物无机化学导论”（第三版）（科学出版社，2010年）。申请中国发明专利16件, 授权12件。担任中国化学会化学生物学专业委员会委员、《Scientific Reports》编委、《Journal of Inorganic Biochemistry》编委、《大学化学》编委。

获奖情况

2001年获中国高校自然科学奖二等奖（第九完成人）

2005年获中国化学会“青年化学奖”

2006年入选教育部“新世纪优秀人才支持计划”

2006年入选广东省高等学校“千百十工程”人才培养计划（校级）

2007年获中山大学化学与化工学院“53奖教金”

2011年获广东省科学技术奖一等奖（第二完成人）

2011年被评为中山大学校级教学名师

2012年获国家自然科学奖二等奖（第三完成人）

2012年获中山大学第七届校级教学成果奖一等奖（第一完成人）

2012年获中山大学第七届校级教学成果奖一等奖（第四完成人）

2012年被评为南粤优秀教师（广东省）