张新歌

南开大学副教授

张新歌女，籍贯河南省。学历博士，南开大学副教授，二级学科，高分子化学与物理，所在单位高分子化学研究所，毕业院校南开大学。

人物经历

2003年毕业于天津师范大学，获得硕士学位。

2006年毕业于南开大学，获得博士学位。

同年毕业留高分子所工作至今。

目前还担任Biomacromolecules, Molecular Pharmaceutics, Nanomedicine-UK, International Journal of Pharmaceutics, Carbohydrate Polymers, Carbohydrate Research, Journal of Biomaterials Science, polymer Edition, Drug News and Perspectives, European Journal of Chemistry, Asian Journal of Pharmaceutics, Current Drug Delivery等国际期刊审稿人。

研究方向

生物医用高分子研究、药物传递、细胞支架的设计与合成、智能高分子材料研究；

具有特殊链构造的非线型生物高分子设计与合成；

基于多肽、多糖和生物可降解性高分子的生物医用材料；

光、磁、热、糖和 pH 响应性环境敏感智能材料；

药物缓释、控释及生物活性物质传输的载体材料；

环境响应性无机/有机杂化纳米材料；

抗菌高分子材料；

主要贡献

研究成果发表在Biomaterials，Journal of Controlled Release, Biomacromolecules，Acta Biomaterialia，Polymer，European Journal of Pharmaceutics and Biopharmaceutics，New Journal of Chemistry，Carbohydrate Polymers, Journal of Colloid and Interface Science等期刊上，共发表SCI论文30余篇。

科研项目

1.天津市自然科学基金：生物大分子药物黏膜智能化给药的纳米载体材料研究（已结题）；

2.国家自然科学基金：新型含生物黏附性和酶抑制活性两亲性高分子药物载体材料的研究（2009.1-2011.12）；

3.教育部博士点基金：新型鼻腔给药载体材料的研究（2009.1-2011.12）；

4.国家自然科学基金：用于铜绿假单胞菌识别拓扑生物高分子的构建及其与蛋白质相互作用研究（2012.1-2015.12）；

研究成果

1.Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li, Zhen Wang. A novel hydrotropic β-cyclodextrin grafted hyperbranched polyglycerol copolymer for hydrophobic drug delivery. Acta Biomaterialia 2011, 7:585-592.

2. Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li*,Zhen Wang. β-Cyclodextrin grafted hyperbranched polyglycerols as carriers for nasal insulin delivery. Carbohydrate Polymers 2011, 84:1419-1425.

3.Shujun Shu, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery. Biomaterials 2010, 31(23):6039-6049.

4.Teng Dayong, Wu Zhongming, Zhang Xinge*, Zhang shaomin, Zheng Chao, Wang Zhen, Li Chaoxing*. Synthesis and characterization of in situ cross-linked hydrogel based on self-assembly of thiol-modified chitosan with PEG diacrylate using Michael type addition. Polymer 2010, 51:639-646.

5.Shujun Shu, Chunyang Sun, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery. Acta Biomaterialia 2010, 6:210-217.

6.Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li*. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery. Journal of Controlled Release 2009, 140:141-147.

7.Shujun Shu, Xin Wang, Xinge Zhang*, Zhen Wang, Chaoxing Li*. Disulfide cross-linked biodegradable polyelectrolyte nanoparticles as oral protein drugs delivery. New Journal of Chemistry 2009, 33:1882-1887.

8.Xingju Jin, Xinge Zhang*, Zhongmin Wu, Dayong Teng, Xuejiao Zhang, Yanxia Wang, Zhen Wang, Chaoxing Li*. Amphiphilic random glycopolymer based on phenylboronic acid: Synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules 2009, 10:1337-1345.

9.Xinge Zhang*,Zhongming Wu, Xiujun Gao, Shujun Shu, Huijie Zhang, Zhen Wang, Chaoxing Li. Chitosan bearing pendant cyclodextrin as a carrier for controlled protein release. Carbohydrate Polymers 2009, 77:394-401.

10.Dayong Teng, Jingli Hou, Xinge Zhang*, Xin Wang, Zhen Wang, Chaoxing Li*. Glucosamine-carrying temperature- and pH-sensitive microgels: preparation, characterization and in vitro drug release studies. Journal of Colloid and Interface Science 2008, 322: 333-341.

11.Xinge Zhang, Huijie Zhang, Zhongming Wu, Zhen Wang, Haimei Niu, Chaoxing Li. Nasal absorption enhancement of insulin by using PEG-g-chitosan nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 2008, 68(3):526-534.

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