微生物生物化学

研究微生物生命活动的化学基础和生物化学过程的微生物学分支学科。

乔治北·科恩( Georges N. Cohen)

Microbial Biochemistry covers the principles of bacterial growth, as well as the description of the different layers that enclose the bacterialcytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. 微生物生物化学包括细菌的生长原理，以及细胞质中描述的不同层次的细菌包围，他们的详细作用机制在不同渗透率描述通过媒体获得养分从外面。 A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. 阿章介绍变构，是不可或缺的书描述整个监管机制的理解很多。 Another section analyses the mechanisms by which cells obtain the energy necessary for their growth,glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. 另一部分分析机制，细胞周期中获得所需能量anaplerotic为他们的成长，糖酵解，戊糖磷酸途径，在三羧酸和。

Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs.两章是专门处理很少在教科书中的微生物类，即古细菌，主要是产甲烷细菌和methylotrophs。 The book also describes the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation.书中还介绍了在转录水平本条例的原则，在转录和翻译机器所需的知识。 There are chapters that deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12.有章，随着细胞的基石，氨基酸，嘌呤和嘧啶核苷酸和deoxynucleotides，水溶性维生素和辅酶，异戊二烯和四吡咯衍生物和维生素B12的合成处理。

And the two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways.而最后两个章节是专门用于蛋白质- DNA相互作用的研究以及对生物合成途径的进化。 The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.在该领域在过去三十年由基因的克隆和测序，并通过引进，如X -射线晶体学和核磁共振物理方法开发了相当大的进步指数已帮助下提交了多学科的角度有吸引力的代谢。

Microbial Biochemistry is an outstanding reference for graduate students and researchers in Academia and industry. 微生物生物化学是一个与行业优秀研究生学术参考学生和研究人员研究。

微生物生物化学 - Contents 目录

Introduction简介

Bacterial Growth细菌生长

The Outer Membrane of Gram-negative Bacteria and the Cytoplasmic Membrane革兰阴性菌的外膜和细胞质膜

Peptidoglycan Synthesis肽合成

Cellular Permeability细胞通透性

Allosteric Enzymes变构酶

Glycolysis, Gluconeogenesis and Glycogen Synthesis糖酵解，糖异生和糖原的合成

The Pentose Phosphate and Entner-Doudoroff Pathways戊糖磷酸和恩特纳- Doudoroff途径

The Tricarboxylic Acid Cycle and the Glyoxylate Bypass三羧酸循环和乙醛酸绕道

Biosynthesis of Lipids合成脂质

The Archaea古细菌

Methanogensand Methylotrophs甲烷菌和Methylotrophs

Enzymen Induction in Catabolic Systems Enzymen诱导系统的生理作用

Transcription.转录。 RNA Polymerase RNA聚合酶

Negative Regulation负调控

Enzyme Repression in Anabolic Pathways酶蛋白同化途径镇压

Positive Regulation正调控

The Ribosomes核糖体

The Genetic Code, the Transfer RNAs and the aminoacyl-tRNA-synthetases遗传密码，转让的RNA和氨酰- tRNA -合成酶

The Biological Fixation of Nitrogen生物固定的氮

How Biosynthetic Pathways Have Been Established如何建立了生物合成途径

The Aspartic Acid Family of Amino Acids.的氨基酸天门冬氨酸的家庭。 Biosynthesis生物合成

Regulation of Biosynthesis of the Amino Acids of the Aspartic Acid Familiy in Enterobacteriaceae酸家风调控的天门冬氨酸生物合成的氨基酸肠杆菌科

Other Patterns of Regulation of the Synthesis of Amino Acids of the Aspartate Family对了对天冬氨酸族氨基酸合成调控等图案

Biosynthesis of the Amino Acids of the Glutamic Acid Family and Its Regulation生物合成的谷氨酸和氨基酸的家庭及其规制

Biosynthesis of Amino Acids Derived from Phosphoglyceric Acid and Pyruvic Acid氨基酸生物合成磷酸甘油酸和衍生丙酮酸

Selenocysteine and Selenoproteins硒及硒蛋白

Biosynthesis of Aromatic Amino Acids and Its Regulation芳香族氨基酸生物合成及其调控

The Biosynthesis of Histidine and Its Regulation组氨酸生物合成及其调控

The Biosynthesis of Nucleotides生物合成的核苷酸

The Biosynthesis of Deoxyribonucleotides生物合成的Deoxyribonucleotides

Biosynthesis of Some Water-Soluble Vitamins and of their Coenzyme Forms生物合成的一些水溶性维生素和辅酶的形式

Biosynthesis of Carotene, Vitamin A, Sterols, Ubiquinones, and Menaquinones生物合成的胡萝卜素，维生素A，甾醇，Ubiquinones和Menaquinones

Biosynthesis of the Tetrapyrrole Ring System生物合成的四吡咯环系统

Biosynthesis of Cobalamins including Vitamin B 12 Cobalamins包括合成维生素B 12

Interactions between Proteins and DNA蛋白质和DNA之间的相互作用

Evolution of Biosynthetic Pathways生物合成途径的演变

缩略语

Subject Index主题索引

在第一部分中，细菌生长的原则，给出以及该细菌的细胞质中附上不同层次的描述，以及它们在不同渗透率获得通过，详细描述的机制，向境外媒体营养物质的作用。 A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book.阿章介绍变构，负责整个书中描述的许多监管机制的理解是必不可少的。 Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles.另一部分分析细胞的机制，取得他们的成长，糖酵解，戊糖磷酸途径，在三羧酸和anaplerotic周期所需能量。 Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs.两章是专门处理很少在教科书中的微生物类，即古细菌，主要是产甲烷细菌和methylotrophs。 Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation.八个章节描述在转录水平本条例的原则，在转录和翻译机器所需的知识。 The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12.接下来的15章处理单元格的基石，氨基酸，嘌呤和嘧啶核苷酸和deoxynucleotides，水溶性维生素和辅酶，异戊二烯和四吡咯衍生物和维生素B12的合成。 The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways.最后两章专门讨论在蛋白质与DNA相互作用的研究以及对生物合成途径的进化。 The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.在该领域在过去三十年由基因的克隆和测序，并通过引进，如X -射线晶体学和核磁共振物理方法开发了相当大的进步指数已帮助下提交了多学科的角度有吸引力的代谢。 The level ofreadershippresupposes some knowledge of chemistry and genetics at the undergraduate level.读者水平的先决条件是本科层次的一些化学和遗传学知识。 The target group is graduate students, researchers in academia and industry.其对象是研究生，在学术界和工业界的研究人员。