曾进胜

中山大学附属第一医院副院长

曾进胜，男，1964年出生。现任中山大学附属第一医院副院长，广东省重大神经疾病诊治研究重点实验室主任，国家重点学科-中山大学附属第一医院神经科主任、二级教授、一级主任医师、博士生导师。广东省“珠江学者”特聘教授。

人物经历

1985年毕业于江西医学院医疗系。

1994年获中山医科大学神经病学专业博士学位。

1996年9月至1998年8月在瑞典LUND大学Wallenberg神经科学中心从事博士后研究。

2002年7月至2002年10月在NNICU, Barnes-Jewish Hospital, Washington University in St. Louis. USA，学习脑卒中监护和急救。

2020年12月，预备党员曾进胜同志转为正式党员。

主要成就

科研成就

科研综述

主要从事脑血管病的预防、急救、治疗和康复研究，在脑卒中后神经可塑性、内源性神经干细胞的分化和远隔性损害研究方面具有特色。其中高血压动脉硬化性脑梗死的病理机制及临床系列研究和抗高血压治疗预防脑卒中的实验研究分别获广东省科技进步二等奖、卫生部三等奖和广东省医药卫生科技进步二等奖。曾被卫生部医政司评为卫生部支援西部地区农村卫生工作“优秀教师”，获国家教育部“高校青年教师奖”、广东省回国创业青年之星“优秀奖”、国家教育部高等院校优秀青年教师“霍英东教育基金三等奖”和广东省青年教师“南粤教坛新秀奖”、广东省优秀教师奖、柯麟医学奖，入选“千百十人才工程”广东省级培养对象并获优秀个人称号、广东省“珠江学者”特聘教授。承担并完成教育部高校青年教师奖励计划（TRAPOYT，2002年）、国家自然科学基金（39940012, 30271485，30770764）、卫生部临床学科重点学科建设项目（2002）、美国中华医学会基金（CMB，00-730）、广东省自然科学基金（990065，B30303, 2003D30301）和广东省自然科学基金团队项目（2000年）等多项科研项目30项。已在国内外杂志发表论文270篇，其中SCI收录杂志51篇。主编专著4本，参与编写专著20本。

医疗特长

脑血管病的预防、急救、治疗和康复，在脑卒中后神经可塑性、内源性神经干细胞的分化和远隔性损害研究方面具有特色。

科研成果

已完成国家、省部和地市级科研项目41项（包括国家重点研发计划慢病项目、国家自然科学基金联合重点项目和973课题），正承担国家自然科学基金重点项目，已发表论文400余篇，其中SCI收录166篇。主编专著8本，参与编写专著32本。

发表论文

1. 方燕南,曾进胜，代谢综合征与脑卒中.继续医学教育, 2005

2. 姚晓黎,李洵桦,曾进胜，提高教学能力,讲好本科大课.中山大学学报论丛, 2007

3. 冯慧宇,方燕南,姚晓黎,车珠江,曾进胜，现代教育技术在神经科教学中的应用.中山大学学报论丛, 2007

4. 陈子怡, 陶玉倩, 李洵桦, 冯慧宇, 周列民, 曾进胜，以理论考核分析指导神经科见习方案调整.医学信息, 2009

5. 李中, 王淑珍, 张成，李洵桦, 曾进胜，提高临床神经病学见习教学质量的探索与实践.西北医学教育, 2009

6. 张为西，曾进胜，洪华，等.现代教育技术在神经病学教学中应用情况的调查分析.中山大学学报论丛, 2010

出版图书

主参编教材

1. 主编《脑卒中:新理论与新实践1》(2006年)

2. 主编《脑卒中:新理论与新实践2》(2008年)

3. 主编《脑卒中:新理论与新实践3》(2009年)

4. 主编《临床诊断与治疗方案丛书;神经内科疾病》(2010年)

5. 副主编《神经病学》(2009年)

6. 副主编《神经病学》（2010年）

7. 副主编《临床专科医师规范化培训用书—神经病学》（2009年）

8. 参编《内科临床手册》(2006年)

9. 参编《神经病学》(第2版) (2007年)

10.参编《内科急症治疗学》(2009年)

科研工作

科研成果

主要从事脑血管病的防治和康复机制研究，1998年回国后，在国内首先开创了脑中风监护工作。近年的主要成绩有：

研究成果获奖等级时间排名

1．脑梗塞的病理机制及治疗新理念广东省科技进步二等奖 2008 第三

2．易卒中型肾血管性高血压大鼠模型及其应用教育部科技进步二等奖 2007 第二

SCI收录的部分论文(*为通信作者)

1. Jinsheng Zeng (曾进胜)*, Huang R. Stroke-prone Renovascular Hypertensive Rats.Chinese Medical Journal, 1998, 111(8):741-744

2. Jinsheng Zeng(曾进胜)*, Zhang Y, Mo J, Su Z, Huang R. Two-Kidney two-clip renovascular hypertensive rats can be used as stroke-prone rats. Stroke , 1998, 29(8):1708-1714

3. Jinsheng Zeng (曾进胜) *, Zhang Y, Mo J, Su Z, Huang R. Spontaneous stroke in renovascular hypertensive rats. Stroke, 1999, 30:696

4. Jinsheng Zeng(曾进胜), Mattsson B, Johansson BB. Are neuronal markers and neocortical graft-host interface influenced by housing conditions in rats with cortical infarct cavity? Brain Res Bull. 1999，48:165-171

5. Risedal A, Jinsheng Zeng (曾进胜), Johansson BB. Early training may exacerbate brain damage in focal brain ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19:997-1004

6. Jinsheng Zeng(曾进胜), Mattsson B, Schultz M, Johansson BB, Sorensen JC. Expression of zinc positive cells and terminals in fetal homografts to adult rat neocortex depend on transplantation site and rearing conditions. Exp Neurol, 2000, 164:176-183

7. Yannan Fang, Xiaohua Chen, Hua Li, Jianwen Lin, Ruxun Huang, Jinsheng Zeng(曾进胜). A study on additional early physiotherapy after stroke and factors affecting functional recovery. Clinical Rehabilitation. 2003, 17(6):608-617

8. Jinsheng Zeng(曾进胜)*, Yu Jian, Cui Chunmei, Zhao Zhan, Hong Hua, Sheng Wenli, Tao Yuqian, Li Ling, Huang Ruxun. Cultured human embryonic neocortical cells survive and grow in infarct cavities of adult rat brains and interconnect with host brain. Chinese Medical Journal，2005, 118(4):275-280

9. Hong H, Jin-sheng Zeng(曾进胜), Kreulen DL, Kaufman DI, Chen AF. Atorvastatin ProtectsAgainst Cerebral Infarction via Inhibiting NADPH Oxidase-Derived Superoxide in Ischemic Stroke. Am J Physiol Heart Circ Physiol, 2006, 291(11):2210-2215

10. Bin Song, Chi Ma, Shoufang Gong, Zhongmin Yuan, Dan Li, Wei Liu,Wenming Li, Ruzhu Chen, Xiaonan Zhu, Jinsheng Zeng(曾进胜), Yifan Han, Mingtao Li. Extracellular signal-regulated kinases are not involved in activitydependent survival or apoptosis in cerebellar granule neurons. Neuroscience Letters, 2006, 407(8):214–218

11. Chunmei Cui, Alex F Chen, Zongpei Jiang, Qingqing Wu,Jianwen Lin, Hongmei Wen and Jinsheng Zeng(曾进胜)*. Inhibition of NAD(P)H oxidase reduces fibronectin expressionin stroke-prone renovascular hypertensive rat brain. Clinical and Experimental Pharmacology and Physiology, 2007, 34(4):304-309

12. Zhijian Liang, Jinsheng Zeng(曾进胜)*, Siren Liu, Xueying Ling,Anding Xu, Jian Yu, Li Ling. A prospective study of secondary degeneration following subcortical infarction using diffusion tensor imaging. J Neurol Neusurg Psychiat, 2007, 78(5):581-586

13. Fang Wang, Zhijian Liang, Qinghua Hou, Shihui Xin, Li Lin, Meixia He, Zhong Pei，Jinsheng Zeng(曾进胜)*. Nogo-A is involved in secondary axonal degeneration of thalamus in hypertensive rats with focal cortical infarction. Neuroscience Letters, 2007, 417 (3) :255–260

14. Zhan Zhao, Jian Yu, Songjie Liao, Li Xiong, Zhijian Liang, Li Ling, Qinghua Hou, Wenliang Zhou, Zhong Pei, Jinsheng Zeng(曾进胜)*.Delayed Decompressive Craniectomy Improves the Long term Outcome in Hypertensive Rats with Space-occupying Cerebral Infarction. Neurocritical Care, 2007, 7(3):263-269

15. Chun-Ling Liu, Song-Jie Liao, Jin-Sheng Zeng(曾进胜), Jian-Wen Lin, Chang-Xin Li，Long-Chang Xie,Xiao-Geng Shi,Ru-Xun Huang. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. Journal of the Neurological Sciences, 2007, 260(4):106–113

16. Song-Jie Liao, Li Lin, Jin-Sheng Zeng(曾进胜), Ru-Xun Huang, Keith MChannon., Alex F Chen. Endothelium-Targeted Transgenic Gtp-Cyclohydrolase I Overexpression Inhibits Neointima Formation In Mouse Carotid Artery. Clinical and Experimental Pharmacology and Physiology, 2007, 34(12):1260-6.

17. Meixia He, Shihui Xing, Bo Yang, Liqun Zhao, Ying Hai, Zhijian Liang, Wenliang Zhou, Jinsheng Zeng(曾进胜)*, Zhong Pei. Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats. Brain Research, 2007, 1181:83-92

18. Zhijian Liang, Jinsheng Zeng(曾进胜)*, Cuimei Zhang, Sirun Liu, Xueying Ling, Anding Xu, Li Ling, Fang Wang, Zhong Pei. Longitudinal Investigations on the Anterograde and Retrograde Degeneration in the Pyramidal Tract following Pontine Infarction with Diffusion Tensor Imaging. Cerebrovascular Diseases, 2008, 25(3):209-216

19. Li Ling, Qinghua Hou, Shihui Xing, Jian Yu, Zhong Pei, Jinsheng Zeng(曾进胜)*. Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats. Brain Research, 2008, 1206(4):89-97

20. Yining Huang, Yan Cheng, Jiang Wu, Yansheng Li, En Xu, Zhen Hong, Zhengyi Li, Weiwei Zhang, Meiping Ding, Xuguang Gao, Dongsheng Fan, Jinsheng Zeng(曾进胜), Kasing Wong, Chuanzhen Lu, Jiangxi Xiao, Chen Yao. Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol, 2008, 7(6): 494–99.

21. Shihui Xing, Ling Chen, Xi Chen, Zhong Pei, Jinsheng Zeng(曾进胜) * Jinru Li. Excessive blinking as an initial manifestation of juvenile Huntington’s disease from a Chinese family. Neurological Science, 2008, 29:275–277

22. Shihui Xing, Yangdong He, Li Ling, Qinghua Hou, Jian Yu, Jinsheng Zeng(曾进胜)*,Zhong Pei. Blockade of EphB2 enhances neurogenesis in the subventicular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Brain Research, 2008, 1230:237-246.

23. Zhongwei Zhang, Laijing Song, Quanfei Meng, Ziping Li, Boning Luo, Zhong Pei, Jinsheng Zeng(曾进胜). Segmented echo planar MR imaging of the brachial pexus with inversion recovery magnetization preparation at 3.0T. Journal of Magnetic Resonance Imaging , 2008, 28(2):440–444

24. Yuhua Fan, Liangfu Zhu, Songjie Liao, Jinsheng Zeng(曾进胜)*. Anxiety disorders mimic recurrent transient ischemic attacks: Two case reports. American Journal of Case Report. 2008, 9(4):196-199

25. Li Ling, Xiaoshun He, Jinsheng Zeng(曾进胜)*. In-Hospital Cerebrovascular Complications following orthotopic Liver Transplantation. BMC Neurology, 2008, 8:52

26. Jian Yu, Jinsheng Zeng(曾进胜)*, Yangdong He, Zhan Zhao, Chunmei Cui, Li Xiong, Meixia He, Zhijian Liang, Hua Hong, Wenli Sheng, Yannan Fang, Ruxun Huang, Ramond Cheung. Exogenous epidermal growth factor improves early neurological function and promotes endogenous subependymal neural stem cells differentiation to astrocytes in adult hypertensive rats after neocortical infarction. Clinical and Experimental Pharmacology and Physiology, 2009, 36, 539–546

27. Yongjing Su, Xiaoyan Zhang, Jinsheng Zen(曾进胜)*, Zhong Pei, Raymond Tak Fai Cheung, Qiuping (Pearl) Zhou, Li Ling, Jian Yu, Jianling Tan, Zhenlu Zhang. New-onset constipation at acute stage after first stroke： incidence, risk factors, and impact on the stroke outcome. Stroke, 2009,40(4):1304-9.

28. Yuhua Fan, Songjie Liao, Jian Yu, Li Ling, Qinghua Hou, Shihui Xing, Jinsheng Zeng(曾进胜)*. Idiopathic hypertrophic cranial pachymeningitis manifested by transient ischemic attack. Medical Science Monitor, 2009; 15(12): CS 178 - 181

29. Zhijian Liang, Jinsheng Zeng(曾进胜)*, Cuimei Zhang, Sirun Liu, Xueying Ling, Fang Wang, Li Ling, Qinghua Hou, Shihui Xing, Zhong Pei. Progression of pathological changes in the middle cerebellar peduncle by diffusion tensor imaging correlate with lesser motor gains after pontine infarction. Neurorehabilitation and Neural Repair, 2009, 23(7):692-698

30. Li Ling, Jinsheng Zeng(曾进胜)*, Zhong Pei, Raymond Tak Fai Cheung, Qinghua Hou, Shihui Xing, Jian Yu. Neurogenesis and angiogenesis in ipsilateral thalamus with secondary damage in adult hypertensive rats following focal cortical infarction. Journal of Cerebral Blood flow and Metabolism, 2009, 29:1538–1546

31. Li Ling, Liangfu Zhu, Jinsheng Zeng(曾进胜)*, Songjie Liao, Jian Yu, Zhiyun Yang, Zhijian Liang. Pontine infarction with pure motor hemiparesis or hemiplegia. BMC Neurology, 2009, 15;9:25

32. Jian Sun, Yannie Oi Yan Soo , Wynnie Wai Man Lam, Ka Sing Wong, Jin Sheng Zeng, Yu Hua Fan. Different distribution patterns of cerebral microbleeds in acute ischemic stroke patients with and without hypertension. Eur Neurol, 2009, 62:298–303

33. Song-Jie Liao, Jian-Wen Lin, Zhong Pei, Chun-Ling Liu, Jin-sheng Zeng(曾进胜), Ru-Xun Huang. Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP. Brain Res, 2009, 1289:69-78.

34. Jia Zhao, Ling Li, Chen Ling, Jie Li, Ji-Yan Pang, Yong-Cheng Lin, Jie Liu, Ruxun Huang, Guan-Lei Wang, Zhong Pei and Jinsheng Zeng(曾进胜). Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res, 2009, 1302:240-247.

35. Qinghua Hou, Li Ling, Fang Wang, Shihui Xing, Zhong Pei, Jinsheng Zeng(曾进胜)*. Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke. Brain Research, 2010, 1311:182-188

36. Mei-xiaHe, Wan-liYang, Ming-mingZhang, Ya-junLian, Hai-yingHua, Jin-sheng Zeng(曾进胜), Li-rongZhang. Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease. Neurol Sci, 2010, 31(2):165-8.

37. Xi-lin Lu, Xiao-li Yao, Zhiyong Liu, Heng Zhang, Wei Li, Zhenxing Li, Guan-Lei Wang, Jiyan Pang, Yongcheng Lin, Zhongliang XuLing Chen, Zhong Pei Jinsheng Zeng(曾进胜)*. Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res, 2010, 1332:110-9.

38. Li Xiong, Jian Yu, Songjie Liao, Shihui Xing, Zhan Zhao, Jinsheng Zeng(曾进胜)*. Mechanisms of secondary damage to the thalamic nucleus and substantia nigra in an adult hypertensive rat model following middle cerebral artery occlusion Neural Regen Res, 2010, 5(11):853-858

39. Yusheng Zhang, Shihui Xing, Jian Zhang, Jingjing Li, Chuo Li, Zhong Pei and Jinsheng Zeng(曾进胜)*. Reduction of β-amyloid deposits by γ-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats. Journal of Cerebral Blood flow and Metabolism, 2011, 31(2):572-9

40. Chuo Li, Xueying Ling, Sirun Liu, Anding Xu, Yusheng Zhang, Shihui Xing, Zhong Pei and Jinsheng Zeng*(曾进胜). Early detection of secondary damage in ipsilateral thalamus after acute infarction at unilateral corona radiata by diffusion tensor imaging and magnetic resonance spectroscopy. BMC Neurology. 2011, 11:49.

41. Jing-Jing Li, Shi-Hui Xing, Jian Zhang, Hua Hong, Yi-Liang Li, Chao Dang, Yu-Sheng Zhang, Chuo Li, Yu-Hua Fan, Jian Yu, Zhong Pei and Jin-Sheng Zeng*(曾进胜). Decrease of tight junction integrity in the ipsilateral thalamus during the acute stage after focal infarction and ablation of the cerebral cortex in rats. Clinical and Experimental Pharmacology and Physiology. 2011,38:776–782.

42. Zhang J, Zhang Y, Li J, Xing S, Li C, Li Y, Dang C, Fan Y, Yu J, Pei Z and Jin-Sheng Zeng*(曾进胜). Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats. J Neurochem. 2012;120(4):564-73.

43. Xing S, Zhang Y, Li J, Zhang J, Li Y, Dang C, Li C, Fan Y, Yu J, Pei Z and Jin-Sheng Zeng*(曾进胜). Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. Autophagy. 2012;8(1):63-76.

44. Zhang J, Zhang Y, Xing S, Liang Z and Jin-Sheng Zeng*(曾进胜). Secondary neurodegeneration in remote regions after focal cerebral infarction: a new target for stroke management? Stroke. 2012;43(6):1700-5.

45. Li C, Ling X, Liu S, Xu A, Zhang Y, Xing S, Pei Z and Jin-Sheng Zeng*(曾进胜). Abnormalities of magnetic resonance spectroscopy and diffusion tensor imaging are correlated with executive dysfunction in patients with ischemic leukoaraiosis. J Clin Neurosci. 2012;19(5):718-22.

46. Wang F, Xing S, He M, Hou Q, Chen S, Zou X, Pei Z, Zeng J. Nogo-A is associated with secondary degeneration of substantia nigra in hypertensive rats with focal cortical infarction. Brain Res. 2012;1469:153-63.

47. Dang C, Liu G, Xing S, Xie C, Peng K, Li C, Li J, Zhang J, Chen L, Pei Z and Jin-Sheng Zeng*(曾进胜). Longitudinal cortical volume changes correlate with motor recovery in patients after acute local subcortical infarction. Stroke. 2013;44(10):2795-801.

48. Xing S, Zhang J, Dang C, Liu G, Zhang Y, Li J, Fan Y, Pei Z and Jin-Sheng Zeng*(曾进胜).Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction. J Neurol Sci. 2014;337(1-2):104-11.

人才培养

主要课程

课程名称课程类别年学时届数学生总人数

脑血管疾病与偏头痛（英文）七、八年制临床医学专业课 4学时/年 5 500

脑血管疾病新进展（中文）研究生学位专业课 4学时/年 5 100

脑血管疾病新进展（中文）全国高级医师进修班 4学时/年 5 150

实践性教学

指导实习生的教学,在查房时将神经病学的基础理论和临床实际紧密结合为学生进行讲解. 将神经病学、神经解剖、血管解剖、康复医学相结合，使学生掌握神经解剖、血管解剖的基础上，学习神经病学。同时指导研究生的课题设计;对每个毕业生的论文进行审核.在实践中对教学进行大胆改革,树立以学生为主体的教学思想，充分发挥学生主动学习的积极性。

教学研究课题

1. 2003-2007年，第一负责人，“脑卒中专科化治疗和神经可塑性研究”项目，教育部高校青年教师奖

2. 2007- 2009年，第一负责人，主持“07校级双语课程《神经病学》”项目，中山大学医学教务处

荣誉表彰

连续两年被卫生部医政司评为“支援西部地区农村卫生工作优秀教师”，先后获“全国优秀讲师”、广东省“南粤优秀教师奖”、广东省优秀青年教师“南粤教坛新秀”奖、中山医科大学“文鹏凌夫妇”教学优秀奖、教育部高等院校优秀青年教师“霍英东教育基金”三等奖和教育部高校青年教师奖等。

社会任职

担任中国神经精神疾病杂志主编、International Journal of Stroke(中文版)主编、中国卒中杂志副主编、中华脑血管病杂志(电子版)副总编辑和美国Stroke杂志、国内12家专业杂志编委和Brain Research、Cerebrovascular Diseases等杂志审稿人、中华预防医学会卒中预防与控制委员会副主任委员、中华医学会神经病学分会委员、脑血管病学组秘书、中国医师协会神经病学分会常委、广东省医师协会神经病学分会主任委员、广东省神经内科学会副主任委员、脑血管病学组组长。

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