李沉简

北京大学元培学院原常务副院长

李沉简，男，1969年10月生，前任北京大学元培学院常务副院长、生命科学学院教授。

学术经历

1984年至1987年就读于北京大学生物系医预班，

1987年至1988年在北京协和医学院学习基础医学，

1997年博士毕业于美国普度大学神经生物及分子遗传专业。

工作经历

1997年至2003年在美国纽约Rockefeller大学从事博士后研究工作，

2003年至2009年在美国康奈尔大学医学院任助理教授，

2009年至2010年在美国康奈尔大学医学院任副教授，

2010年至今在美国纽约大学西奈山医学院任讲席教授。

现任北京大学生命科学学院教授。

2016年任北京大学元培学院常务副院长。

代表性论文

1. Zheng, S.,Geghman, K., Shenoy, S., Li, C , Retake the Center Stage - New Development of Rat Genetics. , Journal of Genetics and Genomics. , 2012 , 39(6):261-8.

2. Yong Huang and Chenjian Li , Proteasome dysfunction in animal models for PINK1 Parkinson’s disease , J Neurogenetics , 2012 , 26(2):158-67

3. Qing Xu, Sushila Shenoy and Chenjian Li , Mouse Models for LRRk2 Parkinson’s Disease , Parkinsonism and Related Disorders , 2012 , 18, 186-189.

4. Dagda R, Gusdon A, Pien I, Strack S, C Li, Cherra J, and Chu C. , Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. , Cell Death and Differentiation. , 2011 , 18, 1914-1923.

5. Kindiya Geghman and Chenjian Li , ractical consideration of genetic rodent models for neurodegenerative disease. , Methods in Mol Biol. , 2011 , 793:185-193.

6. Wencheng Liu, Rebeca Acin-Perez, Kindiya Geghman, Giovanni Manfredi, Bing Wei Lu and Chenjian Li , Pink1 regulates the assembly of oxidative phosphorylation machinery via mitochondrial fission , Proc Natl Acad Sci.USA. , 2011 , 108, 12920-12924.

7. Cristofol Vives-Bauza, Chun Zhou, Yong Huang, VAlina Dawson, Darren More, Grailhe, Ted Dawson, Chenjian Li, Serge Przedborski. , PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. , Proc Natl Acad Sci. USA. , 2010 , 107, 378-383.

8. Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acin-Perez, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrane, , Mihaela Stavarache, Michael Kaplitt, Xin-Yun Huang, M. Flint Beal, Giovanni Manfredi and Chenjian Li , Mutant PINK1 causes mitochondrial dysfunction, proteasomal deficit and α-synuclein aggregation in Parkinson’s disease models. , PLoS ONE. , 2009 , 4(2): e4597.

9. Yanping Li, Wencheng Liu, Tinmarlar F. Oo, Lei Wang, Yi Tang, Vernice Jackson-Lewis, Chun Zhou, Kindiya Geghman, Serge Przedborski, M.Flint Beal Robert Burke and Chenjian Li , BAC transgenic mouse model for LRRK2 recapitulates robust Parkinson’s disease phenotypes. , Nature Neuroscience. , 2009 , 12, 826-828.

10. Younghwa Kim, Ping Zhou, Liping Qian, Jesica Lee, Chenjian Li, Constantino Iadecola, Carl Nathan and Aihao Ding. , MyD88-5 links mitochondra, microtubules and JNK3 in Neurons and regulates Neuronal survival. , J. Exp Medicine (Cover). , 2007 , 204(9):2063-74.

11. Chenjian Li and M Flint Beal. , Leucine-rich repeat kinase 2: a New player with a familiar theme for Parkinson’s disease pathogenesis. , Proc Natl Acad Sci. USA. , 2005 , 102, 16535-16537.

12. Tsu-kang Sang, Chenjian Li, Lawrence Zipursky, George Jackson. , Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. , Hum Mol Genet. , 2005 , 14(3):357-72

13. Xiaofeng Gu, Chenjian Li, Weicheng Wei, Victor Lo, Shiaoching Gong, Shihua Li, TAkuji Iwasato, Shigeyoshi Itohara, XiaoJiang Li, Istvan Mody, Nathaniel Heintz, William Yang, , Pathological cell-cell interactions elicited by a neuropathogenic form of mutant huntingtin contribute to cortical pathogenesis in HD mice. , Neuron. , 2005 , 46, 433-444.

14. Chenjian Li, Wayne Brake, Russell Romeo, Marisa Gordon, Rodica Buzescu, Patrick Allen, Paul Greengard, Bruce McEwen , Hippocampal neuron dendritic spine maturation, synaptic proteins immunoreactivity and performance in spatial learning tasks in mice. , Proc Natl Acad Sci.USA. , 2004 , 101, 2185-90.

15. Shaoching Gong, William Yang, Chenjian Li, Nathaniel Heintz , Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kr Origin of Replication. , Genome Research. , 2002 , 12:1992-1998.

16. Bruce McEwen, Keith Akama, Steve Alves, Wayne Brake, Chenjian Li, Yuen G , Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. , Proc Natl Acad Sci USA. , 2001 , 98:7093-7100.

17. Milner, T. A., McEwen, B. S., Hayashi, S., Chenjian Li, Reagan, L. P., Alves, S. E. , Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. , J Comp Neurol. , 2001 , 429(3)355-371.

18. Chenjian Li, Chaoxian Geng, Hung-Tat Leung, Young Seok Hong, Lydia R. Strong, William L. Pak. , InaF, a Protein Required For Transient Receptor Potential Ca2+ Channel Function. , Proc Natl Acad Sci.USA. , 1999 , 96(23):13474-13479.

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