杨四海

南京大学生命科学学院教授

杨四海，南京大学生命科学学院教授、博士生导师；曾任生科院副院长（2015.1-2019.7）。

研究方向

主要从事分子遗传与进化、生物信息学研究方向：

(1)基因组遗传变异的分子机制;

(2)植物抗病基因的起源、遗传变异与保存机制、功能等;

(3)植物基因组学、植物功能基因组学;

获奖情况

第四批国家“万人计划”科技创新领军人才(中组部)

2018年度高校科学研究优秀成果奖自然科学一等奖

2017年科技部“创新人才推进计划”中青年科技创新领军人才 (科技部)

2015年入选江苏省“六大人才高峰”第十二批高层次人才支持计划

2014年入选南京大学第二批“登峰人才支持计划”

2013年江苏省教学成果奖(高等教育类)一等奖

2012年度教育部“新世纪优秀人才支持计划”

2010年度江苏省高校“青蓝工程”中青年学术带头人培养对象

科研成果

Yang S , Wang L, Huang J, Zhang X, Yuan Y,Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates highermutation rates in heterozygotes. Nature 523 :463-467 (IF5y=41.5)

Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WS*, Yang S* (2019) Large-scale identification and functional analysis of NLR genes in blast resistance in the Tetep rice genome sequence. PNAS 10.1073/pnas.1910229116 (IF5y=10.5)

Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M, Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J, Yang S* , Hurst LD* and Tian D* . (2019) The architecture of intra-organism mutation rate variation in plants. Plos Biol 17(4):e3000191 (IF5y=9.5)

Liu H, Huang J, Sun X, Li J, Hu Y, Yu L,Liti G, Tian D, Hurst LD*, Yang S*. (2018) Tetrad analysis in plants and fungifinds large differences in gene conversion rates but no GC bias. Nature Ecol Evol 2, 164–173 (IF=10.95)

Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Yu Sheng1 , Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S , Cheng T, Laux T, Gao Q, Peng Y, Liu N*, Yang S*, Shi J* (2018) Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation. Nature Plants 10.1038/s41477-018-0323-6 (IF=13.2)

Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li W-H* & Tian D*. (2018) Identifying a Large Number of High-Yield Genes in Rice by Pedigree Analysis, Whole-Genome Sequencing, and CRISPR-Cas9 Gene Knockout. PNAS 115(32): E7559-E7567

Liu H, Jia Y, Sun X, Tian D, Hurst LD*,Yang S*. (2017) Direct determination of the mutation rate in the bumblebeereveals evidence for weak recombination-associated mutation and an approximaterate constancy in insects. Mol Biol Evol 34: 119-130 (IF5y=14.5)

Liu H#, Zhang X#, Huang J, Chen JQ, Tian D,Hurst LD*, Yang S*. (2015) Causes and consequences of crossing-over evidencedvia a high-resolution recombinational landscape of the honey bee. Genome Biology 16:15(IF5y=18.5)

Chen X, Tian X, Xue L, Zhang X, Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice. Plant Physiol 180(4):2091-2105 (IF5y=7.3)

Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*, Yang S*. (2018) High resolution insight into recombination events at the SD1 locus in rice. Plant J DOI: 10.1111/tpj.14154

Gu L, Wu Y, Jiang M, Si W, Zhang X, TianD*, Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Riceat Early-Tillering Stage under Nutrient-Deficient and Nutrient-SufficientCondition. Plant Physiol 172: 1142-1153 (IF5y=7.367)

Xie Z, Wang L, Wang L, Wang Z, Lu, Z, TianD, Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progenysequencing of the perennial peach I. A low rate in woody perennials and ahigher mutagenicity in hybrids. P Roy Soc B-Biol Sci 283: 20161016.(IF5y=5.366)

Wang L, Zhang Y, Qing C, Tian D, Yang S*,Hurst LD.* Mutation rate analysis via parent-progeny sequencing of theperennial peach II: No evidence for recombination-associated mutation. P RoySoc B-Biol Sci 283: 20161785 (IF5y=5.366)

Si W, Yuan Y, Huang J, Zhang X, Zhang Y,Zhang Y, Tian D, Wang C, Yang YH*, Yang S*. (2015) Widely distributed hot andcold spots in meiotic recombination as shown by sequencing of rice F2 plants. New Phytologist 206 :1491-1502 (IF5y=7.84)

Zhang X#, Yang S#, Wang J#, Jia Y#, HuangJ#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*.(2015) A genome-wide survey reveals abundant rice blast R-genes in resistantcultivars. Plant J 84 :20-28 (IF5y =6.963)

Yang S#, Li J#, Zhang X#, Zhang Q, Huang J,Chen J-Q, Hartl DL*, Tian D*. (2013) Rapidly evolving R genes in diverse grassspecies confer resistance to rice blast disease. Proc Natl Acad Sci U S A 110:18572-18577. (IF5y=10.73)

Yang S#, Yuan Y#, Wang L#, Li J, Wang W,Liu H, Chen JQ, Hurst LD*, Tian D*. (2012) Great majority of recombinationevents in Arabidopsis are gene conversion events. Proc Natl Acad Sci U S A 109:20992–20997. (IF5y=10.73)

Yue J-X, Meyers BC, Chen J-Q, Tian D*, YangS*. (2012) Tracing the origin and evolutionary history of plantnucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063.(IF5y=7.84)

Tian D, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108

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