段恩奎

中国科学院动物研究所党委书记、副所长

段恩奎，博士，研究员，中国科学院动物研究所党委书记、副所长，973项目“人类生育调节及其相关重要疾病的基础研究”首席科学家，中国科学院“百人计划”优秀学者，兼任中国动物学会副理事长、国家人口与计生委科技专家委员会委员、中国科学院研究生院学位委员会委员、《动物学报》副主编、“Endocrine”，“Integrative Zoology”以及《科学通报》编委。

人物简介

中国科学院动物研究所党委书记

1990年在西北农业大学获博士学位，1995年-1996年和1998年，先后赴澳大利亚New England大学和美国Kansas大学医学中心从事动物生殖免疫和胚胎植入分子机理的合作研究。曾多次赴美、澳、加、德、日、希腊、蒙古国开展学术交流，4次应邀在国际会议上做报告。作为学术委员会副主席和会议共同主席参与主办了三次国际和双边学术会议。目前的主要研究方向为胚胎植入分子机理和干细胞生物学。主编（译）、参编专（译）著6部、在国内外发表论文105篇，其中SCI收录论文58篇，有2篇被Mol Hum Reprod和Hum Reprod作为封面文章，有1篇合作研究成果被Biol Reprod主编作为当期Highlight 加以介绍。获省、部级科技成果奖3项、国际会议优秀Poster奖2次，并获新世纪千百万人才工程国家级人选、国务院政府特殊津贴和国家重点实验室先进个人等荣誉称号和奖励。

研究领域

主要从事胚胎植入分子机理和干细胞生物学研究，目前正在以基因敲除鼠为模型开展胚胎植入和胚胎发育机制的相关研究，另一方面研究人和小鼠表皮发育与皮肤干细胞相关信号转导通路及调控

获奖荣誉

1992年 “陕西科协新秀”荣誉称号陕西省科协

1993年国务院政府特殊津贴国务院

1995年 “优秀中青年留学人员” 国家教委

1998年中科院“百人计划” 中国科学院

2000年辽宁省“科技进步二等奖”（主要完成人）辽宁省人民政府

2001年中科院“百人计划”优秀入选者中国科学院

2004年 “国家重点实验室先进个人”、科技部

2004年 “百千万人才工程国家级人选” 中组部、人事部等六部委

2006年 “全国人口与计划生育科技工作先进个人” 国家人口计生委

2007年上海市科技进步二等奖（主要完成人）上海市人民政府

2011年中国科学院朱李月华优秀教师奖中国科学院

2011年全国人口和计划生育优秀科技成果一等奖国家人口计生委

2011年第七届中华人口奖国家计划生育委员会

2015年全国妇幼健康科学技术一等奖国家妇幼健康研究会中国妇女发展基金会

科研项目

国家自然科学基金重大项目，胚胎着床过程中母-胎互作关键调控通路的生理和病理作用机制

代表论著

Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng G, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

Shi J, Chen Q, Li X, Zheng X, Zhang Y, Qiao J, Tang F, Tao Y*, Zhou Q*, and Duan E*. Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq.Development

Zhao Q, Liu S, Zhang H, Li N, Wang X, Cao Y, Ning L, Duan E*, and Xia G*. Spatiotemporal Expression of p63 in Mouse Epidermal Commitment. Int J Mol Sci

Zhang H, Zhang S, Zhao H, Qiao J, Liu S, Deng Z, Lei X, Ning L, Cao Y, Zhao Y, and Duan E*. Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin

Zhang S, and Duan E*. Epigenetic regulations on skin wound healing: implications from current researches. Ann Transl Med

Ning L, Lei X, Cao Y, Zhang Y, Cao Z, Chen Q, and Duan E*. Effect of Short-Term Hypergravity Treatment on Mouse 2-Cell Embryo Development. Microgravity Sci

Liu S, Wang X, Zhao Q, Liu S, Zhang H, Shi J, Li N, Lei X, Zhao H, Deng Z, Cao Y, Ning L, Xia G, Duan E*. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15 INK4b signaling

Deng Z, Lei X, Zhang X, Zhang H, Liu S, Chen Q, Hu H, Wang X, Ning L, Cao Y, Zhao T, Zhou J, Chen T, Duan E*. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration. J Mol Cell Biol

Zhao H, Qiao J, Zhang S, Zhang H, Lei X, Wang X, Deng Z, Ning L, Cao Y, Guo Y, Liu S, Duan E*. GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H, Ma T*, Qiao J*, Duan E*. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res

Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Res

Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, Zhang X, Duan E*. Rotary Suspension Culture Enhances Mesendoderm Differentiation of Embryonic Stem Cells Through Modulation of Wnt/β-catenin Pathway. Stem Cell Rev

Wang X, Liu S, Zhao Q, Li N, Zhang H, Zhang X, Lei X, Zhao H, Deng Z, Qiao J, Cao Y, Ning L，Liu S*, Duan E*. Three-dimensional hydrogel scaffolds facilitate in vitro self-renewal of human skin-derived precursors

Zhang Y, Zhang Y, Shi J, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen Z*, Chen Q*, Duan E*. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

Chen Q, Zhang Y, Elad D, Jaffa AJ, Cao Y, Ye X*, Duan E*. Navigating the site for embryo implantation: Biomechanical and molecular regulation of intrauterine embryo distribution

Liu S, Zhang H and Duan E* Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells. Int J Mol Sci

Cao Q, Chen H, Deng Z, Yue J, Chen Q, Cao Y, Ning L, Lei X, Duan E* Genetic deletion of Cxcl14 in mice alters uterine NK Cells, Biochem Biophys Res Commun

Zhang H, Zhang Y, Zhao H, Zhang Y, Chen Q, Peng H, Lei L, Qiao J, Shi J, Cao Z, Enkui Duan E*, Jin Y*Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins

Lu S, Peng H, Zhang H, Zhang L, Cao Q, Li R, Zhang Y*, Yang L*, Duan E, Qiao J. Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice

Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H. 2013 Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice

Zhang Q, Chen Q, Lu X, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y, Wang H. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface

Kong S, Zhang S, Chen Y, Wang W, Wang B, Chen Q, Duan E* & Wang H* Determinants of uterine aging: lessons from rodent models

Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q*,Duan E*A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm.Cell Res

Hu HM, Zhang SB, Lei XH, Deng ZL, Guo WX, Qiu ZF, Liu S, Wang XY, Zhang H, Duan EK* Estrogen Leads to Reversible Hair Cycle Retardation through Inducing Premature Catagen and Maintaining Telogen

Zhang S, Hu H, Zhang H, Liu S, Liu S, Zhang Y, Lei X, Ning L, Cao Y, Duan E*. Hair Follicle Stem Cells Derived from Single Rat Vibrissa via Organ Culture Reconstitute Hair Follicles in vivo. Cell Transplant

Liu S, Liu S, Wang X, Zhou J, Cao Y, Wang F, Duan E*. The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro. Aging Cell

Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK*. NASA-approved rotary bioreactor enhances proliferation of human epidermal stem cells and supports formation of 3D epidermis-like structure

Zhang Y, Zhao H, Peng H, Hu Z, Ning L, Cao Y, Tan Y, Duan E*. GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of the mouse prostate

Chen Q, Zhang Y, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E*. Transient β2-Adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. J Biol Chem

Chen Q, Duan EK*. Aquaporins in sperm osmoadaptation: an emerging role for volume regulation. Acta Pharmacol Sin

Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E*. Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration

Zhao P, Qiao J, Huang S, Zhang Y, Liu S, Yan LY, Hsueh AJ, Duan EK*.Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells

Peng H, Zhang Y, Lei L, Chen Q, Yue J, Tan Y*, Duan E*.2011 Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertil Steril

Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F*. Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions

Zhou J, Su P, Li D, Tsang S, Duan E, Wang F*. High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells

Li J, Kawamura K, Cheng Y, Liu S, Klein C, Liu S, Duan EK, Hsueh AJ*. Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A

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