沈前华

中科院遗传与发育生物学研究所研究员

2008年担任中科院遗传与发育生物学研究所研究员，博士生导师，入选中国科学院“BR计划”引进人才。1985年江西农大学士，1985-1987年华中农大植物遗传育种研究生，1999-2000年英国John Innes Centre硕士，2001-2004年德国马克斯-普朗克植物育种研究所（Max Planck Institute for Plant Breeding Research）博士，2004-2008年德国马普植物育种所博士后。

人物经历

2008-至今, 中国科学院遗传与发育生物学研究所，研究员，入选中国科学院“BR计划”海外引进人才

2004-2008 德国马普植物育种研究所(Max Planck Institute for Plant Breeding Research)，博士后

2001-2004 德国马普植物育种研究所和科隆大学(University of Cologne)，获博士学位

1999-2000 英国John Innes Centre和东安格利亚大学(University of East Anglia)，获硕士学位

1998-1999 英国西敏寺大学(University of Westminster)，国家留学基金委派出访问学者

1987-1998 于江西大学、南昌大学工作，历任助教、讲师、副教授

1985-1987 华中农业大学植物遗传育种专业，研究生

1981-1985 江西农业大学，获学士学位

研究方向

植物-病原菌分子互作，植物免疫机制

社会兼职

担任中国植物病理学会理事会常务理事；植物生理与分子生物学学会植物与微生物互作专业委员会副主任；

学术兼职

Phytopathology Research, Associate Editor；Frontiers of Agricultural Science and Engineering, Associate Editor; Frontier in Plant Science, Associate Editor。

研究领域

植物如何识别病原菌并激活抗病，病原菌如何巧妙地躲避识别或抑制寄主抗性，专性寄生真菌如何与植物建立寄生关系等等是重要的生物学前沿问题。作物抗病性也是重要的稳产性状，提高作物品种的抗病性可以减少农药使用、保护环境、绿色生产。实验室采用重要粮食作物大小麦与白粉菌分子互作的研究体系，采用遗传学、细胞生物学、生物化学和组学等研究手段研究作物抗病的分子机制，研究重要病原真菌的致病分子机理, 挖掘新型抗病基因，为抗病育种提供理论基础，并应用于创制抗病育种材料。

1、植物免疫受体的抗病机制

研究抗病蛋白的抗病机制，探索抗病基因在抗病育种中的应用。抗病蛋白或NLR免疫受体介导对病原菌专化性识别并诱导抗病免疫反应，我们研究这类抗病蛋白诱导抗病及细胞死亡的分子机制，以及抗病激活与转录重编程的关系，鉴定抗病蛋白复合体组份及下游信号组份，阐明抗病基因转录及翻译后的调控机制。

2、植物与病原真菌互作的跨界信号

病原真菌（如白粉菌）编码数百个效应蛋白，大多被分泌到寄主细胞中，通过干扰寄主的靶标蛋白功能抑制植物的抗病免疫反应增强病原菌致病性。植物和病原真菌的小分子RNA（主要是miRNA、siRNA）在植物与病原菌互作中也发挥重要的调控作用，并通过跨界调控靶标基因的表达起调控作用。通过研究效应蛋白的功能和作用机制，鉴定sRNA以及靶标基因及其调控机制，阐明跨界sRNA的作用机制。

3、麦类作物抗病遗传及抗病基因克隆

麦类作物真菌病害主要包括白粉病、锈病和赤霉病。我们研究大、小麦对病原真菌的抗病遗传，筛选抗病种质资源、挖掘抗病新位点，通过GWAS等技术鉴定和克隆新型抗病基因，包括广谱和专化性抗病基因。

代表论著

（#第一作者，*通讯作者）

1.Huaibing Jin#, Xinyun Han#, Zhaohui Wang#, Yilin Xie, Kunpu Zhang, Xiaoge Zhao, Lina Wang, Jin Yang, Huiyun Liu, Xiang Ji, Lingli Dong, Hongyuan Zheng, Weijuan Hu, Yan Liu, Xifeng Wang, Xueping Zhou, Yijing Zhang, Weiqiang Qian, Wenming Zheng, Qian-Hua Shen*, Mingyue Gou* and Daowen Wang*. Barley GRIK1-SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection. EMBO journal, e110521. (2022)

2.Deshui Yu, Renchun Fan, Ling Zhang, Pengya Xue, Libing Liao, Meizhen Hu, Yanjun Cheng, Jine Li, Ting Qi, Shaojuan Jing, Qiuyun Wang, Arvind Bhatt and Qian-Hua Shen*. HvWRKY2 acts as an immunity suppressor and targets HvCEBiP to regulate powdery mildew resistance in barley. Crop Journal, doi: 10.1016/j.cj.2022.05.010. (2022)

3.Xinmeng Gui, Peng Zhang, Dan Wang, Zhan Ding, Xian Wu, Jinxia Shi, Qian-Hua Shen, Yong-Zhen Xu, Wenbo Ma and Yongli Qiao. Phytophthora effector PSR1 hijacks the host pre-mRNA splicing machinery to modulate small RNA biogenesis and plant immunity. Plant Cell, 34: 3443-3459. (2022)

4.Baoyu Huai#, Pu Yuan#, Xiaoxuan Ma, Xiurui Zhang, Lihua Jiang, Peijing Zheng, Mohan Yao, Ziyu Chen, Liyang Chen, Qian-Hua Shen, Zhensheng Kang* and Jie Liu*. Sugar transporter TaSTP3 activation by TaWRKY19/61/82 enhances stripe rust susceptibility in wheat. New Phytologist, 236: 266-282. (2022)

5.Qiang Zhang#, Yinghui Li#, Yiwen Li, Tzion Fahima, Qian-Hua Shen* and Chaojie Xie*. Introgression of the Powdery Mildew Resistance Genes Pm60 and Pm60b from Triticum urartu to Common Wheat Using Durum as a ‘Bridge’. Pathogens, 11(1), 25. (2021)

6.Hongbo Yuan, Cong Jin, Hongcui Pei, Lifang Zhao, Xue Li, Jiali Li, Wanting Huang, Renchun Fan, Wende Liu and Qian-Hua Shen*. The Powdery Mildew Effector CSEP0027 Interacts with Barley Catalase to Regulate Host Immunity. Frontiers in Plant Science, doi: 10.3389/fpls.2021.733237. (2021)

7.Xue Li#, Cong Jin#, Hongbo Yuan#, Wanting Huang, Fang Liu, Renchun Fan, Jiankun Xie* and Qian-Hua Shen*. The barley powdery mildew effectors CSEP0139 and CSEP0182 suppress cell death and promote B. graminis fungal virulence in plants. Phytopathology Research, doi:10.1186/s42483-021-00084-z. (2021)

8.Xinyun Han#, Ling Zhang#, Lifang Zhao#, Pengya Xue, Ting Qi, Chunlei Zhang, Hongbo Yuan, Lixun Zhou, Daowen Wang, Jinlong Qiu and Qian-Hua Shen*. SnRK1 Phosphorylates and Destabilizes WRKY3 to Enhance Barley Immunity to Powdery Mildew. Plant Communications, 1(4):100083. (2020)

9.Fukai Zhao#, Yinghui Li#, Baoju Yang, Hongbo Yuan, Cong Jin, Lixun Zhou, Hongcui Pei, Lifang Zhao, Yiwen Li, Yilin Zhou, Jiankun Xie* and Qian-Hua Shen*. Powdery mildew disease resistance and marker-assisted screening at the Pm60 locus in wild diploid wheat Triticum urartu. Crop Journal, 8:252-259. (2020)

10. Huaibing Jin#, Zhiqiang Du#, Yanjing Zhang#, Judit Antal#, Zongliang Xia, Yan Wang, Yang Gao, Xiaoge Zhao, Xinyun Han, Yanjun Cheng, Qian-Hua Shen, Kunpu Zhang, Robert E. Elder, Zsigmond Benko, Csaba Fenyvuesvolgyi, Ge Li, Dionne Rebello, Jing Li, Shilai Bao, Richard Y. Zhao* and Daowen Wang*. A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. Science Advances, 6(20):eaba3418. (2020)

11. Tao Wang, Jiaxin Li and Qian-Hua Shen*. Regulation of NLR stability in plant immunity. Frontiers of Agricultural Science and Engineering, 6:97. (2019)

12. Jingjing Xing#, Xiaojuan Li#, Xiaohua Wang, Xueqin Lv, Li Wang, Liang Zhang, Yingfang Zhu, Qian-Hua Shen, Franti？ek Balu？ka, Jozef ？amaj and Jinxing Lin*. Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity. Plant Cell, 31(12):3015-3032. (2019)

13. Hongyuan Zheng#, Lingli Dong#, Xinyun Han, Huaibing Jin, Cuicui Yin, Yali Han, Bei Li, Huanju Qin, Jinsong Zhang, Qian-Hua Shen, Kunpu Zhang* and Daowen Wang*. The TuMYB46L-TuACO3 module regulates ethylene biosynthesis in einkorn wheat defense to powdery mildew. New Phytologist, 225:2526-2541. (2019)

14. Min Zhu#, Lei Jiang#, Baohui Bai, Wenyang Zhao, Xiaojiao Chen, Jia Li, Yong Liu, Zhengqiang Chen, Boting Wang, Chunli Wang, Qian Wu, Qian-Hua Shen, Savithramma P. Dinesh-Kumar, and Xiaorong Tao*. The Intracellular Immune Receptor Sw-5b Confers Broad-Spectrum Resistance to Tospoviruses through Recognition of a Conserved 21-Amino Acid Viral Effector Epitope. Plant Cell, 29(9):2214-2232. (2017)

15. Tao Wang, Cheng Chang, Cheng Gu, Sanyuan Tang, Qi Xie, and Qian-Hua Shen*. An E3 ligase affects the NLR receptor stability and immunity to powdery mildew. Plant Physiology, 172(4):2504-2515. (2016)

16. Yanfei Zhu, Yingbo Li, Fei Fei, Zongkuan Wang, Wei Wang, Aizhong Cao, Yuan Liu, Shuang Han, Liping Xing, Haiyan Wang, Wei Chen, Sanyuan Tang, Xiahe Huang, Qian-Hua Shen, Qi Xie, Xiue Wang*. E3 ubiquitin ligase gene CMPG1–V from Haynaldia villosa L. contributes to powdery mildew resistance in common wheat (Triticum aestivum L.). Plant Journal, 84(1):154-168. (2015)

17. Jie Liu, Xiliu Cheng, Da Liu, Weihui Xu, Roger Wise and Qian-Hua Shen*. The miR9863 Family Regulates Distinct Mla Alleles in Barley to Attenuate NLR Receptor-Triggered Disease Resistance and Cell-Death Signaling. PLoS Genetics, 10(12):e1004755. (2014)

18. Meng Li, Xiqing Ma, Yi-Hsuan Chiang, Koste A. Yadeta, Pengfei Ding, Liansai Dong, Yan Zhao, Xiuming Li, Yufei Yu, Ling Zhang, Qian-Hua Shen, Bin Xia, Gitta Coaker, Dong Liu*, and Jian-Min Zhou*. Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis. Cell Host & Microbe, 16(4):473-483. (2014)

19. Cheng Chang, Deshui Yu, Jian Jiao, Shaojuan Jing, Paul Schulze-Lefert, and Qian-Hua Shen*. Barley MLA Immune Receptors Directly Interfere with Antagonistically Acting Transcription Factors to Initiate Disease Resistance Signaling. Plant Cell, 25:1158-1173. (2013)

20. Cheng Chang, Ling Zhang and Qian-Hua Shen*. Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling. Frontiers in Plant Science, doi:10.3389/fpls.2013.00396. (2013)

21. Hong-Qing Ling#, Shancen Zhao#, Dongcheng Liu#, Junyi Wang#, Hua Sun#, Chi Zhang#, ..., Qian-Hua Shen, ..., Huanming Yang, Zhensheng Li, Daowen Wang, Aimin Zhang and Jun Wang. Draft genome of the wheat A-genome progenitor Triticum urartu. Nature, 496: 87-90. (2013)

22. Yumei Du#, Jinping Zhao#, Tianyuan Chen#, Qi Liu1, Haili Zhang, Yan Wang, Yiguo Hong, Fangming Xiao, Ling Zhang, Qian-Hua Shen and Yule Liu*. Type I J-Domain NbMIP1 Proteins Are Required for Both Tobacco Mosaic Virus Infection and Plant Innate Immunity. PLoS Pathogens, 9: e1003659. (2013)

23. Shiwei Bai, Jie Liu, Cheng Chang, Ling Zhang, Takaki Maekawa, Qiuyun Wang, Wenkai Xiao, Yule Liu, Jijie Chai, Frank L. W. Takken, Paul Schulze-Lefert and Qian-Hua Shen*. Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance. PLoS Pathogens, 8: e1002752. (2012)

24. Takaki Maekawa, Wei Cheng, Laurentiu N. Spiridon, Armin T？ller, Ewa Lukasik, Yusuke Saijo, Peiyuan Liu, Qian-Hua Shen, Marius A. Micluta, Imre E. Somssich, Frank L.W. Takken, Andrei-Jose Petrescu, Jijie Chai*, and Paul Schulze-Lefert*. Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death. Cell Host & Microbe, 9:187-199. (2011)

25. Guan-Feng Wang#, Xuening Wei#, Renchun Fan, Huanbin Zhou, Xianping Wang, Chunmei Yu, Lingli Dong, Zhenying Dong, Xiaojie Wang, Zhensheng Kang, Hongqing Ling, Qian-Hua Shen, Daowen Wang and Xiangqi Zhang*. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytologist, 191: 418-431. (2011)

26. Chunmei Yu, Yiwen Li, Bin Li, Xin Liu, Lifang Hao, Jing Chen, Weiqiang Qian, Shiming Li, Guanfeng Wang, Shiwei Bai, Hua Ye, Huanju Qin, Qian-Hua Shen, Liangbiao Chen, Aimin Zhang,Daowen Wang*. Molecular analysis of phosphomannomutase (PMM) genes reveals a unique PMM duplication event in diverse Triticeae species and the main PMM isozymes in bread wheat tissues. BMC Plant Biology, 10: 214. (2010)

27. Qian-Hua Shen, Yusuke Saijo, Stefan Mauch, Christoph Biskup, Stéphane Bieri, Beat Keller, Hikaru Seki, Bekir ülker, Imre E. Somssich, Paul Schulze-Lefert*. Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses. Science, 315:1098-1103. (2007)

28. Qian-Hua Shen, Paul Schulze-Lefert*. Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors. EMBO Journal., 26: 4293-4301. (2007)

29. Qian-Hua Shen, Yusuke Saijo, Stefan Mauch, Nico Tintor, Christoph Biskup, Bekir ülker, Imre E. Somssich, Silke Robatzek and Paul Schulze-Lefert*. Signal Integration in the Plant Immune. Book Chapter in: Biology of Molecular Plant-Microbe Interactions, Volume 6. Editors: Matteo Lorito, Sheri Woo and Felice Scala. (2007)

30. Stephane Bieri, Stefan Mauch, Qian-Hua Shen, Jack Peart, Alessandra Devoto, Catarina Casais, Francesca Ceron, Sabine Schulze, Hans-Henning Steinbi？, Ken Shirasu, and Paul Schulze-Lefert*. RAR1 Positively Controls Steady State Levels of Barley MLA Resistance Proteins and Enables Sufficient MLA6 Accumulation for Effective Resistance. Plant Cell, 16: 3480-3495. (2004)

31. P. Rodrigues, J. M. Garrood, Qian-Hua Shen, P. H. Smith and Lysley. A. Boyd*. The genetics of non-host disease resistance in wheat to barley yellow rust. Theor Appl Genet, 109: 425-432. (2004)

32. Qian-Hua Shen, Fasong Zhou, Stephane Bieri, Thomas Haizel, Ken Shirasu and Paul Schulze-Lefert*. Recognition Specificity and RAR1/SGT1 Dependence in Barley Mla Disease Resistance Genes to the Powdery Mildew Fungus. Plant Cell, 15: 732-744. (2003)

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