王钊

清华大学药学院教授博士生导师

王钊，汉族，清华大学药学院，教授，博士生导师。研究方向为分子细胞药理毒理学：中药的药理与毒理、神经药理、肿瘤药理、骨代谢与药物干预等；衰老机制及药物干预的研究：尤其是脑衰老及药物对神经退行性疾病等衰老相关疾病的研究；天然药物与功能保健品的研究与开发。

人物经历

1978-1983，河南中医学院医疗系，医学学士。

1984-1987，北京中医药大学基础医学院，医学硕士。

1990-1993，日本冈山大学药学院，药学硕士。

1993-1996，日本冈山大学药学院，药学博士。

1996-1998，日本冈山大学医学院，助理教授。

1998-，清华大学生命科学学院副教授、教授、校内双聘教授。

2004-，清华大学医学院教授。

2006-2007，美国纽约大学西奈山医学院，访问教授。

研究方向

分子细胞药理毒理学：中药的药理与毒理、神经药理、肿瘤药理、骨代谢与药物干预等；衰老机制及药物干预的研究：尤其是脑衰老及药物对神经退行性疾病等衰老相关疾病的研究；天然药物与功能保健品的研究与开发。《胎盘生物活性物质和质量控制的研究进展》于《中药材》2001年24卷11期发表等。

主要贡献

1·Jing Du, Junlei Chang, Songxi Guo, Qing Zhang, Zhao Wang*. ApoE4 Reduces the degrading enzyme IDE by Activating the NMDA Receptor inExpression of A Hippocampal Neurons. Neuroscience Letters. (2009) (in press)

2·Jing Du, Bing Sun, Kui Chen, Li Fan, Zhao Wang*. Antagonist of Peroxisome Proliferator-activated Receptor Induces Cerebellar Amyloid- Levels and Motor Dysfunction in APP/PS1 Transgenic Mice. Biochem Bioph Res Co. 384 (3): 357-361 (2009)

3·Zong-Chun Yi, Yan-Ze Liu, Hai-Xia Li, Zhao Wang*. Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H2O2/Cu(II), but potentiate DNA strand breaks by H2O2/Fe(II). Toxicology in Vitro. 23 (4) 667–673 (2009)

4·Jing Du, Bing Sun, Kui Chen, Lang Zhang, Shubo Liu, Qingquan Gu, Li Fan, Nanming Zhao, Zhao Wang*. Metabolites of Neurons Play Essential Role in Pathogenesis of Alzheimer's Disease. PLoS ONE. 4 (5): e5530 (2009)

5·Jing Du, Lang Zhang, Shubo Liu, Chi Zhang, Xiuqing Huang, Jian Li, Nanming Transcriptionally Regulates the Expression ofZhao, Zhao Wang*. PPAR Insulindegrading Enzyme in Primary Neurons. Biochem Bioph Res Co. 383 (4): 485-490 (2009) ·

6·Min Fu, Ruxin Li, Li Fan, Guowei He, Kent L Thornburg, Zhao Wang*: Sarcoplasmic Reticulum Ca2+ Release Channel Ryanodine Receptor (RyR2) Plays a Crucial Role in Aconitine-induced Arrhythmias. Biochemical Pharmacology. 75 (11) 2147-2156 (2008)

7·Mingchao XIE, Chao AI, Shangfeng LIU, Shixin TAO, Zhao WANG*Cloning and characterization of chicken SPATA4 gene and analysis of its specific expression. Molecular and Cellular Biochemistry. 306 (1-2): 79-85 (2007)

8·Min Fu, Meng Wu, Jifeng Wang, Yanjiang Qiao, Zhao Wang*: Disruption of the Intracellular Ca2+ Homeostasis in the Cardiac Excitation-Contraction Coupling is a Crucial Mechanism of Arrhythmic Toxicity in Aconitine-induced Cardiomyocytes. Biochem Bioph Res Co. 354 (4): 929-936 (2007)

9·Liu Hai-Luo, Liu Shang-Feng, Ge Ye-Jing, Liu Jing, Wang Xiao-Yan, Xie Li-Ping, Zhang Rong-Qing, Wang Zhao*: Identification and characterization of a biomineralization related gene PFMG1 highly expressed in the mantle of pinctada fucata. Biochemistry. 46 (3): 844-851 (2007)

10·Zong-Chun Yi, Zhao WANG*, Hai-Xia Li, Yan Yin, Feng-Yuan Zhuang, and Yu-Bo Fan: Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Letters. 242 (1)77-87 (2006)

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