董磊

南京大学生命科学学院教授

学术兼职

中国细胞生物学会第一届青年委员会委员, 中国生物材料学会会员, 中国药学会高级会员, ACS Nano, Biomaterials, Pharmaceutical Research, Biochemical Pharmacology, Advanced Drug Delivery Review, Journal of Material Research, Molecular Pharmaceutics 等期刊的审稿人。

研究方向

主要从事生物材料与生物系统的相互作用研究，目前的研究重点是纳米物质与细胞的相互作用界面。研究内容是纳米物质与生理环境中细胞的相互作用方式及原理，Protein corona 介导的纳米物质/细胞表面生物大分子相互作用，增强/增加细胞对环境因素响应能力的新型纳米生物技术，以及纳米材料与生物系统相互作用研究中的新方法和新技术。以上研究有助于理解环境中的纳米物质对人体生物系统的影响，并为未来先进材料与生物系统的深度融合提供新的技术和理论。在此基础之上，课题组还进行智能纳米药物递送系统，组织修复、重构及工程化，以及炎症相关疾病的转化医学研究等方向上的探索。

科研成果

代表性论文：

1.Zhengping Zhang; Chunming Wang; Yinhe Zha; Wei Hu; Zhongfei Gao; Yuhui Zang; Jiangning Chen; Junfeng Zhang; *Lei Dong. Corona-Directed Nucleic Acid Delivery into Hepatic Stellate Cells for Liver Fibrosis Therapy. ACS Nano, 2015 Mar 24;9(3):2405-19.

2.Zhou Zhen; Li Xihan; Liu Jinxiong; Dong Lei; Chen Qun; Liu Jialing; Kong Huihui; Zhang Qianyi; Qi Xian; Hou Dongxia; Zhang Lin; Zhang Guoquan; Liu Yuchen; Zhang Yujing. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Research, 2015 Jan;25(1):39-49. (Co-first Author)

3.Huang Zhen; Gan Jingjing; Jia Lixin; Guo Guangxing; Wang Chunming; Zang Yuhui; Ding Zhi; Chen Jiangning; Zhang Junfeng; *Dong Lei. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials, 2015 Apr;48:26-36.

4.Chunming Wang; *Lei Dong. Exploring 'new' bioactivities of polymers at the nano-bio interface. Trends in Biotechnology, 2015 Jan;33(1):10-4.

5.Zhan Xiudan; Jia Lixin; Niu Yiming; Qi Haixia; Chen Xiuping; Zhang Qingwen; Zhang Junfeng; Wang Yitao; *Dong Lei; Wang Chunming. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 2014 Dec;35(38):10046-57.

6.Qian Zhu; Lixin Jia; Zhongfei Gao; Chunming Wang; Haoyang Jiang; Junfeng Zhang; *Lei Dong. A tumor environment responsive doxorubicin-loaded nanoparticle for targeted cancer therapy. Molecular Pharmaceutics, 2014 Oct 6;11(10):3269-78.

7.Zhen Huang; Zhenzhen Wang; Shanshan Long; Haoyang Jiang; Jiangning Chen; Junfeng Zhang; *Lei Dong. A 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System. Molecular Pharmaceutics. Mol Pharm. 2014 Jul 7;11(7):2051-61.

8.Zhengping Zhang; Yinhe Zha; Wei Hu; Zhen Huang; Zhongfei Gao; Yuhui Zang; Jiangning Chen; *Lei Dong; Junfeng Zhang. The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development. Journal of Biological Chemistry, 2013 Dec 27;288(52):37082-93.

9.Zhengwei Yao; Wei Hu; Shan Yin; Zhen Huang; Qian Zhu; Jiangning Chen; Yuhui Zang; *Lei Dong; Junfeng Zhang. 3,3'-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway. Pharmacological Research, 2013 Apr;70(1):139-46.

10.Zhengping Zhang; Zhongfei Gao; Wei Hu; Shan Yin; Chunming Wang; Yuhui Zang; Jiangning Chen; Junfeng Zhang; *Lei Dong. 3,3 '-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. British Journal of Pharmacology, 2013 Oct;170(3):649-60.

11.Lei Dong; Chunming Wang. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology, 2013 Jun;31(6):342-6.

12.Rui Wang; Zhenheng Wang; Yutao Ma; Guoyin Liu; Hao Shi; Jiangning Chen; *Lei Dong; Jianning Zhao; Junfeng Zhang. Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening. Biomaterials, 2013 Apr;34(11):2611-23.

13.Huang Zhen; Jiang Yucui; Yang Yang; Shao Juan; Sun Xulun; Chen Jiangning; *Dong Lei; *Zhang Junfeng. 3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction. Molecular Immunology, 2013 Apr;53(4):335-44.

14.Zhen Huang; Yang Yang; Yucui Jiang; Juan Shao; Xulun Sun; Jiangning Chen; *Lei Dong; Junfeng Zhang. Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers. Biomaterials, 2013 Jan;34(3):746-55.

15.Zhen Huang; Zhengping Zhang; Yucui Jiang; Dachuan Zhang; Jiangning Chen; *Lei Dong; Junfeng Zhang. Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy. Journal of Controlled Release, 2012 Mar 10;158(2):286-92.

16.Zhen Huang; Zhengping Zhang; Yinhe Zha; Jialin Liu; Yucui Jiang; Yang Yang; Juan Shao; Xulun Sun; Xin Cai; Yuan Yin; Jiangning Chen; *Lei Dong; Junfeng Zhang. The effect of targeted delivery of anti-TNF-alpha oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice. Biomaterials, 2012 Oct;33(30):7605-12.

17.Lei Dong; Zhen Huang; Xing Cai; Jiawei Xiang; Yi-An Zhu; Rui Wang; Jiangning Chen; *Junfeng Zhang. Localized delivery of antisense oligonucleotides by cationic hydrogel suppresses TNF-alpha expression and endotoxin-induced osteolysis. Pharmaceutical Research, 2011 Jun;28(6):1349-56.

18.Huan Chen; Pei Li; Yuan Yin; Xing Cai; Zhen Huang; Jiangning Chen; *Lei Dong; Junfeng Zhang. The promotion of type 1 T helper cell responses to cationic polymers in vivo via toll-like receptor-4 mediated IL-12 secretion. Biomaterials, 2010 Nov;31(32):8172-80.

19.Lei Dong; Suhua Xia; Ke Wu; Zhen Huang; Huan Chen; Jiangning Chen; Junfeng Zhang. A pH/enzyme-responsive tumor-specific delivery system for doxorubicin. Biomaterials, 2010 Aug;31(24):6309-16.

20.Zhen Huang; Longsheng Zuo; Zhengping Zhang; Jialin Liu; Jiangning Chen; *Lei Dong; Junfeng Zhang. 3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway. Free Radical Biology and Medicine, 2011 Jan 15;50(2):228-36.

21.Lei Dong; Suhua Xia; Huan Chen; Jiangning Chen; Junfeng Zhang. Anti-arthritis activity of cationic materials. Journal of Cellular and Molecular Medicine, 2010 Jul;14(7):2015-24.

22.Lei Dong; Suhua Xia; Fengbo Gao; Dachuan Zhang; Jiangning Chen; Junfeng Zhang. 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis. Biochemical Pharmacology, 2010 Mar 1;79(5):715-21.

23.Dong Lei; Zuo, Longsheng; Xia, Suhua; Gao, Shuying; Zhang, Chenyu; Chen, Jiangning; *Zhang, Junfeng. Reduction of liver tumor necrosis factor-alpha expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis. Journal of Gene Medicine, 2009 Mar;11(3):229-39.

24.Dong Lei; Wang, Rui; Zhu, Yi-An; Wang, Chunming; Diao, Huajia; Zhang, Chenyu; Zhao, Jianning; *Zhang, Junfeng. Antisense oligonucleotide targeting TNF-alpha can suppress Co-Cr-Mo particle-induced osteolysis. Journal of Orthopaedic Research, 2008 Aug;26(8):1114-20.

25.Dong Lei; Gao, Shuying; Diao, Huajia; Chen, Jiangning; *Zhang, Junfeng. Galactosylated low molecular weight chitosan as a carrier delivering oligonucleotides to Kupffer cells instead of hepatocytes in vivo. Journal of Biomedical Materials Research Part A, 2008 Mar 1;84(3):777-84.

26.Dong Lei; Cheng, Ni; Wang, Ming-Wei; Zhang, Junfeng; Shu, Chang; *Zhu, De-Xu. The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme. Microbiology-SGM, 2005 Jun;151(Pt 6):2017-23.

27.Dong Lei; Xia, Suhua; Chen, Huan; Chen, Jiangning; *Zhang, Junfeng. Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models. Biomaterials, 2009 Sep;30(26):4416-26.

28.Dong Lei; Xia, Suhua; Luo, Yi; Diao, Huajia; Zhang, Jiani; Chen, Jiangning; *Zhang, Junfeng. Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-alpha. Journal of Controlled Release, 2009 Mar 19;134(3):214-20.

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