计剑

浙江大学教授

计剑，男，浙江大学教授，博士生导师。1992年毕业于浙江大学化学系并获得学士学位，1997年获高分子化学与物理博士学位，2004年晋升教授，2008年任浙江大学生物医用大分子研究所副所长。

获奖及荣誉

2000年第六届世界生物材料大会杰出博士后旅行奖。

2002年第十七届欧洲生物材料大会优秀青年科学家奖

2004年国家教育部霍英东基金优选资助项目

2005年国家教育部“新世纪优秀人才支持计划”

2010年获国家杰出青年科学基金资助

2024年当选2024国际生物材料科学与工程学会联合会“生物材料科学与工程Fellow”

研究领域

主要从事生物医用材料的应用基础研究，在生命体系与材料界面的生物相容性和生物功能性方面开展了系统深入的研究，形成了采用过程仿生的自组装行为制备具有结构和功能仿生的新型生物材料的研究特色，并将该原理应用到现代介入医用材料和组织工程材料的设计和研发中。

（1）心血管医用材料和微创介入医用材料

（2）医用材料的组织工程化设计

（3）生物治疗用智能纳米微载体

（4）新型固相基因传递体系的研究

（5）仿生双亲聚合物的溶液和界面组装

（6）层层组装构建生物相容性和生物功能性纳米层状超薄膜的研究

英文介绍

Dr. Jijian received a bachelor’s degree at Chemistry Department of Zhejiang University in 1992. He joined the department in 1997 after getting his PhD degree in the Institute of Polymer composites of Zhejiang University in 1997, and became an associated professor and full professor in 2000 and 2004, respectively. He teaches two undergraduate courses related to the polymeric composite and functional polymer and one Ph. D course related to polymer surface and interface. He has been doing research work in the polymeric biomaterials and biological interface for over 10 years and has published more than 50 research papers in peer reviewed international Journal.

His main research interest focuses on polymeric biomaterials and biological interface. Based on the biomimic strategy, several supramolecular self-assemble methods were explored to develop biocompatible and biofunctional materials. Electrostatic self –assembly” method, which based on the alternating physisorption of oppositely charged polyelectrolytes, was explored to develop several functional multilayer coating onto biomaterial to represent the desirable properties, such as anti-coagulation, promote cytocompatibility and control release of DNA. In following the biological perspective of glycocalyx, the poly(ethylene oxide) comb-like copolymers were explored to engineer glycocalyx-mimic surfaces, which reduce the non-specific interaction and end-tethered ligand to trigger biomolecules self-assemble. Get inspiration of the cell membrane structure, a kind of cell membrane biomimetic micelles were developed via supramolecular aggregation of a biomimetic amphiphilies. The biomimetic nano-carriers show low toxicity and high cell uptake ratio, which might be suitable as a carrier vehicle for delivering bioactive agents.

代表性论文

在包括Advanced Materials, Biomaterials, Langmuir等核心期刊发表SCI, EI收录论文90余篇，影响因子大于6.0的10篇，大于3.0的36篇，获国家发明专利12项。是我国具有自主知识产权的心动系列细胞膜仿生药物涂层支架的主要发明人。

Quankui Lin , Xin Ding , Fuyu Qiu , Xiaoxiao Song , Guosheng Fu , Jian Ji*, In situ endothelialization of intravascular stents coated with an anti-CD34 antibody functionalized heparin–collagen multilayer, Biomaterials, 2010,31, 4017-4025 (2010 IF: 7.882)

2. Lan Jia, Jian-Ping Xu,* Di Li, Shao-Peng Pang, Yuan Fang, Zhe-Gang Song, Jian Ji*, Fluorescence detection of alkaline phosphatase activity with β-cyclodextrin-modified quantum dots, Chem. Commun., 46,7166-7168 (2010 IF: 5.787)

3. Wenbo Zhou, Jinyan Shao, Qiao Jin, Qingshan Wei, Jianguo Tang, Jian Ji*, Zwitterionic phosphorylcholine as a better ligand for gold nanorods cell uptake and selective photothermal ablation of cancer cells, Chem. Commun., 2010, 46, 1479-1481 (2010 IF: 5.787)

4. Gongyan Liu, Qiao Jin, Xiangsheng Liu, Liping Lv, Chaojian Chen, Jian Ji*， Biocompatible Vesicles Based on PEO-b-PMPC/α-Cyclodextrin Inclusion Complexes for Drug Delivery. Soft Matter, in press, (2010 IF: 4.457)

5. Fang-Ming Xu, Jian-Ping Xu*, Li-Ping Lv and Jian Ji*， Bowl- and porous sphere-shaped supramolecular assemblies and their application as templates for confined assembly of gold nanoparticles, Soft Matter, in press, (2010 IF: 4.457)

6. Leize Zhu, Yonggang Shangguan, Yixin Sun, Jian Ji*, Qiang Zheng, Rheological properties of redox-responsive, associative ferrocene-modiﬁed branched poly(ethylene imine) and its modulation by β-cyclodextrin and hydrogen peroxide, Soft Matter, 2010, 6, 5541-5546 (2010 IF: 4.457)

7. Qiao Jin, Gongyan Liu, Xiangsheng Liu, Jian Ji*, Photo-responsive supramolecular self-assembly and disassembly of an azobenzene-containing block copolymer, Soft Matter, 2010, 6, 5589-5595 (2010 IF: 4.457)

8. Jianping Xu, Xi Yang, Liping Lv, Yu Wei, Fangmin Xu, Jian Ji*, Gold Nanoparticles Stabilized Pluronic Micelles Exhibiting Glutathione Triggered Morphology Evolution Properties, Langmuir, 2010, DOI: 10.1021/la102929k. (2010 IF: 4.268)

9. Liyan Shen, Jinhong Fu, Ke Fu, Catherine Picart, Jian Ji*, Humidity Responsive Asymmetric Free-Standing Multilayered Film, Langmuir, 2010, DOI: 10.1021/la102928g (2010 IF: 4.268)

10. Wei Sun, Liyan Shen, Jiaming Wang, Ke Fu, Jian Ji*, Netlike Knitting of Polyelectrolyte Multilayers on Honeycomb-Patterned Substrate, Langmuir, 2010, 26(17),14236–14240 (2010 IF: 4.268)

11. Xiaofen Hu, Jian Ji*, Construction of Multifunctional Coatings via Layer-by-Layer Assembly of Sulfonated Hyperbranched Polyether and Chitosan, Langmuir, 2010, 26 (4), 2624-2629 (2010 IF: 4.268)

12. Qiao Jin, Gongyan Liu, Jian Ji*, Micelles and Reverse Micelles with a Photo and ThermoDouble-Responsive Block Copolymer, J. Polym. Sci.: Part A: Polym. Chem., 2010, 48, 2855–2861 (2010 IF: 3.894)

13. Jinhong Fu, Jian Ji*, Liyan Shen, Alexander Ku¨ller, Axe Rosenhahn, Jiacong Shen, and Michae Grunze*,pH-Amplified Exponential Growth Multilayers: A Facile Method to Develop Hierarchical Micro- and Nanostructured Surfaces, Langmuir, 2009, 25 (2), 672-675 (2010 IF: 4.268)

14. Xuefei Wang and Jian Ji*, Postdiffusion of Oligo-Peptide within Exponential Growth Multilayer Films for Localized Peptide Delivery, Langmuir, 2009, 25(19), 11664–11671 (2010 IF: 4.268)

15. 孙婕衎, 王雪飞, 计剑*, 层状组装：先进药物控释涂层材料的新选择, 化学进展, 2009, 21, 2682-2688. (2010 IF: 0.56)

16. Qiao Jin, Jianping Xu, Jian Ji*, Jiacong Shen, Zwitterionic phosphorylcholine as a better ligand for stabilizing large biocompatible gold nanoparticles, Chem. Commun., 2008: 3058-3060 (2010 IF: 5.787)

17. Qingshan Wei, Jian Ji*, Jiacong Shen, Synthesis of near-infrared responsive gold nanorod/PNIPAAm core/shell nanohybrids via surface initiated ATRP for smart drug delivery, Macromol. Rapid Commun., 2008, 29: 645-650 (2010 IF: 4.365)

18. Wei Sun, Jian Ji*, Jiacong Shen, Rings of Nanoparticle-Decorated Honeycomb-Structured Polymeric Film: The Combination of Pickering Emulsions and Capillary Flow in the Breath Figures Method, Langmuir, 2008, 24: 11338-11341 (2010 IF: 4.268)

19. Liyan Shen, Jian Ji*, Jiacong Shen, Silver mirror reaction as an approach to construct superhydrophobic surfaces with high reflectivity, Langmuir, 2008, 24: 9962-9965 (2010 IF: 4.268)

20. Xiaolin Li, Jian Ji*, XiaoliWang , Youxiang Wang, Jiacong Shen, Stability and Drug Loading of the Spontaneous Vesicles of Comb-like PEG Derivates, Macromol. Rapid Commun., 2007, 28 (5): 660-665 (2010 IF: 4.365)

21. Ji Jian, Fu Jin-Hong, Shen Jia-Cong, Fabrication of a Superhydrophobic Surface from the Amplified Exponential Growth of a Multilayer, Adv. Mater., 2006, 18: 1441-1444 (2010 IF: 10.857)

22. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Construction and enzymatic degradation of multilayered poly-l-lysine/DNA films, Biomaterials, 2006, 27(7): 1152-1159 (2010 IF: 7.882)

23. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Tunable DNA release from cross-linked ultrathin DNA/PLL multilayered films, Bioconj. Chem.,2006, 17 (1): 77-83 (2010 IF: 5.002)

24. Li Xiao-Lin, Ji Jian*, Shen Jia-Cong, Spontaneous vesicle formation in aqueous solutions of comb-like PEG, Macromol. Rapid Commun., 2006, 27 (3): 214-218 (2010 IF: 4.365)

25. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Construction of Polycation-based non-viral DNA Nanoparticles and Polyanion Multilayers via Layer-by-layer Self-assembly. Macromol. Rapid Commun., 2005, 26, 1633-1638 (2010 IF: 4.365)

26. Fu Jin-Hong, Ji Jian*, Shen Jia-Cong, Construction of Anti-adhesive and Antibacterial Multilayer Films Via Layer-by-layer Assembly of Heparin and Chitosan, Biomaterials, 2005, 26 (33): 6684-6692 (2010 IF: 7.882)

27. XuJian-Ping, Ji Jian*, Chen Wei-Dong , Shen Jia-Cong, Novel biomimetic polymersomes as polymer therapeutics for drug delivery, J. Control. Release, 2005, 107( 3): 502-512 (2010 IF: 7.164)

28. Ji Jian*, Zhu Hui-Guang, Shen Jia-Cong, Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth, Biomaterials, 2004, 25 (10): 1859-1867 (2010 IF: 7.882)

29. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, Biomacromolecules Electrostatic Self-assembly on 3-Dimensional Tissue Engineering Scaffold, Biomacromolecules, 2004, 5(5):1933-1939 (2010 IF: 5.325)

30. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, Construction of multilayer coating onto poly-(dl-lactide) to promote cytocompatibility, Biomaterials, 2004, 25:109-117 (2010 IF: 7.882)

31. Ji Jian*, Feng Lin-Xian, Shen Jia-Cong, ‘Loop’ or ‘Tail’? Self-assembly and Surface Architecture of Polystyrene-graft-w-stearyl-poly(ethylene oxide), Langmuir, 2003, 19, 2643-2648 (2010 IF: 4.268)

32. Tang Qing-Ging, Ji Jian*, Barbosa MA, Fonseca C., Shen Jia-Cong, Construction thromboresistant surface on biomedical stainless steel via layer-by-layer deposition antocoagulant, Biomaterials, 2003, 24, 4699-4705 (2010 IF: 7.882)

33. Zhu Hui-Guang, Ji Jian*, Tan Qing-Guang, M. A. Barbosa, Shen Jia-Cong, Surface Engineering of Poly (DL-lactide) via Electrostatic Self-assembly of Extracellular Matrix-like Molecules, Biomacromolecules, 2003, 4: 378-386 (2010 IF: 5.325)

34. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, surface engineering of poly (DL-lactic acid) by entrapment of biomacromolecules, Macromol. Rapid Commun., 2002, 23, 819-823 (2010 IF: 4.365)

35. Zhu Hui-Guang, Ji Jian*, Lin Rong-Yi, Gao Chang-You, Feng Lin-Xian, Shen Jia-Cong, Surface engineering of poly(DL-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis, Biomaterials, 2002, 23 (15): 3141-3148 (2010 IF: 7.882)

36. Ji Jian*, Feng Lin-Xian, M. A. Barbosa, Stearyl poly(ethylene oxide) grafted surfaces as albumin preferential material, Biomaterials, 2001, 22(22): 3015-23 (2010 IF: 7.882)

37. Ji Jian*, Feng Lin-Xian, Qiu Yong-Xin, Yu Xiao-Jie, Stearyl poly(ethylene oxide) grafted surface as an albumin preferential materials 2 The effect of the molecule mobility onto protein adsorption, Polymer, 2000, 41, 3713-3718 (2010 IF: 3.828)

38. Ji Jian*, Feng Lin-Xian, Qiu Yong-Xin, Yu Xiao-Jie, ESR Spectroscopy as a probe of the molecular mobility of poly(ethylene oxide) amphiphilic graft copolymer Macromol. Rapid Commun., 1998, 19, 473-477 (2010 IF: 4.365)

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