陈国胜

中山大学化学学院副教授、博士生导师

陈国胜，性别：男，出生年月：1990-05，籍贯：广东，现为中山大学化学学院副教授、博士生导师。

人物经历

教育经历

2013.09-2018.06：中山大学物理化学专业，博士（导师：欧阳钢锋教授）

2009.09-2013.06：中山大学应用化学专业，学士

工作经历

2021.02- 中山大学化学学院，副教授

2018.12-2020.12：中山大学化学学院，博士后

科研方向

面向分析测量和环境污染控制的新型功能材料的基础及应用研究，包括酶-多孔晶态杂化框架设计、生物传感及标志物分析新方法和环境催化新技术等方面的研究工作，以第一/通讯作者身份在Nat. Protoc.、Sci. Adv.、Nat. Commun.、Chem、JACS、Angew. Chem.、Matter、CCS Chem等期刊发表SCI论文45篇。

科研项目

主持的部分科研项目：

1. 中组部青年拔尖人才（2024-12至2027-11，项目负责人）

2. 广东省自然科学基金杰出青年基金项目（2024-01至2027-12，项目负责人）

3. 国家自然科学基金面上项目（2022-01至2025-12，项目负责人）

4. 国家自然科学基金青年项目（2020-01至2022-12，项目负责人）

5. 中国博士后创新人才支持计划（2019-09至2021-08，项目负责人）

6. 中国博士后基金面上项目（2019-05至2021-05，项目负责人）

7. 广东省自然科学基金面上项目（2019-10至2022-09，项目负责人）

8. 中山大学青年拔尖人才计划（2023-01至2024-12，项目负责人）

9. 中山大学青年教师培育项目（2019-01至2021-12，项目负责人）

奖励情况

1. 入选国家级高层次青年人才

2. 广东省杰出青年基金

3. 2022年中国分析测试协会科学技术奖CAIA奖特等奖（第二完成人）

4. 入选由英国分析化学家网评选的2022年度全球40位40岁以下精英分析化学家名单

5. 入选博新人才支持计划

6. “微瑞杯”第二届全国大学生化学实验创新设计竞赛总决赛特等奖（指导老师）

7. 入选2023和2024年度全球前2%顶尖科学家榜单

代表性论文

(1) Huang, Siming; Chen, Guosheng*; Ouyang, Gangfeng*. Confiningenzymes in porous organicframeworks: from synthetic strategy andcharacterization to healthcareapplications. Chem. Soc. Rev. 2022, 51,6824-6863 (ESI highly cited paper).

(2) Chen, Guosheng*; Huang, Siming; Ma, Xiaomin; He, Rongwei;Ouyang, Gangfeng*. Encapsulating and stabilizing enzymes using hydrogen-bondedorganic frameworks. Nat. Protoc. 2023, 18, 2032–2050 (ESI highly citedpaper).

(3) Tong, Linjing; Huang, Siming; Shen, Yujian; Liu, Suya; Ma, Xiaomin;Zhu, Fang; Chen, Guosheng*; Ouyang, Gangfeng. Atomically unveiling thestructure-activity relationship of biomacromolecule-metal-organic frameworkssymbiotic crystal. Nat. Commun. 2022, 13, 951 (ESI highly cited paper).

(4) Chen, Guosheng*; Tong, Linjing; Huang, Siming; Huang, Shuyao;Zhu, Fang; Ouyang, Gangfeng*. Hydrogen-bonded organic framework biomimeticentrapment allowing non-native biocatalytic activity in enzyme. Nat. Commun.2022, 13, 4816 (Featured Article in chemical biology).

(5) Huang, Wei; Yuan, Haitao; Yang, Huangsheng; Ma, Xiaomin; Huang,Shuyao; Zhang, Hongjie; Huang, Siming; Chen, Guosheng*; and Ouyang,Gangfeng*. Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded,π-π-stacking supramolecular assembly for electrochemical immunosensor. Nat.Commun.2023, 14, 3644 (Featured Article in chemical biology).

(6) Jiang, Ruifen#; Luo, Gan#; Chen, Guosheng*; Lin, Yuhong; Tong,Linjing; Huang, Anlian; Zheng, Yang; Shen, Yong*; Huang, Siming; Ouyang,Gangfeng*. Boosting the photocatalytic decontamination efficiency using asupramolecular photo-enzyme ensemble. Science Advances, 2024,10, eadp1796.

(7) Tong, Linjing; Gong, Zeyu; Wang, Yidong; Luo, Jiaxuan; Huang,Siming; Gao, Rui; Chen, Guosheng*; Ouyang, Gangfeng. Atomically PreciseRegulation of the N-Heterocyclic Microenvironment in Triazine Covalent OrganicFrameworks for Coenzyme Photocatalytic Regeneration. J. Am. Chem. Soc.2024, 146, 21025-21033.

(8) Guo, Lihong, He, Rongwei, Chen, Guosheng*, Yang,Huangsheng, Kou, Xiaoxue, Huang, Wei, Gao, Rui*, Huang, Shuyao*, Huang,Siming*, Zhu, Fang, Ouyang, Gangfeng*. A Synergetic Pore Compartmentalizationand Hydrophobization Strategy for Synchronously Boosting the Stability andActivity of Enzyme. J. Am. Chem. Soc. 2024, 146, 17189-17200.

(9) Huang, Siming*; Li, Jiansheng; Lin, Yuhong; Tong, Linjing; Zhong,Ningyi; Huang, Anlian; Ma, Xiaomin; Huang, Shuyao; Yi, Wei; Shen, Yong*; Chen,Guosheng*; Ouyang, Gangfeng*. Hydrogen-bonded supramolecular nanotrapenabling the interfacial activation of hosted enzyme. J. Am. Chem. Soc. 2024,146, 3, 1967–1976 (Selected as Cover Paper).

(10) Chen, Guosheng#; Huang, Siming#; Shen, Yong; Kou, Xiaoxue; Ma,Xiaomin; Huang, Shuyao; Tong, Qing; Ma, Kaili; Chen, Wen; Wang, Peiyi; Shen,Jun; Zhu,Fang; Ouyang, Gangfeng*. Proteins-directed, hydrogen-bonded biohybrid framework.Chem 2021, 7, 2722-2742.

(11) Gao, Rui+; Kou, Xiaoxue+; Tong, Linjing; Li, Zhi-Wei; Shen,Yujian; He, Rongwei; Guo, Lihong; Wang, Hao; Ma, Xiaomin; Huang, Siming; Chen,Guosheng*; and Ouyang, Gangfeng. Ionic Liquid-Mediated DynamicPolymerization for Facile Aqueous-Phase Synthesis of Enzyme-Covalent OrganicFramework Biocatalysts. Angew. Chem. Int. Ed. 2024, e202319876.

(12) Tong, Linjing; Lin, Yuhong; Kou, Xiaoxue; Shen, Yujian;Shen, Yong*;Huang, Siming*; Zhu, Fang; Chen, Guosheng*; Ouyang, Gangfeng.Pore-Environment-Dependent Photoresponsive Oxidase-like Activity inHydrogen-Bonded Organic Frameworks. Angew. Chem.Int. Ed. 2023, 62,e202218661(VIP paper).

(13) Tang, Zhuopeng#; Li, Xinyi#; Tong, Linjing; Yang, Huangsheng;Wu,Jiayi; Zhang, Xiliu; Song,Ting*; Huang, Siming*; Zhu, Fang; Chen, Guosheng*;Ouyang, Gangfeng. A Biocatalytic Cascade in an Ultrastable Mesoporous HydrogenBonded Organic Framework for Point-of-Care Biosensing. Angew. Chem.Int. Ed.2021, 60, 23608-23613(Hot paper).

(14) Chen, Guosheng#; Huang, Siming#; Kou, Xiaoxue; Zhu, Fang;Ouyang, Gangfeng*. Embedding Functional Biomacromolecules withinPeptide-Directed Metal-Organic Framework (MOF) Nanoarchitectures EnablesActivity Enhancement. Angew. Chem.Int. Ed. 2020, 59, 13947-13954 (VIPpaper).

(15) Chen, Guosheng; Kou, Xiaoxue; Huang, Siming; Tong, Linjing;Shen, Yujian;Zhu, Wangshu; Zhu, Fang; Ouyang, Gangfeng*. Modulating theBiofunctionality of Metal-Organic Framework-Encapsulated Enzymes through ControllableEmbedding Patterns. Angew. Chem. Int. Ed. 2020, 59, 2867-2874 (ESI highlycited paper).

(16) Huang, Siming; Kou, Xiaoxue; Shen, Jun; Chen, Guosheng*Angew. Chem. Int. Ed. 2020, 59,8786-8798 (ESI highlycited paper).

(17) Chen, Guosheng; Huang, Siming; Kou, Xiaoxue; Wei, Songbo;Huang, Shuyao; Jiang, Shuqi; Shen, Jun; Zhu, Fang; Ouyang, Gangfeng*. AConvenient and Versatile Amino-Acid-Boosted Biomimetic Strategy for theNondestructive Encapsulation of Biomacromolecules within Metal–OrganicFrameworks. Angew. Chem.Int. Ed. 2019, 58, 1463 –1467(ESI highly citedpaper).

(18) Huang, Anlian; Yang, Huangsheng; Huang, Siming; Chen, Guosheng*;Ouyang, Gangfeng*. Hydrogen-bonded supramolecular crystal: A manual exoskeletonforbioentity. Matter 2023, 6, 2635–2646.

(19) Kou, Xiaoxue; Lin, Yuhong; Shen, Yong; Tong, Linjing; Gao, Rui; Liu,Suya; Huang, Siming; Zhu, Fang; Chen, Guosheng*; Gangfeng Ouyang.Biomimetic phosphohydrolase nanozyme based on defect-engineered metal-organicframework. CCS Chem. 2024, 6, 1821-1835.

(20) Huang, Wei#; Yuan, Haitao#; Yang, Huangsheng;Tong, Linjing; Gao, Rui; Kou, Xiaoxue; Wang, Jigang*; Ma, Xiaomin; Huang,Siming*; Zhu, Fang; Chen, Guosheng*; Ouyang, Gangfeng. PhotodynamicHydrogen-Bonded Biohybrid Framework: A Photobiocatalytic Cascade Nanoreactorfor Accelerating DiabeticWound Therapy. JACS Au 2022, 2, 2048-2058.

(21) Huang, Anlian; Tong, Linjing; Kou, Xiaoxue; Gao, Rui;Li, Zhi-Wei*;Huang, Siming*; Zhu, Fang; Chen, Guosheng*; Ouyang, Gangfeng. Structuraland Functional Insights intothe Biomineralized Zeolite Imidazole Frameworks. ACSNano 2023, 17, 24130−24140.

(22) Chen, Guosheng; Kou, Xiaoxue; Huang, Siming; Huang, Shuyao;Zhang, Rui; Liu, Chao; Shen, Jun; Zhu, Fang*; Ouyang, Gangfeng*.Allochroic-Graphene Oxide Linked 3D Oriented Surface Imprinting Strategy forGlycoproteins Assays. Adv. Funct. Mater. 2018,1804129.

(23) Chen, Guosheng; Fang, Xu’an; Chen, Qing; Zhang, Jin’ge; Zhong,Zhensong; Xu, Jianqiao; Zhu, Fang*; Ouyang, Gangfeng*. Boronic Acid Decorated DefectiveMetal–Organic Framework Nanoreactors for High-Efficiency Carbohydrates Separationand Labeling. Adv. Funct. Mater. 2017, 27, 1702126.

(24) Chen, Guosheng; Qiu, Junlang; Xu, Jianqiao; Fang, Xu’an; Liu,Yan; Liu,Shuqin; Wei, Songbo; Jiang, Ruifen; Zeng, Feng; Luan, Tiangang; Zhu,Fang*; Ouyang, Gangfeng*. A novel probe based on phenylboronic acidfunctionalized carbon nanotubes for ultrasensitive carbohydrate determinationin biofluids and semisolid biotissues. Chem. Sci. 2016, 7, 1487-1495.

(25) Ye, Niru; Huang, Siming; Yang, Huangsheng; Wu, Tong; Tong, Linjing;Zhu, Fang; Chen, Guosheng*; Ouyang, Gangfeng. Hydrogen-Bonded Biohybrid Framework-DerivedHighly Specific Nanozymes for Biomarker Sensing. Anal. Chem. 2021, 93,13981-13989.

(26) Zhong, Ningyi; Gao, Rui; Shen, Yujian; Kou, Xiaoxue; Wu, Jiayi;Huang, Siming*; Chen, Guosheng*; Ouyang, Gangfeng. Enzymes-EncapsulatedDefective Metal-Organic Framework Hydrogel Coupling with a Smartphone for aPortable Glucose Biosensor. Anal. Chem. 2022, 94, 14385–14393.

(27) Chen, Guosheng; Huang, Siming; Kou, Xiaoxue; Zhang, Jin’ge;Wang, Fuxin; Zhu, Fang*; Ouyang, Gangfeng*. Novel Magnetic Microprobe withBenzoboroxole-Modified Flexible Multisite Arm for High-Efficiency cis-DiolBiomolecule Detection. Anal. Chem.2018, 90, 3387-3394.

(28) Kou, Xiaoxue; Tong, Linjing; Shen, Yujian; Zhu, Wangshu; Yin, Li;Huang, Siming*; Zhu, Fang*; Chen, Guosheng*; Ouyang, Gangfeng.Smartphone-assisted robust enzymes@MOFs-based paper biosensor for point-of-caredetection. Biosensors and Bioelectronics 2020, 156, 112095.

(29) Wu, Tong; Huang, Siming*; Yang, Huangsheng; Ye, Niru; Tong, Linjing; Chen,Guosheng*; Zhou, Quan*; Ouyang, Gangfeng. Bimetal Biomimetic EngineeringUtilizing Metal–Organic Frameworks for Superoxide Dismutase Mimic. ACSMaterials Lett., 2022, 4, 4,751-757.

(30) Yang, Huangsheng; Fu, Jiahui; Huang, Wei; Huang, Wu,Tong; Huang,Siming; Chen, Guosheng*; Ouyang, Gangfeng. Self-Propelled,High-Crystalline Hydrogen-Bonded Enzymatic Framework Assembled by Bottom-UpStrategy. Small Structure 2023, 2200346.

(31) Gao. Rui; Zhong, Niyi; Tong, Linjing; Kou, Xiaoxue; Huang, Wei; Yang,Huangsheng; Huang Siming*; Wu, Jiayi; Chen, Guosheng*; Ouyang, Gangfeng.Mechanochemistry-guided reticular assembly for stabilizing enzymes withcovalent organic frameworks. Cell. Rep. Phys. Sci. 2022, 3, 101153.

(32) Gao, Rui; Ye, Niru; Kou, Xiaoxue; Shen, Yujian; Yang, Huangsheng; Wu,Tong; Huang, Siming*; Chen, Guosheng*; Ouyang, Gangfeng. Hierarchicallymesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity forphosphorylated biomarker sensing. Chem. Commun. 2022, 58, 12720-12723(HOT paper).

(33) Huang, Hao; Kou, Xiaoxue; Gao, Rui*; Huang, Siming; Chen,Guosheng*; Ouyang, Gangfeng. Enzyme-Immobilized Porous Crystals forEnvironmental Applications. Environ. Sci. Technol. 2024, 58, 27,11869–11886.

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