于晓强

山东大学教授

于晓强，男，1963年6月出生于吉林长春市。教授，博士生导师。1985年7月毕业于吉林大学化学系高分子专业，获学士学位。1988年毕业于清华大学化学工程系获工学硕士学位，1988年至1996年在山东工业大学任讲师。1996年入吉林大学化学学科攻读博士学位，1999年7月获博士学位后，入山东大学晶体材料国家重点实验室材料科学与工程博士后流动站进行博士后研究，2001年7月出站后留校工作。02年香港科技大学访问学者。吉林大学电子科学学院集成光电子国家重点实验室兼职教授。

研究领域

2000年开始从事双光子方面的工作，在双光子聚合方面已经取得了较大的成绩。目前的工作集中在双光子生物荧光探针的设计、制备和生物应用研究。此领域是一项多学科密集交叉的国际前沿领域，正在力争在该领域作出创造性的工作。经过十年的建设，实验室拥有先进有机材料制备、荧光性能表征、双光子性能测试、活性生物细胞与组织培育、生物荧光显微成像等一流设备。特别是双光子荧光测试系统、双光子生物荧光显微系统是我们根据生物荧光探针的实验要求自行建设的，并得到了国际国内同行的认可，我们的实验数据已经为浙江大学、中国科学院化学研究所、吉林大学、中国海洋大学、重庆大学等单位提供数据，并协助其发表论文。

科研课题

(1) 双光子光聚合反应的研究国家自然科学基金委员会

(2) 聚合物型三维光子晶体的激光微加工和微型光学器件研究国家自然科学基金委员会/香港资助局联合资助

(3) 生物学光学窗口的水溶性双光子荧光材料研究及相关核酸探针的探索国家自然科学基金委员会

(4) 光波段具有负折射特性的特殊周期介质结构的研究科技部973基础研究课题

(5)双光子DNA探针的研制济南试豪生物公司自主专利资助课题

论文发表

第一通讯作者论文：

AcceptedManuscript:

Xuechen Li,Minggang Tian, Ge Zhang, Ruoyao Zhang, Ruiqing, Feng, Lifang Guo，Xiaoqiang Yu*, Ning Zhao*, Xiuquan He*. Aspatial-dependent fluorescent probe for detecting different situations ofmitochondrial membrane potential conveniently and efficiently. Anal. Chem. 2017.2.14,DOI: 10.1021/acs.analchem.6b03842.

1. Minggang Tian,Yong Liu, Yuming Sun, Ruoyao Zhang, Ruiqing Feng, Ge Zhang, Lifang Guo, XuechenLi,Xiaoqiang Yu*, Jing Zhi Sun*,Xiuquan He*. A single fluorescent probe enables clearly discriminating andsimultaneously imaging liquid-ordered and liquid-disordered microdomains inplasma membrane of living cells. Biomaterilas 2017, 12, 46~56.

2. Minggang Tian,Yuming Sun, Lifang Guo, Ruoyao Zhang, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Ge Li，Xiaoqiang Yu*,XiuQuan He*. A small-structure two-photon platform equipped with weakelectrondonor: Development of permeable two-photon probes for lysosomesandmitochondria in living cells. Sensors and Actuators B 2017, 243, 955~962.

3. Lifang Guo,Ruoyao Zhang, Yuming Sun, Minggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Li He,Xiaoqiang Yu*,Xiuquan He*. Styrylpyridine salts-based red emissive two-photon turn-on probefor imaging the plasma membrane in living cells and tissues. Analyst 2016,141(11), 3228~3232.

4. Ge Zhang,Yuming Sun, Xiuquan He, Weijia Zhang, Minggang Tian, Ruiqing Feng, RuoyaoZhang, Xuechen Li, Lifang Guo,XiaoqiangYu*, Shangli Zhang*. Red-Emitting Mitochondrial Probe with UltrahighSignal-to-Noise Ratio Enables High-Fidelity Fluorescent Images in Two-PhotonMicroscopy. Analytical Chemistry 2015, 87(24), 12088~12095.

5. Ruiqing Feng,Yuming Sun, Minggang Tian, Ge Zhang, Ruoyao Zhang, Lifang Guo, Xuechen Li,Xiaoqiang Yu*, Ning Zhao*. Amembrane-permeable dye for living cells with large two-photon excitedfluorescence action cross-sections for bioimaging. Journal of MaterialsChemistry B 2015, 3(44), 8644~8649.

6. Guofen Song,Yuming Sun, Yong Liu, Xiankun Wang, Meiling Chen, Fang Miao, Weijia Zhang,Xiaoqiang Yu*, Jianling Jin*. Lowmolecular weight fluorescent probes with good photostability for imagingRNA-rich nucleolus and RNA in cytoplasm in living cells. Biomaterials 2014,35(7), 2103~2112.

7. Fang Miao,Weijia Zhang, Yuming Sun, Ruoyao Zhang, Yong Liu, Fuqiang Guo, Guofen Song,Minggang Tian,Xiaoqiang Yu*. Novelfluorescent probes for highly selective two-photon imaging of mitochondria inliving cells. Biosens. Bioelectron. 2014, 55(15), 423~429.

8. Minggang Tian,Fuqiang Guo, Yuming Sun, Weijia Zhang, Fang Miao, Yong Liu, Guofen Song, Cheuk-LamHo,Xiaoqiang Yu,* Jing Zhi Sun* andWai-Yeung Wong*. A fluorescent probe for intracellular cysteine overcoming theinterference by glutathione. Org. Biomol. Chem., 2014, 12(32), 6128~6133.

9. Yong Liu,Weijia Zhang, Yuming Sun, Guofen Song, Fang Miao, Fuqiang Guo, Minggang Tian,Xiaoqiang Yu*, Jing Zhi Sun*.Two-photon fluorescence imaging of RNA in nucleoli and cytoplasm in livingcells based on low molecular weight probes. Dyes and Pigments, 2014, 103(6), 191~201.

10. Junjie Wang,Yuming Sun, Weijia Zhang, Yong Liu,XiaoqiangYu*, Ning Zhao* A two-photon ratiometric fluorescent probe enables spatialcoordinates determination of intracellular pH. Talanta, 2014, 129, 241~248.

11. Fang Miao,Guofen Song, Yuming Sun, Yong Liu, Fuqiang Guo, Weijia Zhang, Minggang Tian,Xiaoqiang Yu*. Fluorescent imaging ofacidic compartments in living cells with a high selective novel one-photonratiometric and two-photon acidic pH probe. Biosens. Bioelectron. 2013, 50(4) 42~49.

12. Fuqiang Guo,Minggang Tian, Fang Miao, Weijia Zhang, Guofen Song, Yong Liu,Xiaoqiang Yu*, Jing Zhi Sun*, Wai-YeungWong*. Lighting up cysteine and homocysteine in sequence based on the kineticdifference of the cyclization/addition reaction. Org. Biomol. Chem., 2013,11(44), 7721~7728.

13. Zhiguang Yang,Ning Zhao, Yuming Sun, Fang Miao,Yong Liu, Xin Liu, Yuanhong Zhang, Wentao Ai,Guofen Song, Xiaoyuan Shen,Xiaoqiang Yu*,Jingzhi Sun* and Wai-Yeung Wong*. Highly selective red- and green-emittingtwo-photon fluorescent probes for cysteine detection and their bio-imaging inliving cells. Chem. Commun. 2012, 48(28), 3442~3444.

14. Guofen Song,Fang Miao, Yuming Sun,Xiaoqiang Yu*,Jing Zhi Sun*, Wai-Yeung Wong*, Fluorescence turn-on probes for intracellularRNA distribution and their imaging in confocal and two-photon fluorescencemicroscopy Sensor. Actuat. B-Chem. 2012, 173, 329~337.

15. Xin Liu,Yuming Sun, Yuanhong Zhang, Fang Miao, Guancong Wang, HongshiZhao,Xiaoqiang Yu*, Hong Liu* and Wai-YeungWong*. A 2,7-carbazole-baseddicationic salt for fluorescence detection ofnucleic acids and two-photon fluorescence imaging of RNA in nucleoli andcytoplasm Org. Biomol. Chem. 2011, 9(10), 3615-3618.

16. Xin Liu,Yuming Sun, Yuanhong Zhang, Ning Zhao, Guancong Wang, HongshiZhao,Xiaoqiang Yu,* Hong Liu* A Series ofCarbazole Cationic Compounds with Large Two-Photon Absorption Cross Sectionsfor Imaging Mitochondria in Living Cells with Two-Photon FluorescenceMicroscopy. J. Fluoresc. 2011, 21(2), 497-506.

17. Zhang Y. H.,Wang J. J., Jia P. F.,Yu X. Q.*,Liu H., Liu X., ZhaoN., Huang B. B. Two-photon fluorescence imaging of DNA inliving plant turbid tissue with carbazole dicationic salt. Org. Biomol. Chem.,2010, 8(20), 4582-4588.

18. ZHAO Ning,ZHANG YuanHong, LIU Xin,YU XiaoQiang*,GE MaoFa. Carbazoletricationic salt: a novel potential two-photon fluorescentDNA probe for nucleic imaging of cells Chin. Sci. Bull. 2010, 55(32),3661-3667.

19. ZHANGYuan-Hong, SUN Yu-Ming, LIU Xin, ZHAO Ning,YU Xiao-Qiang*, HUANG Bai-Biao*. Interaction Between DicationicCarbazole Derivatives and Nucleic Acidby Spectrum. CHEMICALJOURNAL OF CHINESEUNIVERSITIES 2010, 31(9), 1860-1863.

授权专利

1.于晓强、孙渝明一种单、双光子半胱氨酸荧光探针及其应用 ZL 2010 1 0558433.0

2.于晓强、冯瑞卿，孙渝明、苗芳一种单、双光子酸性细胞器荧光探针及其应用ZL201310018340.2

3.于晓强、田明刚、孙渝明、苗芳一种单、双光子线粒体荧光探针及其应用ZL 201310256318.1

4.于晓强、张革、孙渝明、宋国芬一种用于活细胞中RNA和核仁成像的吲哚吡啶盐类荧光探针，ZL 201310216501.9

5.于晓强、张若瑶、孙渝明、张革、宋国芬一种用于活细胞中RNA和核仁成像的吡咯吡啶盐类荧光探针，ZL 201310215970.9

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