官智

1997 - 2000 博士研究生，中山大学化学化工学院有机化学系

1994 - 1997 硕士研究生，中山大学化学化工学院有机化学系

1984 - 1988 本科，云南大学化学系

1991 - 1992 西安外国语学院出国人员外语强化部

生物有机化学、天然有机化学。

有机化合物的生物转化/生物催化、有机氟化物的合成方法研究、基于酶活性的小分子抑制剂的设计、合成、调控及应用研究。

重庆市自然科学基金重点项目：蛋白质与有机小分子相互作用的应用研究—基于功能的蛋白酪氨酸磷酸酶（PTPs）的富集分离研究，2010.01-2012.12

人事部留学人员科技活动择优资助项目：磷酸酶有机抑制剂的设计、合成及应用研究，2009.08-2010.07

教育部留学回国人员科研启动基金：蛋白磷酸酶PTPs含氟有机小分子抑制剂的设计、合成和应用研究，2006.09-2008.08

重庆市自然科学基金一般项目：磷酸蛋白酶PTPs活性探针库的合成研究， 2006.08-2008.07

西南大学校博士基金：磷酸酯酶的有机小分子抑制剂的合成研究，2006.01-2007.12

西南大学校高薪培育基金，与何延红共同主持：青霉菌分生孢子诱导剂的合成研究，2006.12-2008.11

1. Bennett, Matthew; Guan, Zhi; Laurberg, Martin; Su, Xiaodong.Bacillus subtilis Arsenate Reductase is Structurally and Functionally Similar to　Low-molecular-weight Protein Tyrosine Phosphatases (PTPs)，Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2001, 98(24), 13577-13582. IF2001= 10.231，（共同第一作者）2. Yang Yang; Yan-Hong He; Zhi Guan*; Wei-Da Huang. A Highly Efficient Large-scale Asymmetric Direct Intermolecular Aldol Reaction Employing L-Prolinamide as a Recoverable Catalyst. Advanced Synthesis & Catalysis. 2010, 352, 2579-2587. IF2009= 5.1873. Hai-Hong Li; Yan-Hong He; Yi Yuan; Zhi Guan*. Nuclease p1: A New Biocatalyst for Direct Asymmetric Aldol Reaction under Solvent-free Conditions. Green Chemistry. 2011, 13 (1), 185-189. IF2009= 5.8364. Hai-Hong Li; Yan-Hong He; Zhi Guan*. Protease-catalyzed Direct Aldol Reaction. Catalysis Communications. 2011, 12, 580-582. IF2009= 3.0005. Ying Hu; Yan-Hong He; Zhi Guan*. A Simple Method for the Preparation of Functionalized Trisubstituted Alkenes and a,b,g,d-Unsaturated Carbonyl Compounds by Using Natural Amino Acid L-Tryptophan. Catalysis Communications. 2010, 11(7), 656-659. IF2009= 3.0006. Guan, Zhi; Hederstedt, Lars; Li, Jinping; Su, Xiaodong.Preparation and Crystallization of a Bacillus subtilis Arsenate Reductase, Acta Cryst. D57, (UK), 2001, 1718-1721. IF2001= 3.5657. Di Wu, Yanhong He, Rongchang Tang, Zhi GuanThe First Synthesis of Diethyl a,a-ChlorofluorobenzylphosphonatesSYNLETT, 2009, (13), 2180-2182. IF2009= 2.7188. Rong-Chang Tang, Zhi Guan, Yan-Hong He and Wen ZhuEnzyme-Catalyzed Henry (Nitroaldol) ReactionJournal of Molecular Catalysis B: Enzymatic, 2010, 63, 62-67. IF2009= 2.0159. Jian-Feng Cai; Zhi Guan; Yan-Hong He*. The Lipase-catalyzed Asymmetric C-C Michael Addition. Journal of Molecular Catalysis B: Enzymatic. 2011, 68, (3-4), 240-244. IF2009= 2.01510. Shuai Zhao; Yan-Hong He; Di Wu; Zhi Guan*. A new general approach to 4-substituted -3-halo-2-quinolones. Journal of Fluorine Chemistry, 2010, 131, 597-605.11. Gang-Qiang Wang, Zhi Guan, Rong-Chang Tang, Zeljko Ostojic, T. Nicholas Jones, Ting-Ting Wu and Yan-Hong He.A Simple Preparation of Ethyl 2,5-Dimethylfuran-3-Carboxylate and 2,5-Dimethylfuran-3,4-Dicarboxylic Acid from Diethyl 2,3-Diacetylsuccinate.Journal of Heterocyclic Chemistry, 2009, 46(3), 540-54312. Ying Hu; Zhi Guan; Yan-Hong He*; Nathan Louwagie; and Meng-Jie Yao. L-Arginine Used as a Cost-effective and Recyclable Catalyst in Ionic Liquid for Synthesis of a,b-Unsaturated Nitriles and Ketones. Journal of Chemical Research 2010, (1) 22-24.13. Yan-hong He; Gang-Qiang Wang; Zhi Guan*. N-Substituted Pyrrole Synthesis by Paal-Knorr Condensation Using Recyclable Cationic Exchange Resin in Water. Journal of Heterocyclic Chemistry, 2010, 47, 486-489.14. Zhi Guan; Di Wu; Jian-Ping Fu; Yan-Hong He*. A Facile and Efficient Synthesis of Diethyl α,α-Chlorofluoroalkanephosphonates. Heteroatom Chemistry, 2010, 21 (4), 250-255.15. Yan-Hong He; Gang-Qiang Wang; Ke-Ling Xu; Zhi Guan*. An Efficient Procedure for the Synthesis of Polysubstituted Pyrroles in an Ionic Liquid. Z. Naturforsch. 2011, 66b, 191-196 (Zeitschrift fuer Naturforschung B - Chemical Sciences)16. Gangqiang Wang; Zhi Guan; Rongchang Tang; Yanhong He*. Ionic Liquid as Catalyst and Reaction Medium: a Simple and Efficient Procedure for Paal-Knorr Furan Synthesis, Synthetic Communications. 2010, 40(3): 370-377.17. Yan-Hong He, Gang-Qiang Wang, Ke-Ling Xu, Zhi Guan*. An Efficient Procedure for the Synthesis of Polysubstituted Pyrroles in an Ionic Liquid. Z. Naturforsch. 2011, 66b, 191-196 (Zeitschrift fuer Naturforschung B - Chemical Sciences)18. Zhi Guan, Longmei Zeng. A NEW CERAMIDE FROM A NEW SPECIES OF Spongia SPONGE. Chemistry of Natural Compounds (Title in Russian “Khimiya Prirodnykh Soedinenii”), 2010, 46(2), 287-288.19. Yan-Hong He, Ying Hu, Zhi Guan*. Natural α-Amino Acid L-Lysine Catalyzed Knoevenagel Condensations of α,β-Unsaturated Aldehydes and 1,3-Dicarbonyl Compounds. Synthetic Communications (accepted)20. Guang-Rong Cai, Zhi Guan, Yan-Hong He*. Synthesis of six-membered functionalized carbocyclic compounds by one-pot reaction of hydroquinone derivatives and dienes. Synthetic Communications (accepted)申请专利1 官智 吴狄 何延红。α, α-氟氯芳甲基膦酸酯及其制备方法。2009，中国专利申请号： 200910103270.42 官智 何延红 胡颖。L-色氨酸作为Knoevenagel反应催化剂的应用。2009，中国专利申请号：200910104709.63 官智 何延红 赵帅。4-取代-3-氟-2-喹诺酮的合成方法。2010，中国专利申请号： 201010042090.24 官智 何延红 赵帅。4-取代-3-氯-2-喹诺酮的合成方法。2010，中国专利申请号： 201010042091.75 官智 何延红 赵帅。4-取代-3-溴-2-喹诺酮的合成方法。2010，中国专利申请号：201010042092.16 官智 何延红 杨阳。L-脯氨酰胺衍生物及其制备方法和应用。2010，中国专利申请号： 201010203547.37 官智 何延红 吴狄。氟代双苯磺酰亚胺作为氮杂Diels-Alder反应催化剂的应用。2010，中国专利申请号： 201010129107.88 官智 何延红 蔡建峰。固定化脂肪酶Lipozyme TLIM作为不对称Michael加成反应催化剂的应用。2010，中国专利申请号： 201010201185.49 官智 何延红 胡颖。L-精氨酸在以离子液体为介质的Knoevenagel反应中作为催化剂的应用。2009，中国专利申请号： 200910191236.710 官智 何延红 胡颖。α,β,γ,δ-不饱和羰基化合物的合成方法。2009，中国专利申请号： 200910191235.2