童光志

中国农业科学院上海兽医研究所猪病毒性繁殖障碍综合症团队首席研究员，原所长

童光志，1962年10月8日生，男，湖北蕲春人，无党派，研究员，博士生导师。

人物经历

1982年毕业于华中农学院兽医系, 获农学学士学位，

1985年毕业于中国农业科学院研究生院,获农学硕士学位，

1990年毕业于中国人民解放军兽医大学，获农学博士学位。

1982-1986在中国农业科学院哈尔滨兽医研究所从事马传染性贫血病病毒的分子生物学研究

1986-1988在美国华盛顿州立大学从事牛I型和IV型疱疹病毒的分子克隆,物理图谱及重复序列研究

1989-1993在哈尔滨兽医研究所兽医生物技术国家重点实验室从事牛疱疹病毒及马传染性贫血病毒等的分子生物学研究

1993-1996.1在美国华盛顿州立大学美国农业部动物疾病研究中心作为访问教授从事牛恶性卡他热病毒(牛III型疱疹病毒)变异的分子基础研究

1996.1-2007在哈尔滨兽医研究所兽医生物技术国家重点实验室从事马传贫强弱毒比较及弱毒减毒分子基础；鸡、牛和猪疱疹病毒基因工程疫苗及其强弱毒分子鉴别诊断方法的研究；猪生殖-呼吸综合征病毒致病及免疫机理的研究。

2007.10任中国农业科学院上海兽医研究所所长，从事猪繁殖与呼吸综合征的治病与免疫机制，以及猪流感病毒分子流行病学以及猪在流感病毒跨种间的感染过程的作用，以及伪狂犬病毒及鸡痘病毒载体多价工程疫苗的研究、以及哺乳动物疫苗的研究。

社会任职

曾任兽医生物技术国家重点实验室主任，博士生导师；华中农业大学中国农业大学、华南农业大学和扬州大学等8所大学客座教授，黑龙江省政协委员，中国畜牧兽医学会兽医生物技术分会理事长。国务院政府特殊津贴获得者，首批入选“百千万人才工程”和农业部“神农计划”提名人，中国农业科学院跨世纪学科带头人，农业部有突出贡献中青年专家。863计划生物与现代农业领域基因操作主题专家组成员。

现任中国畜牧兽医学会动物传染病学分会、禽病学分会、畜牧兽医生物技术分会副理事长，中国微生物学会兽医微生物分会副主任委员，兽医生物技术国家重点实验室、家畜疫病病原生物学国家重点实验室和农业微生物国家重点实验室学术委员会委员，国家农业转基因生物安全委员会委员。

研究方向

多年来一直从事动物传染病病原流行病学及新型基因工程疫苗的研究，目前主要研究方向为猪繁殖障碍相关疫病（猪蓝耳病、猪流感、猪伪狂犬病、猪乙型脑炎等）的预防（动物用基因工程疫苗）与控制技术的应用与基础研究。

承担项目

1、国家重点研发计划

2、中国农业科学院创新工程

3、国家生猪现代产业技术体系科研专项

主要成就

研究成果获国家科技进步二等奖2项，省部级自然科学奖、技术发明奖、科技进步奖14项；两项疫苗产品获得新兽药证书，8种基因工程疫苗获得转基因安全证书，获得国家发明专利23项；在国内外专业期刊上发表学术论文600余篇，其中在国际杂志发表190余篇，主编/参编著作11部；培养博士后16名、博士研究生63名、硕士研究生86名。

所获荣誉

国务院政府津贴获得者，国家“百千万人才”入选人，六部委共同颁发的留学人员成就奖，全国优秀科技工作者，全国优秀博士学位论文指导教师，首届全国优秀农业科技工作者，农业部有突出贡献中青年专家，第九届黑龙江省劳动模范，第十二届上海市科技精英，哈尔滨市劳动模范，第四届中华农业英才奖。

上海领军人才（2008）、上海市十大科技精英（2011）。

代表论著

（1）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*. Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.

（2）Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

（3）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*. Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.

（4）Kuan Zhao§, Li-Wei Li§, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.

（5）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein B contribute to immunogenic difference between PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.

（6）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53:4-14.

（7）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong , Fei Gao, Zhiyong Ma, Guangzhi Tong*. Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.

（8）Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.

（9）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang, Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*. Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.

（10）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.

（11）Yi-feng Jiang#，Tian-qi Xia#，Yan-jun Zhou，Ling-xue Yu， Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.

（12）Chao Ye†, Qing-Zhan Zhang†, Zhi-Jun Tian†, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang, Mang Shi, Xiao-Bo Chang, Yi-Feng Jiang, Jin-Mei Peng, Yan-Jun Zhou, Yan-Dong Tang, Ming-Xia Sun, Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidence for existence of two major genotypes. Virology, 2015, 483:32-43.

（13）Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.

（14）Tong-Qing An1, Jin-Mei Peng1, Zhi-Jun Tian1, Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen, Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749- 1755.

（15）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication in vivo. Journal of Virology, 2012, 86（18）：9941-9951.

（16）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*. Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.

（17）Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

（18）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*. Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.

（19）Kuan Zhao§, Li-Wei Li§, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.

（20）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein B contribute to immunogenic difference between PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.

（21）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53:4-14.

（22）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong , Fei Gao, Zhiyong Ma, Guangzhi Tong*. Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.

（23）Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.

（24）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang, Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*. Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.

（25）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.

（26）Yi-feng Jiang#，Tian-qi Xia#，Yan-jun Zhou，Ling-xue Yu， Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.

（27）Chao Ye†, Qing-Zhan Zhang†, Zhi-Jun Tian†, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang, Mang Shi, Xiao-Bo Chang, Yi-Feng Jiang, Jin-Mei Peng, Yan-Jun Zhou, Yan-Dong Tang, Ming-Xia Sun, Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidence for existence of two major genotypes. Virology, 2015, 483:32-43.

（28）Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.

（29）Tong-Qing An1, Jin-Mei Peng1, Zhi-Jun Tian1, Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen, Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749- 1755.

（30）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication in vivo. Journal of Virology, 2012, 86（18）：9941-9951.

获奖

国家奖

省部级奖

获得部级科技成果奖4项。

1、《肉食兽细小病毒通用核酸探针的制备及应用研究》获1992年总后勤部科技进步二等奖。

2、《犬腺病毒通用和特异DNA探针的制备及应用研究》获1992年总后勤部科技进步三等奖。

3、《鸡传染性喉气管炎病毒三个基因的克隆鉴定及研究》获1997年哈尔滨市科委科技进步二等奖。

4、《猪呼吸及生殖障碍综合征病原的分离鉴定》获1997年农业部科技进步三等奖。

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