翁江

中山大学药学院副教授

翁江，男，1982年11月生，博士，中山大学药学院副教授、硕士生导师。主要研究领域为药物合成化学和有机合成化学。先后承担国家自然科学基金、广东省自然科学基金重等多项基金项目，在国内外重要学术期刊上发表SCI论文40余篇，申请和获得授权发明专利4项。

研究方向

不对称催化和手性技术

手性药物的高效合成

活性天然产物的全合成

人物经历

2012/7-至今，中山大学药学院，历任讲师和副教授

2017/12-2018/12，美国Scripps研究所，访问学者

2010/07 – 2012/07，中山大学药学院，博士后

2007/09 – 2010/06，中山大学药学院，有机化学专业，博士

2005/09 – 2007/06，中山大学化工学院，有机化学专业，硕士

2001/09 – 2005/06，湖北大学化材学院，应用化学专业，学士

教授课程

有机化学；有机化学实验

科研项目

近年主持的纵向科研项目：

1. 国家自然科学基金-青年科学基金项目：环戊烯酮类前列腺素的合成新方法及其靶向白血病干细胞活性研究；21502240；2016.1-2018.12；

2. 广东省自然科学基金项目-自由申请项目：基于有机催化串联反应构建环状DPP-4抑制剂及其降血糖活性研究；2015A030313130；2015.8.1-2018.8.1；

3. 广东省自然科学基金项目-博士启动项目：有机催化串联Michael/Wittig/Aldol反应及其在前列腺素合成中的应用；S2013040012409；2013.10-2015.10；

4. 广东省医学科学基金项目：前列腺素F的高效合成新方法研究；A2015167；2015.7-2017.6；

5. 中央高校基本科研业务费-中山大学青年教师培育计划项目：2012.11-2015.11；

6. 中山大学青年教师起步资助计划；2012.12-2013.12

发表论文

1.Jun-Ming Li,Yong-Heng Wang,Yang Yu,Ruibo Wu,Jiang Weng,*Gui Lu.*Copper-catalyzed remote C–H functionalizations of naphthylamides through coordinating activation strategy and single-electron-transfer (SET) mechanism.ACS Catalysis,2017,7, 2661-2667.

Chem. Commun.2015,51, 10170-10173.(HighlightedbyOrganicChemistryPortal)

3.Lin-Jie Huang,Jiang Weng,*Sheng Wang, Gui Lu.*Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles.Adv. Synth. Catal.2015,357(5), 993-1003.(HighlightedbyX-MOL)

4.Jiang Weng, Jun-Ming Li, Feng-Quan Li, Zhi-Sheng Xie, Gui Lu.*Asymmetric domino nitro-Michael/Horner-Wadsworth-Emmons reaction for disubstituted cyclohexenecarboxylate annulation: efficient synthesis of DPP-4 inhibitor ABT-341 and influenza neuraminidase inhibitors.Adv. Synth. Catal.,2012,354, 1961-1970.

5.Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Gui Lu.Organocatalytic Michael reaction of nitroenamines with aldehydes: efficient asymmetric synthesis of (−)-oseltamivir.ChemCatChem,2012,4, 1007-1012. (Invited paper)

6.Jiang Weng,Yong-Bo Li, Rui-Bin Wang, Feng-Quan Li, Can Liu, Albert S. C. Chan, Gui Lu.A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate.J. Org. Chem.,2010,75, 3125-3128. (Highlighted bySYNFACTS, 2010,8, 857)

7.Wei-Jie Huang, Qing Chen, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong,Jiang Weng*, Gui Lu* Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions.Org. Chem. Front.,2017,4, 472-482.

8.Can Liu,Jiang Weng*, Zi-Hui Lin, Wei-Jie Huang, Jing Guo, Lin-Jie Huang, Gui Lu*, Asymmetric synthesis of vicinal amino alcohols via organocatalytic sequential α-amination/Grignard addition reactions of aldehydes.Tetrahedron: Asymmetry,2017,28, 41-46.

9.Jiang Weng, Lin-Jie Huang, Liang Long, Ling-Yi Xu, Gui Lu.Enantioselective synthesis ofsyn-2-amino-1,3-diols via organocatalytic sequential oxa-Michael/α-amination reactions of α,β-unsaturated aldehydes.Tetrahedron Lett.,2016, 57, 2554-2557.

10.Jun-Ming Li,Jiang Weng,* Gui Lu, Albert S.C. Chan. Copper-catalyzed C5-regioselective C-H sulfonylation of 8-aminoquinoline amides with aryl sulfonyl chlorides.Tetrahedron Lett.,2016,57, 2121-2124.

11.Jing Guo,JiangWeng,* Gong-BinHuang,Lin-JieHuang, Albert S. C.Chan,Gui Lu.*Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3'-biindoles.Tetrahedron Lett.,2016,57,5493-5496.

12.Yi Chen, Hui Yan, Hui-Xuan Chen,Jiang Weng,* Gui. Lu.* An Improved and Efficient Process for the Preparation of (+)-Cloprostenol.Chirality2015,27, 392-396.

13.Jiang Weng, Hui-Bing Ai, Ren-Shi Luo, Gui Lu, Asymmetric Michael reaction of aldehydes with β-nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors.Chirality2012,24, 271-275.

14.Hui-Xuan Chen, Lin-Jie Huang, Jin-Biao Liu,Jiang Weng,* Gui Lu.* Synthesis of Terminal Vinylphosphonates Via DBU-Promoted Tandem Phospha-Michael/Elimination Reactions.PHOSPHORUS SULFUR.2014,189, 1858-1866.

15.Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Yang Yu, Zheng-Chao Tu, Zi-Jie Long, Xiao-Ju Lai, Hui-Xuan Chen, Yu Luo,Jiang Weng, Gui Lu. Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.J. Med. Chem.2016, 59, 7268–7274.

16. Jin-Biao Liu, Hui Yan, Hui-Xuan Chen, Yu Luo,Jiang Weng, Gui Lu. Palladium-catalyzed Suzuki cross-coupling of N'-tosyl arylhydrazines.Chem. Commun.2013,49, 5268-5270.

17 Ren-Shi Luo,Jiang Weng, Hui-Bing Ai, Gui Lu, Albert S. C. Chan, Highly efficient asymmetric Michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts.Adv. Synth. Catal.,2010,351, 2449-2459.

18.Yong-Jie Luo, Hui-Xuan Chen,Jiang Weng, Gui Lu. Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase.Mar. Drugs2016, 14, 118.

19. Ji-Quan, Zhang, Gong-Bin Huang,Jiang Weng, Gui Lu, Albert S. C. Chan. Copper(II)-catalyzed coupling reaction: an efficient and regioselective approach to N',N'-diaryl acylhydrazines.Org. Biomol.Chem.2015,13, 2055-2063.

20. Jin-Biao Liu, Lin Nie, Hui Yan, Li-Hua Jiang,Jiang Weng,Gui Lu. Palladium-catalyzed reductive homocoupling of N'-tosyl aryl hydrazines.Org. Biomol.Chem.2013,11, 8014-8017.

21.Ya-Hui Feng, Ren-Shi Luo, Lin Nie,Jiang Weng, Gui Lu. Chiral diphenylperhydroindolinol silyl ether catalyzed domino oxa-Michael-aldol condensations for the asymmetric synthesis of benzopyrans.Tetrahedron: Asymmetry2014,25, 523-528.

22. Gong Chen,Jiang Weng, Zhan-Chao Zheng, Xin-Hai Zhu, Yao-Yao Cai, Ji-Wen Cai, Yi-Qian Wan, Pd/C-catalyzed cyanation of aryl halides in aqueous PEG.Eur. J. Org. Chem.,2008, (20), 3524-3528.

23.Can Liu, Zong-Liang Guo,Jiang Weng, Gui Lu, Albert S. C. Chan, Chiral1,1'-binaphthylazepine-derived amino alcohol catalyzed asymmetric aryl transfer reactions with boroxine as aryl source.Chirality2010,22, 159-164.

24.Gong Chen, Jian-Wei Xie,Jiang Weng, Xin-Hai Zhu, Zhan-Chao Zheng, Ji-Wen Cai, Yi-Qian Wan, CuI/PPh3/PEG-water: An efficient catalytic system for cross-coupling reaction of aryl iodides and alkynes.Synthetic Commun.2011,41, 3123-3133.

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